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Title:A system pharmacology multi-omics approach toward uncontrolled pediatric asthma
Authors:ID Abdel-Aziz, Mahmoud I. (Author)
ID Gorenjak, Mario (Author)
ID Potočnik, Uroš (Author)
Files:.pdf A_System_Pharmacology_Multi-Om-Abdel-Aziz-2021.pdf (1,29 MB)
MD5: 116B45F829BB40FF3424D991C89229BB
URL https://www.mdpi.com/2075-4426/11/6/484
Work type:Scientific work
Typology:1.01 - Original Scientific Article
Organization:MF - Faculty of Medicine
Abstract:There is a clinical need to identify children with poor asthma control as early as possible, to optimize treatment and/or to find therapeutic alternatives. Here, we present the “Systems Pharmacology Approach to Uncontrolled Pediatric Asthma” (SysPharmPediA) study, which aims to establish a pediatric cohort of moderate-to-severe uncontrolled and controlled patients with asthma, to investigate pathophysiological mechanisms underlying uncontrolled moderate-to-severe asthma in children on maintenance treatment, using a multi-omics systems medicine approach. In this multicenter observational case–control study, moderate-to-severe asthmatic children (age; 6–17 years) were included from four European countries (Netherlands, Germany, Spain, and Slovenia). Subjects were classified based on asthma control and number of exacerbations. Demographics, current and past patient/family history, and clinical characteristics were collected. In addition, systems-wide omics layers, including epi(genomics), transcriptomics, microbiome, proteomics, and metabolomics were evaluated from multiple samples. In all, 145 children were included in this cohort, 91 with uncontrolled (median age = 12 years, 43% females) and 54 with controlled asthma (median age = 11.7 years, 37% females). The two groups did not show statistically significant differences in age, sex, and body mass index z-score distribution. Comprehensive information and diverse noninvasive biosampling procedures for various omics analyses will provide the opportunity to delineate underlying pathophysiological mechanisms of moderate-to-severe uncontrolled pediatric asthma. This eventually might reveal novel biomarkers, which could potentially be used for noninvasive personalized diagnostics and/or treatment.
Keywords:pediatric asthma, uncontrolled asthma, omics, systems medicine
Publication status:Published
Publication version:Version of Record
Publication date:01.01.2021
Year of publishing:2021
Number of pages:str. 1-16
Numbering:Vol. 11, iss. 6
PID:20.500.12556/DKUM-84865 New window
ISSN on article:2075-4426
COBISS.SI-ID:65569795 New window
DOI:10.3390/jpm11060484 New window
Publication date in DKUM:02.08.2023
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Record is a part of a journal

Title:Journal of personalized medicine
Shortened title:J. pers. med.
COBISS.SI-ID:31207641 New window

Document is financed by a project

Funder:Drugi - Drug financer ali več financerjev
Funding programme:ZonMW
Project number:9003035001

Funder:Drugi - Drug financer ali več financerjev
Funding programme:Ministry of Education, Science, and Sport of the Republic of Slovenia
Project number:C330-16-500106

Funder:Drugi - Drug financer ali več financerjev
Funding programme:German Ministry of Education and Research
Project number:FKZ 031L0088

Funder:Drugi - Drug financer ali več financerjev
Funding programme:Instituto de Salud Carlos III
Project number:AC15/00015

Funder:Drugi - Drug financer ali več financerjev
Funding programme:Instituto de Salud Carlos III
Project number:AC15/00058

Funder:Drugi - Drug financer ali več financerjev
Funding programme:ERACoSysMed JTC-1 Call. M.P.-Y.
Project number:RYC-2015-17205

Funder:Drugi - Drug financer ali več financerjev
Funding programme:MICINN
Project number:FPU19/02175

Funder:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Project number:P3-0067
Name:Farmakologija in farmakogenomika

Funder:Drugi - Drug financer ali več financerjev
Funding programme:Swedish Research Council
Project number:2018-02640


License:CC BY 4.0, Creative Commons Attribution 4.0 International
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.

Secondary language

Keywords:otroška astma, nekontrolirana astma, medicina


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