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Title:Skeletal muscle uncoupling proteins in mice models of obesity
Authors:ID Križančić Bombek, Lidija (Author)
ID Čater, Maša (Author)
Files:URL https://www.mdpi.com/2218-1989/12/3/259
.pdf Skeletal_Muscle_Uncoupling_Protein-Bombek-2022.pdf (1,36 MB)
MD5: 18E01A881531BF168F1CC6AE5EA4876B
Work type:Scientific work
Typology:1.02 - Review Article
Organization:MF - Faculty of Medicine
Abstract:Obesity and accompanying type 2 diabetes are among major and increasing worldwide problems that occur fundamentally due to excessive energy intake during its expenditure. Endotherms continuously consume a certain amount of energy to maintain core body temperature via thermogenic processes, mainly in brown adipose tissue and skeletal muscle. Skeletal muscle glucose utilization and heat production are significant and directly linked to body glucose homeostasis at rest, and especially during physical activity. However, this glucose balance is impaired in diabetic and obese states in humans and mice, and manifests as glucose resistance and altered muscle cell metabolism. Uncoupling proteins have a significant role in converting electrochemical energy into thermal energy without ATP generation. Different homologs of uncoupling proteins were identified, and their roles were linked to antioxidative activity and boosting glucose and lipid metabolism. From this perspective, uncoupling proteins were studied in correlation to the pathogenesis of diabetes and obesity and their possible treatments. Mice were extensively used as model organisms to study the physiology and pathophysiology of energy homeostasis. However, we should be aware of interstrain differences in mice models of obesity regarding thermogenesis and insulin resistance in skeletal muscles. Therefore, in this review, we gathered up-to-date knowledge on skeletal muscle uncoupling proteins and their effect on insulin sensitivity in mouse models of obesity and diabetes.
Keywords:uncoupling protein, skeletal muscle, insulin, diabetes, obesity
Publication status:Published
Publication version:Version of Record
Publication date:01.01.2022
Year of publishing:2022
Number of pages:str. 1-22
Numbering:no. 3, art. 259
PID:20.500.12556/DKUM-84947 New window
ISSN on article:2218-1989
COBISS.SI-ID:107486467 New window
DOI:10.3390/metabo12030259 New window
Publication date in DKUM:10.08.2023
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Record is a part of a journal

Shortened title:Metabolites
Publisher:MDPI AG
COBISS.SI-ID:523274009 New window

Document is financed by a project

Funder:ARRS - Slovenian Research Agency
Project number:J3-9289
Name:Vloga cikličnega adenozin monofosfata v normalni fiziologiji celic beta in med razvojem sladkorne bolezni tipa 2

Funder:ARRS - Slovenian Research Agency
Project number:N3-0133
Name:Celice beta med razvojem in remisijo z dieto povzročene sladkorne bolezni

Funder:ARRS - Slovenian Research Agency
Project number:P3-0396
Name:Celične in tkivne mreže


License:CC BY 4.0, Creative Commons Attribution 4.0 International
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.

Secondary language

Keywords:fiziologija človeka, patofiziologija, diabetes, debelost, beljakovine, skeletne mišice, laboratorijske miši


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