Title: | Vesiculation of biological membrane driven by curvature induced frustrations in membrane orientational ordering |
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Authors: | ID Povše Jesenek, Dalija (Author) ID Perutková, Šárka (Author) ID Góźdź, Wojciech (Author) ID Kralj-Iglič, Veronika (Author) ID Iglič, Aleš (Author) ID Kralj, Samo (Author) |
Files: | International_Journal_of_Nanomedicine_2013_Jesenek_et_al._Vesiculation_of_biological_membrane_driven_by_curvature_induced_frustrations_i.pdf (4,92 MB) MD5: 1EB8EE912EADC21C2FCD37FDCC9EF960 PID: 20.500.12556/dkum/086d1dbd-8d33-4036-94f7-020f22665f3a
http://www.dovepress.com/vesiculation-of-biological-membrane-driven-by-curvature-induced-frustr-peer-reviewed-article-IJN
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Language: | English |
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Work type: | Scientific work |
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Typology: | 1.01 - Original Scientific Article |
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Organization: | FNM - Faculty of Natural Sciences and Mathematics
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Abstract: | Membrane budding often leads to the formation and release of microvesicles. The latter might play an important role in long distance cell-to-cell communication, owing to their ability to move with body fluids. Several mechanisms exist which might trigger the pinching off of globular buds from the parent membrane (vesiculation). In this paper, we consider the theoretical impacts of topological defects (frustrations) on this process in the membranes that exhibit global in-plane orientational order. A Landau–de Gennes theoretical approach is used in terms of tensor orientational order parameters. The impact of membrane shapes on position and the number of defects is analyzed. In studied cases, only defects with winding numbers m = ±1/2 appear, where we refer to the number of defects with m = 1/2 as defects, and with m = –1/2 as anti-defects. It is demonstrated that defects are attracted to regions with maximal positive Gaussian curvature, K. On the contrary, anti-defects are attracted to membrane regions exhibiting minimal negative values of K. We show on membrane structures exhibiting spherical topology that the coexistence of regions with K > 0 and K < 0 might trigger formation of defect–anti-defect pairs for strong enough local membrane curvatures. Critical conditions for triggering pairs are determined in several demonstrative cases. Then the additionally appeared anti-defects are assembled at the membrane neck, where K < 0. Consequent strong local fluctuations of membrane constituent anisotropic molecules might trigger membrane fission neck rupture, enabling a membrane fission process and the release of membrane daughter microvesicles (ie, vesiculation). |
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Keywords: | structural transitions, topological defects, membrane microvesicles, membrane curvature, membrane fission, vesiculation |
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Publication status: | Published |
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Publication version: | Version of Record |
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Year of publishing: | 2013 |
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Number of pages: | str. 677-687 |
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Numbering: | Letn. 8, št. 1 |
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PID: | 20.500.12556/DKUM-67140  |
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ISSN: | 1178-2013 |
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UDC: | 577.352:61 |
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ISSN on article: | 1178-2013 |
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COBISS.SI-ID: | 4516971  |
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DOI: | 10.2147/IJN.S38314  |
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NUK URN: | URN:SI:UM:DK:HETDPNP7 |
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Publication date in DKUM: | 03.08.2017 |
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Views: | 1339 |
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Downloads: | 433 |
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Metadata: |  |
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Categories: | Misc.
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