| Title: | Medication use in uncontrolled pediatric asthma : results from the SysPharmPediA study |
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| Authors: | ID Alizadeh Bahmani, Amir Hossein (Author)
ID Slob, Elise M. A. (Author)
ID Bloemsma, Lizan D. (Author)
ID Brandstetter, Susanne (Author)
ID Corcuerea, Paula (Author)
ID Gorenjak, Mario (Author)
ID Harner, Susanne (Author)
ID Hashimoto, Simone (Author)
ID Hedman, Anna M. (Author)
ID Kabesch, Michael (Author)
ID Potočnik, Uroš (Author) |
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| Files: |  Medication_use_in_uncontrolled_pe-Bahmani-2022.pdf (639,57 KB)
MD5: 18DFB97A500929AFACD9A23A893A46BB
 https://www.sciencedirect.com/science/article/pii/S0928098722002457
https://doi.org/10.1016/j.ejps.2022.106360
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| Language: | English |
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| Work type: | Scientific work |
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| Typology: | 1.01 - Original Scientific Article |
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| Organization: | MF - Faculty of Medicine
FKKT - Faculty of Chemistry and Chemical Engineering
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| Abstract: | Background
Uncontrolled pediatric asthma has a large impact on patients and their caregivers. More insight into determinants of uncontrolled asthma is needed. We aim to compare treatment regimens, inhaler techniques, medication adherence and other characteristics of children with controlled and uncontrolled asthma in the: Systems Pharmacology approach to uncontrolled Paediatric Asthma (SysPharmPediA) study.
Material and methods
145 children with moderate to severe doctor-diagnosed asthma (91 uncontrolled and 54 controlled) aged 6–17 years were enrolled in this multicountry, (Germany, Slovenia, Spain, and the Netherlands) observational, case-control study. The definition of uncontrolled asthma was based on asthma symptoms and/or exacerbations in the past year. Patient-reported adherence and clinician-reported medication use were assessed, as well as lung function and inhalation technique. A logistic regression model was fitted to assess determinants of uncontrolled pediatric asthma.
Results
Children in higher asthma treatment steps had a higher risk of uncontrolled asthma (OR (95%CI): 3.30 (1.56–7.19)). The risk of uncontrolled asthma was associated with a larger change in FEV1% predicted post and pre-salbutamol (OR (95%CI): 1.08 (1.02–1.15)). Adherence and inhaler techniques were not associated with risk of uncontrolled asthma in this population.
Conclusion
This study showed that children with uncontrolled moderate-to-severe asthma were treated in higher treatment steps compared to their controlled peers, but still showed a higher reversibility response to salbutamol. Self-reported adherence and inhaler technique scores did not differ between controlled and uncontrolled asthmatic children. Other determinants, such as environmental factors and differences in biological profiles, may influence the risk of uncontrolled asthma in this moderate to severe asthmatic population. |
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| Keywords: | pediatric asthma, asthma control, uncontrolled asthma, medication, adherence, inhaler technique |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Publication date: | 01.02.2023 |
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| Year of publishing: | 2023 |
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| Number of pages: | str. 1-7 |
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| Numbering: | Vol. 181, article no.106360 |
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| PID: | 20.500.12556/DKUM-85022  |
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| UDC: | 616.2 |
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| ISSN on article: | 1879-0720 |
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| COBISS.SI-ID: | 134636035 |
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| DOI: | 10.1016/j.ejps.2022.106360 |
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| Publication date in DKUM: | 16.08.2023 |
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| Views: | 472 |
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| Downloads: | 44 |
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| Metadata: |    |
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| Categories: | Misc.
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