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Title:Vpliv ekstraktov iz naravnih materialov na metabolno aktivnost človeških melanomskih celic (WM-266-4)
Authors:Žitek, Taja (Author)
Knez Hrnčič, Maša (Mentor) More about this mentor... New window
Dariš, Barbara (Co-mentor)
Leitgeb, Maja (Co-mentor)
Files:.pdf MAG_Zitek_Taja_2018.pdf (2,52 MB)
MD5: BBDE961294CE04F216AA9C05241F270A
 
Language:Slovenian
Work type:Master's thesis/paper (mb22)
Typology:2.09 - Master's Thesis
Organization:FKKT - Faculty of Chemistry and Chemical Engineering
Abstract:Dosedanje študije so pokazale, da ima prehrana ključno vlogo pri preprečevanju kroničnih bolezni. Uživanje sadja, zelenjave, zelišč ter semen je močno povezano z manjšim tveganjem za bolezni srca in ožilja, raka, sladkorne bolezeni, Alzheimerjeve bolezni ter z zmanjšanim tveganjem za debelost. V magistrskem delu smo želeli preveriti vpliv antioksidantov, proantocianidinov in totalnih fenolov iz izbranih naravnih materialov (goji jagode, kurkuma, laneno seme, preslica, rožmarin, tropine in semena grozdja) na zmanjšanje metabolne aktivnosti rakastih celic kožnega raka. Pripravili smo raztopine izbranih naravnih materialov, jih liofilizirali in po liofilizaciji dobljenim ekstraktom izmerili koncentracijo antioksidantov, proantocianidinov in totalnih fenolov ter jih nanesli na WM-266-4 celice. Rezultati so pokazali, da so vsi ekstrakti vplivali na zaviranje rasti rakastih celic, saj so zaustavili njihovo delitev, vendar bi bile pri nekaterih ekstraktih potrebne še dodatne raziskave, še posebej pri ekstraktu lanenega semena. Najboljše rezultate pa smo zabeležili pri ekstraktu kurkume, rožmarina ter tropinah in semenu grozdja. Tem ekstraktom smo določili visok delež antioksidantov, proantocianidinov in totalnih fenolov. Predvidevamo, da je visok delež teh komponent bistven za zmanjšanje metabolne aktivnosti rakastih celic.
Keywords:antioksidanti, goji jagode, kurkuma, laneno seme, preslica, proantocianidini, rožmarin, totalni fenoli, tropine in semena grozdja, WM-266-4 celice
Year of publishing:2018
Publisher:[T. Žitek]
Source:Maribor
UDC:678.048(043.2)
COBISS_ID:21798166 New window
NUK URN:URN:SI:UM:DK:BPVAVN78
Views:759
Downloads:176
Metadata:XML RDF-CHPDL DC-XML DC-RDF
Categories:KTFMB - FKKT
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Licences

License:CC BY-SA 4.0, Creative Commons Attribution-ShareAlike 4.0 International
Link:http://creativecommons.org/licenses/by-sa/4.0/
Description:This Creative Commons license is very similar to the regular Attribution license, but requires the release of all derivative works under this same license.
Licensing start date:29.08.2018

Secondary language

Language:English
Title:The influence of extracts from natural materials on the metabolic activity of human melanoma cells (WM-266-4)
Abstract:Several studies have demonstrated that diet has a important role in the prevention of chronic diseases. The consumption of fruits, vegetables, herbs and grains is strongly associated with a lower risk of cardiovascular disease, cancer, diabetes, Alzheimer's disease and reduced risk of obesity. The main goal of the master's thesis has been to check the correlation between the content of antioxidants, proanthocyanidins and total phenolics in the selected natural materials (goji berries, turmeric, flaxseed, carrots, rosemary, troipins and grape seeds) and the reduction of the metabolic activity of skin cancer cells. The solutions of the selected natural materials were lyophilized. After lyophilization, the concentration of antioxidants, proanthocyanidins and total phenol was measured and the extract solution was applied to WM-266-4 cells. The results showed that all the extracts affected cancer cells and stopped their further divisions, but some extracts would require further research, especially the extract of flaxseed, where the metabolic activity of the cells was barely noticed. The highest reduction of the metabolic activity of cancer cells was noticed for the extracts of turmeric, rosemary and grape marc extracts. Those extracts contained high concentrations of antioxidants, proanthocyanidins and total phenolics and proofed positive effects on the reduction of the metabolic activity of cancer cells.
Keywords:antiokxidants, goji berry, curcuma, flax seed, horsetail, proanthocyanidinis, rosemary, total phenols, grape seed, WM-266-4 cell


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