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Title:Vesiculation of biological membrane driven by curvature induced frustrations in membrane orientational ordering
Authors:ID Povše Jesenek, Dalija (Author)
ID Perutková, Šárka (Author)
ID Góźdź, Wojciech (Author)
ID Kralj-Iglič, Veronika (Author)
ID Iglič, Aleš (Author)
ID Kralj, Samo (Author)
Files:.pdf International_Journal_of_Nanomedicine_2013_Jesenek_et_al._Vesiculation_of_biological_membrane_driven_by_curvature_induced_frustrations_i.pdf (4,92 MB)
PID: 20.500.12556/dkum/086d1dbd-8d33-4036-94f7-020f22665f3a
URL http://www.dovepress.com/vesiculation-of-biological-membrane-driven-by-curvature-induced-frustr-peer-reviewed-article-IJN
Work type:Scientific work
Typology:1.01 - Original Scientific Article
Organization:FNM - Faculty of Natural Sciences and Mathematics
Abstract:Membrane budding often leads to the formation and release of microvesicles. The latter might play an important role in long distance cell-to-cell communication, owing to their ability to move with body fluids. Several mechanisms exist which might trigger the pinching off of globular buds from the parent membrane (vesiculation). In this paper, we consider the theoretical impacts of topological defects (frustrations) on this process in the membranes that exhibit global in-plane orientational order. A Landau–de Gennes theoretical approach is used in terms of tensor orientational order parameters. The impact of membrane shapes on position and the number of defects is analyzed. In studied cases, only defects with winding numbers m = ±1/2 appear, where we refer to the number of defects with m = 1/2 as defects, and with m = –1/2 as anti-defects. It is demonstrated that defects are attracted to regions with maximal positive Gaussian curvature, K. On the contrary, anti-defects are attracted to membrane regions exhibiting minimal negative values of K. We show on membrane structures exhibiting spherical topology that the coexistence of regions with K > 0 and K < 0 might trigger formation of defect–anti-defect pairs for strong enough local membrane curvatures. Critical conditions for triggering pairs are determined in several demonstrative cases. Then the additionally appeared anti-defects are assembled at the membrane neck, where K < 0. Consequent strong local fluctuations of membrane constituent anisotropic molecules might trigger membrane fission neck rupture, enabling a membrane fission process and the release of membrane daughter microvesicles (ie, vesiculation).
Keywords:structural transitions, topological defects, membrane microvesicles, membrane curvature, membrane fission, vesiculation
Publication status:Published
Publication version:Version of Record
Year of publishing:2013
Number of pages:str. 677-687
Numbering:Letn. 8, št. 1
PID:20.500.12556/DKUM-67140 New window
ISSN on article:1178-2013
COBISS.SI-ID:4516971 New window
DOI:10.2147/IJN.S38314 New window
Publication date in DKUM:03.08.2017
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Record is a part of a journal

Title:International journal of nanomedicine
Publisher:Dove Medical Press
COBISS.SI-ID:3223828 New window

Document is financed by a project

Funder:ARRS - Slovenian Research Agency
Project number:J1-4109
Name:Interakcije med nanodelci z različno površino in modelnimi biološkimi sistemi


License:CC BY-NC 4.0, Creative Commons Attribution-NonCommercial 4.0 International
Description:A creative commons license that bans commercial use, but the users don’t have to license their derivative works on the same terms.
Licensing start date:03.08.2017

Secondary language

Keywords:strukturni prehodi, topološke napake, mikrovezikli membran, ukrivljenost membrane, cepitev membrane, vezikulacija


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