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Title:Vpliv presnovnega sindroma na razvoj anksioznemu in depresivnemu vedenju podobnega obnašanja pri mišjem modelu sladkorne bolezni tipa 2 : magistrsko delo
Authors:ID Polšak, Nika (Author)
ID Dolenšek, Jurij (Mentor) More about this mentor... New window
ID Skelin, Maša (Comentor)
Files:.pdf MAG_Polsak_Nika_2022.pdf (2,41 MB)
MD5: 9631A4897A723441348FA6ACE2EAACA7
PID: 20.500.12556/dkum/bee8cbf2-5f7b-47b8-a643-3489db97b19a
 
Language:Slovenian
Work type:Master's thesis/paper
Typology:2.09 - Master's Thesis
Organization:FNM - Faculty of Natural Sciences and Mathematics
Abstract:V današnjem času je presnovni sindrom vse bolj pogosta presnovna motnja. Presnovni sindrom je močno povezan s sladkorno boleznijo tipa 2 (SBT2) in duševnimi motnjami. Predvsem prevalenci anksioznosti in depresivnosti naraščata na globalni ravni. Namen raziskave je bil preučiti pojav anksioznemu in depresivnemu vedenju podobnega obnašanja na mišjem modelu SBT2. Pri tem nas je zanimal tudi vpliv spola. V ta namen smo miši razdelili v tri skupine. Prva skupina je predstavljala kontrolno skupino, ki smo jo hranili s standardno prehrano (CD). Drugo skupino smo hranili z zahodno dieto (WD). Tretjo skupino smo po obdobju hranjenja z WD izpostavili kratkotrajni kalorični restrikciji (RCD), saj nas je zanimalo, ali bo kalorična restrikcija, ki povzroči remisijo SBT2, povzročila tudi zmanjšanje nagnjenosti k anskioznemu in depresivnemu vedenju podobnemu obnašanju. Vpliv prehranskega režima smo ocenjevali s pomočjo vedenjskih testov. Za ocenjevanje lokomotorike smo uporabili test odprtega polja (OFT), za ocenjevanje anskioznemu vedenju podobnega obnašanja test dvignjenega labirinta v obliki križa (EPM) in za ocenjevanje depresivnemu vedenju podobnega obnašanja test prisilnega plavanja (FST). Ugotovili smo, da indukcija SBT2 z zahodno dieto ni vplivala na pojav anskioznemu in depresivnemu vedenju podobnega obnašanja pri miših. Prav tako na pojav omenjenih motenj ni vplival spol. Ugotovili pa smo, da so bile WD samice bolj aktivne kot WD samci (bile so hitrejše, prehodile so večjo razdaljo in manj časa mirovale). V skladu s tem, da indukcija SBT2 ni vplivala na teste anskioznemu in depresivnemu podobnemu obnašanju, tudi kalorična restrikcija ni vplivala na k anskioznemu in depresivnemu vedenju podobnemu obnašanju. Opazili smo vpliv habituacije na nekatere vedenjske teste. Pri testu OFT smo opazili zmanjšanje raziskovalnega vedenja pri ponavljanju testa, pri testu EPM pa zmanjšano raziskovanje odprtih krakov pri ponavljanju testa.
Keywords:presnovni sindrom, sladkorna bolezen, anksioznost, depresivnost, zahodna dieta, kalorična restrikcija, vedenjski testi
Place of publishing:Maribor
Place of performance:Maribor
Publisher:[N. Polšak]
Year of publishing:2022
Number of pages:XI f., 55 str.
PID:20.500.12556/DKUM-81382 New window
UDC:57.017.7:613.86:616.379-008.64(043.2)
COBISS.SI-ID:103367939 New window
Publication date in DKUM:06.04.2022
Views:924
Downloads:71
Metadata:XML DC-XML DC-RDF
Categories:FNM
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Licences

License:CC BY-NC-ND 4.0, Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
Link:http://creativecommons.org/licenses/by-nc-nd/4.0/
Description:The most restrictive Creative Commons license. This only allows people to download and share the work for no commercial gain and for no other purposes.
Licensing start date:11.03.2022

Secondary language

Language:English
Title:Influence of metabolic syndrome on the development of anxiety and depressive behaviors on mouse model of type 2 diabetes mellitus
Abstract:Nowadays, metabolic syndrome is an increasingly common metabolic disorder. Metabolic syndrome is strongly associated with type 2 diabetes (T2D) and mental disorders. In particular, the prevalence of anxiety and depression is growing globally. The aim of the study was to examine the occurrence of anxiety and depressive and depressive-like behaviors in the T2D mouse model. We were also interested in the influence of gender. For this purpose, we divided the mice into three groups. The first group represented a control group fed a classical diet (CD). The second group was fed a western diet (WD). The third group was exposed to a reduced-calorie diet (RCD) after a period of WD feeding, as we were interested in whether caloric restriction, which causes T2D remission, would also lead to a reduction in predisposition to anxious and depressive behaviors. The impact of the diet was assessed using behavioral tests. The Open Field Test (OFT) was used to assess locomotorization, the Elevated Plus Maze (EPM) test to assess anxious-like behavior, and the Forced Swimming Test (FST) to assess depressive-like behavior. We found that induction of T2D by the western diet did not affect the occurrence of anxious and depressive behaviors of similar behavior in mice. The occurrence of these disorders was also not influenced by gender. However, we found that WD females were more active than WD males (they were faster, walked farther distances, and spent less time at rest). Consistent with the fact that T2D induction did not affect tests for anxious and depressive-like behavior, caloric restriction did not affect anxious and depressive-like behavior. We observed the impact of habituation on some behavioral tests. In the OFT test, we observed a decrease in research behavior when repeating the test, and in the EPM test, a decrease in exploration of open arms of the labyrinth when repetitions of the test were observed.
Keywords:metabolic syndrome, diabetes, anxiety, depression, western diet, caloric restriction, behavioral tests


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