| Title: | Brain dynamics underlying preserved cycling ability in patients with Parkinson’s disease and freezing of gait |
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| Authors: | ID Ličen, Teja (Author)
ID Rakuša, Martin (Author)
ID Bohnen, Nicolaas I. (Author)
ID Manganotti, Paolo (Author)
ID Marušič, Uroš (Author) |
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| Files: |  Licen_2022_Brain_Dynamics_Underlying_Preserved.pdf (473,54 KB)
MD5: 3AF952BC39541AE96E99B7BE18CA448F
 https://doi.org/10.3389/fpsyg.2022.847703
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| Language: | English |
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| Work type: | Scientific work |
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| Typology: | 1.02 - Review Article |
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| Organization: | MF - Faculty of Medicine
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| Abstract: | Parkinson’s disease (PD) is generally associated with abnormally increased beta band oscillations in the cortico-basal ganglia loop during walking. PD patients with freezing of gait (FOG) exhibit a more distinct, prolonged narrow band of beta oscillations that are locked to the initiation of movement at ∼18 Hz. Upon initiation of cycling movements, this oscillation has been reported to be weaker and rather brief in duration. Due to the suppression of the overall beta band power during cycling and its continuous nature of the movement, cycling is considered to be less demanding for cortical networks compared to walking, including reduced need for sensorimotor processing, and thus unimpaired continuous cycling motion. Furthermore, cycling has been considered one of the most efficient non-pharmacological therapies with an influence on the subthalamic nucleus (STN) beta rhythms implicative of the deep brain stimulation effects. In the current review, we provide an overview of the currently available studies and discuss the underlying mechanism of preserved cycling ability in relation to the FOG in PD patients. The mechanisms are presented in detail using a graphical scheme comparing cortical oscillations during walking and cycling in PD. |
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| Keywords: | gait, freezing of gait, Parkinson's disease, cycling, cortical oscillations, beta band |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Submitted for review: | 03.01.2022 |
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| Article acceptance date: | 20.05.2022 |
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| Publication date: | 16.06.2022 |
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| Publisher: | Frontiers Research Foundation |
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| Year of publishing: | 2022 |
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| Number of pages: | Str. 1-6 |
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| Numbering: | Letn. 13, št. članka 847703 |
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| PID: | 20.500.12556/DKUM-81962  |
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| UDC: | 616.858:796.01 |
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| ISSN on article: | 1664-1078 |
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| COBISS.SI-ID: | 112226563 |
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| DOI: | 10.3389/fpsyg.2022.847703 |
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| Publication date in DKUM: | 04.12.2024 |
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| Views: | 0 |
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| Downloads: | 4 |
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| Metadata: |    |
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| Categories: | Misc.
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