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Naslov:Vesiculation of biological membrane driven by curvature induced frustrations in membrane orientational ordering
Avtorji:ID Povše Jesenek, Dalija (Avtor)
ID Perutková, Šárka (Avtor)
ID Góźdź, Wojciech (Avtor)
ID Kralj-Iglič, Veronika (Avtor)
ID Iglič, Aleš (Avtor)
ID Kralj, Samo (Avtor)
Datoteke:.pdf International_Journal_of_Nanomedicine_2013_Jesenek_et_al._Vesiculation_of_biological_membrane_driven_by_curvature_induced_frustrations_i.pdf (4,92 MB)
MD5: 1EB8EE912EADC21C2FCD37FDCC9EF960
PID: 20.500.12556/dkum/086d1dbd-8d33-4036-94f7-020f22665f3a
 
URL http://www.dovepress.com/vesiculation-of-biological-membrane-driven-by-curvature-induced-frustr-peer-reviewed-article-IJN
 
Jezik:Angleški jezik
Vrsta gradiva:Znanstveno delo (r2)
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:FNM - Fakulteta za naravoslovje in matematiko
Opis:Membrane budding often leads to the formation and release of microvesicles. The latter might play an important role in long distance cell-to-cell communication, owing to their ability to move with body fluids. Several mechanisms exist which might trigger the pinching off of globular buds from the parent membrane (vesiculation). In this paper, we consider the theoretical impacts of topological defects (frustrations) on this process in the membranes that exhibit global in-plane orientational order. A Landau–de Gennes theoretical approach is used in terms of tensor orientational order parameters. The impact of membrane shapes on position and the number of defects is analyzed. In studied cases, only defects with winding numbers m = ±1/2 appear, where we refer to the number of defects with m = 1/2 as defects, and with m = –1/2 as anti-defects. It is demonstrated that defects are attracted to regions with maximal positive Gaussian curvature, K. On the contrary, anti-defects are attracted to membrane regions exhibiting minimal negative values of K. We show on membrane structures exhibiting spherical topology that the coexistence of regions with K > 0 and K < 0 might trigger formation of defect–anti-defect pairs for strong enough local membrane curvatures. Critical conditions for triggering pairs are determined in several demonstrative cases. Then the additionally appeared anti-defects are assembled at the membrane neck, where K < 0. Consequent strong local fluctuations of membrane constituent anisotropic molecules might trigger membrane fission neck rupture, enabling a membrane fission process and the release of membrane daughter microvesicles (ie, vesiculation).
Ključne besede:structural transitions, topological defects, membrane microvesicles, membrane curvature, membrane fission, vesiculation
Leto izida:2013
Status objave pri reviji:Objavljeno
Verzija članka:Založnikova različica članka
Št. strani:str. 677-687
Številčenje:Letn. 8, št. 1
PID:20.500.12556/DKUM-67140 Novo okno
ISSN:1178-2013
UDK:577.352:61
COBISS.SI-ID:4516971 Novo okno
DOI:10.2147/IJN.S38314 Novo okno
ISSN pri članku:1178-2013
NUK URN:URN:SI:UM:DK:HETDPNP7
Datum objave v DKUM:03.08.2017
Število ogledov:880
Število prenosov:381
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
Področja:Ostalo
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Gradivo je del revije

Naslov:International journal of nanomedicine
Založnik:Dove Medical Press
ISSN:1178-2013
COBISS.SI-ID:3223828 Novo okno

Gradivo je financirano iz projekta

Financer:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:J1-4109
Naslov:Interakcije med nanodelci z različno površino in modelnimi biološkimi sistemi

Licence

Licenca:CC BY-NC 4.0, Creative Commons Priznanje avtorstva-Nekomercialno 4.0 Mednarodna
Povezava:http://creativecommons.org/licenses/by-nc/4.0/deed.sl
Opis:Licenca Creative Commons, ki prepoveduje komercialno uporabo, vendar uporabniki ne rabijo upravljati materialnih avtorskih pravic na izpeljanih delih z enako licenco.
Začetek licenciranja:03.08.2017

Sekundarni jezik

Jezik:Slovenski jezik
Ključne besede:strukturni prehodi, topološke napake, mikrovezikli membran, ukrivljenost membrane, cepitev membrane, vezikulacija


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