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Naslov:Comparative genome-wide analysis of small RNAs of major Gram-positive pathogens : from identification to application
Avtorji:Mraheil, Mobarak (Avtor)
Billion, André (Avtor)
Kuenne, Carsten (Avtor)
Pischimarov, Jordan (Avtor)
Kreikemayer, Bernd (Avtor)
Engelmann, Sussane (Avtor)
Hartke, Axel (Avtor)
Giard, Jean-Christophe (Avtor)
Rupnik, Maja (Avtor)
Vorwerk, Sonja (Avtor)
Beier, Markus (Avtor)
Retey, Julia (Avtor)
Hartsch, Thomas (Avtor)
Jacob, Anette (Avtor)
Cemič, Franz (Avtor)
Hemberger, Jürgen (Avtor)
Chakraborty, Trinad (Avtor)
Hain, Torsten (Avtor)
Datoteke:.pdf Microbial_Biotechnology_2010_Mraheil_et_al._Comparative_genome-wide_analysis_of_small_RNAs_of_major_Gram-positive_pathogens_from_identif.pdf (698,61 KB)
 
URL http://doi.wiley.com/10.1111/j.1751-7915.2010.00171.x
 
Jezik:Angleški jezik
Vrsta gradiva:Znanstveno delo (r2)
Tipologija:1.02 - Pregledni znanstveni članek
Organizacija:MF - Medicinska fakulteta
Opis:In the recent years, the number of drug- and multi-drug-resistant microbial strains has increased rapidly. Therefore, the need to identify innovative approaches for development of novel anti-infectives and new therapeutic targets is of high priority in global health care. The detection of small RNAs (sRNAs) in bacteria has attracted considerable attention as an emerging class of new gene expression regulators. Several experimental technologies to predict sRNA have been established for the Gram-negative model organism Escherichia coli. In many respects, sRNA screens in this model system have set a blueprint for the global and functional identification of sRNAs for Gram-positive microbes, but the functional role of sRNAs in colonization and pathogenicity for Listeria monocytogenes, Staphylococcus aureus, Streptococcuspyogenes, Enterococcus faecalis and Clostridium difficile is almost completely unknown. Here, we report the current knowledge about the sRNAs of these socioeconomically relevant Gram-positive pathogens, overview the state-of-the-art high-throughput sRNA screening methods and summarize bioinformatics approaches for genome-wide sRNA identification and target prediction. Finally, we discuss the use of modified peptide nucleic acids (PNAs) as a novel tool to inactivate potential sRNA and their applications in rapid and specific detection of pathogenic bacteria.
Ključne besede:anti-infectiveness, peptide nucleic acids, sRNA
Leto izida:2010
Št. strani:str. 658-676
Številčenje:št. 6, Letn. 3
ISSN:1751-7915
UDK:579
COBISS_ID:512101944 Povezava se odpre v novem oknu
DOI:10.1111/j.1751-7915.2010.00171.x Povezava se odpre v novem oknu
ISSN pri članku:1751-7915
Licenca:CC BY 4.0
To delo je dosegljivo pod licenco Creative Commons Priznanje avtorstva 4.0 Mednarodna
Število ogledov:70
Število prenosov:0
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Gradivo je del revije

Naslov:Microbial Biotechnology
Skrajšan naslov:Microb. Biotechnol.
Založnik:Wiley-Blackwell
ISSN:1751-7915
COBISS.SI-ID:14597398 Novo okno

Sekundarni jezik

Jezik:Slovenski jezik
Ključne besede:antiinfektivnost, peptidne nukleinske kisline, sRNA


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