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Title:Zasnova in analiza novih polimernih oblog z vgrajenimi zdravilnimi učinkovinami na zlitini titan/aluminij/vanadij
Authors:Merslavič, Manca (Author)
Finšgar, Matjaž (Mentor) More about this mentor... New window
Maver, Uroš (Co-mentor)
Files:.pdf UN_Merslavic_Manca_2018.pdf (2,22 MB)
MD5: E19C523BD767D1CAA20FBD672EB27DBF
 
Language:Slovenian
Work type:Bachelor thesis/paper (mb11)
Typology:2.11 - Undergraduate Thesis
Organization:FKKT - Faculty of Chemistry and Chemical Engineering
Abstract:V diplomskem delu je predstavljena zasnova in analiza novih polimernih oblog, ki imajo vgrajene zdravilne učinkovine na zlitini Ti90/Al6/V4. Namen zasnove polimernih oblog je njihova potencialna uporaba v ortopedske (protetični implantanti – kolena, umetni kolki, ipd.) in zobozdravstvene namene. S pomočjo študije oblaganja vzorcev, karakterizacije tankih filmov in testiranja in vitro sproščanja, želimo spoznati možnost uporabe te zlitine v otropedski medicini, kjer bi se zdravilna učinkovina sproščala neposredno na določeno mesto in tako zagotovila ciljano sproščanje te učinkovine, prav tako pa bi bolniku pomagala pri okrevanju po operativnem posegu. Vgrajena zdravilna učinkovina sodi v skupino nesteroidnih protivnetnih učinkovin (NSAID). Rezultati študije karakterizacije vzorcev so pokazali prisotnost dveh glavnih komponent, to sta diklofenak in mešanica polimerov, kar smo potrdili s karakterizacijo tankih filmov z ATR-FTIR metodo, rezultati in vitro sproščanja pa so potrdili, da sproščanje zdravilne učinkovine vselej poteka po istem mehanizmu, in sicer v treh stopnjah: zelo hitro, hitro in zelo počasno sproščanje. Pritrdimo lahko, da se največ zdravilne učinkovine sprosti v prvih 360 minutah, kar prispeva k ciljanem odmerjanju le-te.
Keywords:zlitina titan/aluminij/vanadij, večslojne obloge, diklofenak, oblaganje z vrtenjem, in vitro sproščanje
Year of publishing:2018
Publisher:[M. Merslavič]
Source:Maribor
UDC:66.095.26:669.715(043.2)
COBISS_ID:21953302 New window
NUK URN:URN:SI:UM:DK:O3UDP8CP
Views:570
Downloads:67
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Categories:KTFMB - FKKT
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Licences

License:CC BY-NC-ND 4.0, Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
Link:http://creativecommons.org/licenses/by-nc-nd/4.0/
Description:The most restrictive Creative Commons license. This only allows people to download and share the work for no commercial gain and for no other purposes.
Licensing start date:05.07.2017

Secondary language

Language:English
Title:Development and analysis of novel polymeric coatings with integrated pharmaceutical substances on titanium/aluminium/vanadium alloy
Abstract:This bachelor thesis presents the design and analysis of new polymer coatings with integrated active substances on Ti90/Al6/V4 alloy. These polymer coatings have the potential for being used in orthopedic (prosthetic implants – artificial hips, knees, elbows, etc.) and dental purposes. With the help of case study on coating substrates, characterisation of thin films and testing in vitro release, we want to determine whether it is possible to use such materials in orthopedic medicine, where the active substance would be released directly onto specified location and thus ensure a targeted release of the substance and further also help a patient recover after surgical procedure. Integrated active substance belongs to the group of nonsteroidal anti-inflammatory drugs (NSAID). Results of the study on characterization of thin films showed presence of two main components: diclofenac and a mixture of polymers, which were confirmed with the characterization of thin films by ATR-FTIR method. The results of in vitro release state that the release of the active substance always takes place in the same mechanism in three stages: very fast release, fast release and very slow release. In conclusion, most of the active substance releases in the first 360 minutes, which contributes to targeted dosing.
Keywords:titanium/aluminium/vanadium alloy, multilayer coatings, diclofenac, spin coating, in vitro release


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