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Title:TMPRSS2:ERG gene aberrations may provide insight into pT stage in prostate cancer
Authors:ID Krstanoski, Zoran (Author)
ID Kokalj-Vokač, Nadja (Author)
ID Zagorac, Andreja (Author)
ID Pospihalj, Boris (Author)
ID Munda, Miha (Author)
ID Džeroski, Sašo (Author)
ID Golouh, Rastko (Author)
Files:.pdf BMC_Urology_2016_Krstanoski_et_al._TMPRSS2ERG_gene_aberrations_may_provide_insight_into_pT_stage_in_prostate_cancer.pdf (1,06 MB)
MD5: E38AD6B2C0AF4970A692CDF8EF508631
 
URL http://bmcurol.biomedcentral.com/articles/10.1186/s12894-016-0160-8
 
Language:English
Work type:Scientific work (r2)
Typology:1.01 - Original Scientific Article
Organization:MF - Faculty of Medicine
Abstract:Background: TMPRSS2:ERG gene aberration may be a novel marker that improves risk stratification of prostate cancer before definitive cancer therapy, but studies have been inconclusive. Methods: The study cohort consisted of 202 operable prostate cancer Slovenian patients who underwent laparoscopic radical prostatectomy. We retrospectively constructed tissue microarrays of their prostatic specimens for fluorescence in situ hybridization, with appropriate signals obtained in 148 patients for subsequent statistical analyses. Results: The following genetic aberrations were found: TMPRSS2:ERG fusion, TMPRSS2 split (a non-ERG translocation) and ERG split (an ERG translocation without involvement of TMPRSS2). TMPRSS2:ERG gene fusion happened in 63 patients (42 %), TMPRSS2 split in 12 patients and ERG split in 8 patients. Association was tested between TMPRSS2:ERG gene fusion and several clinicopathological variables, i.e., pT stage, extended lymph node dissection status, and Gleason score, correcting for multiple comparisons. Only the association with pT stage was significant at p = 0.05: Of 62 patients with pT3 stage, 34 (55 %) had TMPRSS2:ERG gene fusion. In pT3 stage patients, stronger (but not significant) association between eLND status and TMPRSS2:ERG gene fusion was detected. We detected TMPRSS2:ERG gene fusion in 64 % of the pT3 stage patients where we did not perform an extended lymph node dissection. Conclusions: Our results indicate that it is possible to predict pT3 stage at final histology from TMPRSS2:ERG gene fusion at initial core needle biopsy. FISH determination of TMPRSS2:ERG gene fusion may be particularly useful for patients scheduled to undergo a radical prostatectomy in order to improve oncological and functional results.
Keywords:FISH, predicting pT stage, radical prostatectomy, prostate cancer, TMPRSS2:ERG fusion
Year of publishing:2016
Publication status in journal:Published
Article version:Publisher's version of article
Number of pages:str. 1-6
Numbering:Letn. 16
PID:20.500.12556/DKUM-66509 New window
ISSN:1471-2490
UDC:616.65-006
ISSN on article:1471-2490
COBISS.SI-ID:29626407 New window
DOI:10.1186/s12894-016-0160-8 New window
NUK URN:URN:SI:UM:DK:GBWSL9IB
Publication date in DKUM:29.06.2017
Views:1255
Downloads:365
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Categories:Misc.
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Record is a part of a journal

Title:BMC Urology
Shortened title:BMC Urol.
Publisher:BioMed Central
ISSN:1471-2490
COBISS.SI-ID:2447380 New window

Licences

License:CC BY 4.0, Creative Commons Attribution 4.0 International
Link:http://creativecommons.org/licenses/by/4.0/
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:29.06.2017

Secondary language

Language:Slovenian
Keywords:prostata, rak (medicina), radikalna prostatektomija, geni, aberacija, TMPRSS2:ERG fuzija, fluorescentna in situ hibridizacija


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