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Title:Stabilnost cinkovega oksida v gelskih strukturah in njegovo antibakterijsko delovanje : diplomsko delo univerzitetnega študijskega programa I. stopnje
Authors:ID Karlovšek, Sara (Author)
ID Leitgeb, Maja (Mentor) More about this mentor... New window
ID Kravanja, Gregor (Comentor)
ID Primožič, Mateja (Comentor)
Files:.pdf UN_Karlovsek_Sara_2020.pdf (2,79 MB)
MD5: 03A0105AA54200864C3812A9F2A54483
PID: 20.500.12556/dkum/19986081-94da-48fd-895d-46319c1e1cf8
 
Language:Slovenian
Work type:Bachelor thesis/paper
Typology:2.11 - Undergraduate Thesis
Organization:FKKT - Faculty of Chemistry and Chemical Engineering
Abstract:Namen diplomske naloge je bila sinteza antimikrobnih gelskih struktur, ki bi se lahko uporabljale v medicini za oskrbo in celjenje ran. Uporabili smo polisaharidne materiale, saj so ne toksični, biorazgradljivi in v naravi prisotni v velikih količinah. Med sintezo smo gelskim strukturam dodali nanodelce cinkovega oksida n(ZnO), saj delujejo antimikrobno. Gelske strukture smo ustrezno karakterizirali z infrardečo spektroskopijo s Fourierjevo transformacijo (FTIR), z vrstičnim elektronskim mikroskopom (ESEM), merjenjem kontaktnih kotov, vezave tekočine ter antimikrobne teste s pomočjo disk difuzne metode. Gelske strukture z različnimi deleži ZnO smo izpostavili bakterijam Escherichia coli in Staphylococcus aureus z namenom določitve njihovega antibakterijskega delovanja. Ugotovili smo, da imajo liofilizirane gelske strukture visoko stopnjo poroznosti, so hidrofilne, dobro vežejo puferske tekočine ter so v primeru kovalentnega vezanega n(ZnO) tudi antimikrobne. Za antibakterijsko delovanje je pomembna interakcija med karboksimetil skupino in Zn, ki stabilizira ujetje nanodelcev v gelski strukturi.
Keywords:cinkov oksid, gelske strukture, antibakterijsko delovanje, FTIR, ESEM
Place of publishing:Maribor
Place of performance:Maribor
Publisher:[S. Karlovšek]
Year of publishing:2020
Number of pages:XI, 35 str.
PID:20.500.12556/DKUM-77493 New window
UDC:604.4:615.281.9(043.2)
COBISS.SI-ID:32289283 New window
NUK URN:URN:SI:UM:DK:YC1142S7
Publication date in DKUM:08.10.2020
Views:996
Downloads:60
Metadata:XML DC-XML DC-RDF
Categories:KTFMB - FKKT
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Licences

License:CC BY 4.0, Creative Commons Attribution 4.0 International
Link:http://creativecommons.org/licenses/by/4.0/
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:01.09.2020

Secondary language

Language:English
Title:Stability of zinc oxide in gel structures and its antibacterial activity
Abstract:The goal of the diploma was the synthesis of antimicrobial gel structures, which could be used in medicine for healing wounds. We used polysaccharidic materials, because they aren't toxic, biologically disposable and available in nature in big amounts. We added nano particles of zinc oxide n(ZnO) to the gel structures during the synthesis, because they have antimicrobial effects. We characterised the gel structures suitably with infrared spectroscopy by using the Fourier transformation (FTIR), with a scanning electron microscope (ESEM), by measuring the contact angle, the fluid's inflection and antimicrobial tests using the disc diffusion method. To determine whether or not they are antimicrobially viable, we exposed gel structures with different amounts of ZnO to the bacteria Escherichia coli and Staphylococcus aureus. The results showed that lyophilised gel structures contain a high level of porosity, are hydrophile, join with buffer fluids very well and are antimicrobial if bonded covalently with n(ZnO). It's important for the carboxymethyl groups to interact with Zn to ensure the antimicrobial activity, which stabilizes the caught nanoparticles inside of the gel structure.
Keywords:zinc oxide, hydrogels, antibacterial activity, FTIR, ESEM


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