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Title:Vpliv probiotikov na zdravljenje in ponovitve okužb sečil pri otrocih
Authors:ID Meštrović Popovič, Katarina (Author)
ID Marčun Varda, Nataša (Mentor) More about this mentor... New window
ID Langerholc, Tomaž (Comentor)
Files:.pdf DOK_Mestrovic_Popovic_Katarina_2023.pdf (4,04 MB)
MD5: 3601C0A4A35927EDE2B60DFB59DE668E
 
.zip DOK_Mestrovic_Popovic_Katarina_2023.zip (49,27 KB)
MD5: FCACA4D8FA22FCAC3A535DF673B671D7
 
Language:Slovenian
Work type:Doctoral dissertation
Organization:MF - Faculty of Medicine
Abstract:Okužbe sečil (OS) v otroški dobi so pogoste in lahko vodijo v pozne zapleti. Pri skoraj tretjini otrok se lahko OS ponovijo in nekateri otroci potrebujejo antibiotično zaščitno. Namen naše raziskave je bil ugotoviti, ali imajo probiotiki ugoden učinek pri zdravljenju in preprečevanju OS pri otrocih, glede na mehanizem nastanka OS in značilnosti probiotikov. Podobnih večjih raziskav na tem področju nismo zasledili. Najprej smo predklinično testirali učinkovitost nekaterih probiotikov na Escherichio coli (E. coli), najpogostejšo povzročiteljico OS in občutljivost probiotikov na antibiotike. Večina probiotikov je pokazala za polovico manjši učinek na E. coli od antibiotikov. Najoptimalnejši probiotični sev, Lactobacillus plantarum PCS 26 (PCS 26), smo nato uporabili v pilotski, dvojno slepi, randomizirani, s placebom kontrolirani, prospektivni raziskavi, v kateri smo preverjali njegovo učinkovitost pri zdravljenju in preprečevanju OS pri otrocih. Raziskava je potekala l.2016 na Otroškem odd. Splošne bolnišnice Celje. Vključili smo 30 otrok z OS, ki so med zdravljenjem in nato še pol leta prejemali probiotk/placebo. Otroci, ki so ob antibiotiku prejemali probiotik, so potrebovali 1,5 dan krajši čas antibiotičnega zdravljenja in 2 dni manj hospitalizacije. Manj otrok s probiotikom je imelo ponovitev OS. Potrebne bodo študije na večjem, bolj homogenem vzorcu otrok, za potrditev rezultatov te pilotske študije.
Keywords:probiotiki, okuţbe sečil, antibiotiĉna zašĉita, otroci, uropatogena E. coli (UPEC), Lactobacillus plantarum.
Place of publishing:Maribor
Year of publishing:2023
PID:20.500.12556/DKUM-68171-e43fb2d5-8413-02e7-f8d4-233d33c88272 New window
COBISS.SI-ID:153214467 New window
NUK URN:URN:SI:UM:DK:FQQP1LIC
Publication date in DKUM:24.05.2023
Views:607
Downloads:70
Metadata:XML RDF-CHPDL DC-XML DC-RDF
Categories:MF
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Licences

License:CC BY-NC-ND 4.0, Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
Link:http://creativecommons.org/licenses/by-nc-nd/4.0/
Description:The most restrictive Creative Commons license. This only allows people to download and share the work for no commercial gain and for no other purposes.
Licensing start date:17.05.2023

Secondary language

Language:English
Title:THE IMPACT OF PROBIOTIC SUPPLEMENTATION ON THE COURSE AND RECCURENCE OF URINARY TRACT INFECTIONS IN CHILDREN
Abstract:Urinary tract infections (UTIs) are frequent bacterial infections in childhood and can lead to chronic damage. Taking into consideration the pathogenic mechanisms associated with UTIs and the known beneficial effects of probiotics, we wanted to assess the possible beneficial/ preventive effects of probiotics on UTIs. Preclinical part of our research involved in vitro testing of some probiotics on Escherichia coli (E. coli), the main uropathogen in UTIs, and the susceptibility of probiotics to antibiotics. One probiotic strain was selected for the prospective, randomized, double-blind, placebo-controlled clinical trial. 30 children with UTI hospitalized on Pediatric Department of General Hospital Celje in 2016 were enrolled while receiving antibiotics and over the next six months of probiotic/placebo supplementation. The in vitro results showed that probiotic strains exerted similar activity against E. coli, which was about one-half the efficacy rate of the antibiotics. Clinical results showed that children on probiotic supplements required almost two days less time in hospital, and were treated with antibiotics approximately 1.5 days less than those without. Our pilot study showed that children with UTIs who received probiotics alongside classic antibiotic therapy had a noticeably milder clinical course of infection. However, better-designed studies on larger groups of children are needed.
Keywords:probiotics, urinary tract infections, antibiotic prophylaxis, child, uropathogenic E. coli (UPEC), Lactobacillus plantarum.


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