| Naslov: | Genomic insights into antibiotic resistance and mobilome of lactic acid bacteria and bifidobacteria |
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| Avtorji: | ID Rozman, Vita (Avtor)
ID Mohar Lorbeg, Petra (Avtor)
ID Treven, Primož (Avtor)
ID Accetto, Tomaž (Avtor)
ID Janežič, Sandra (Avtor)
ID Rupnik, Maja (Avtor)
ID Bogovič Matijašić, Bojana (Avtor) |
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| Datoteke: |  Rozman-2023-Genomic_insights_into_antibiotic_r.pdf (4,16 MB)
MD5: F2781350D229BD7A856B10C25BA9E339
 http://doi.org/10.26508/lsa.202201637
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| Jezik: | Angleški jezik |
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| Vrsta gradiva: | Znanstveno delo |
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| Tipologija: | 1.01 - Izvirni znanstveni članek |
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| Organizacija: | MF - Medicinska fakulteta
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| Opis: | Lactic acid bacteria (LAB) and Bifidobacterium sp. (bifidobacteria) can carry antimicrobial resistance genes (ARGs), yet data on resistance mechanisms in these bacteria are limited. The aim of our study was to identify the underlying genetic mechanisms of phenotypic resistance in 103 LAB and bifidobacteria using whole-genome sequencing. Sequencing data not only confirmed the presence of 36 acquired ARGs in genomes of 18 strains, but also revealed wide dissemination of intrinsic ARGs. The presence of acquired ARGs on known and novel mobile genetic elements raises the possibility of their horizontal spread. In addition, our data suggest that mutations may be a common mechanism of resistance. Several novel candidate resistance mechanisms were uncovered, providing a basis for further in vitro studies. Overall, 1,314 minimum inhibitory concentrations matched with genotypes in 92.4% of the cases; however, prediction of phenotype based on genotypic data was only partially efficient, especially with respect to aminoglycosides and chloramphenicol. Our study sheds light on resistance mechanisms and their transferability potential in LAB and bifidobacteria, which will be useful for risk assessment analysis. |
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| Status publikacije: | Objavljeno |
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| Verzija publikacije: | Objavljena publikacija |
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| Poslano v recenzijo: | 28.07.2022 |
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| Datum sprejetja članka: | 30.01.2023 |
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| Datum objave: | 13.02.2023 |
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| Založnik: | Life Science Alliance, LLC |
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| Leto izida: | 2023 |
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| Št. strani: | Str. 1-15 |
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| Številčenje: | Letn. 6, Št. 4, št. članka 202201637 |
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| PID: | 20.500.12556/DKUM-84042  |
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| UDK: | 579:575 |
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| COBISS.SI-ID: | 141893123 |
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| DOI: | 10.26508/lsa.202201637 |
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| ISSN pri članku: | 2575-1077 |
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| Datum objave v DKUM: | 17.07.2024 |
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| Število ogledov: | 106 |
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| Število prenosov: | 3 |
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| Metapodatki: |     |
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| Področja: | Ostalo
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