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Naslov:Polyester type polyHIPE scaffolds with an interconnected porous structure for cartilage regeneration
Avtorji:Naranđa, Jakob (Avtor)
Sušec, Maja (Avtor)
Maver, Uroš (Avtor)
Gradišnik, Lidija (Avtor)
Gorenjak, Mario (Avtor)
Vukasović, Andreja (Avtor)
Ivković, Alan (Avtor)
Rupnik, Marjan (Avtor)
Vogrin, Matjaž (Avtor)
Krajnc, Peter (Avtor)
Datoteke:.pdf Scientific_Reports_2016_Naranda_et_al._Polyester_type_polyHIPE_scaffolds_with_an_interconnected_porous_structure_for_cartilage_regenerat.pdf (1,24 MB)
 
URL http://www.nature.com/articles/srep28695
 
Jezik:Angleški jezik
Vrsta gradiva:Znanstveno delo (r2)
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:FKKT - Fakulteta za kemijo in kemijsko tehnologijo
Opis:Development of artificial materials for the facilitation of cartilage regeneration remains an important challenge in orthopedic practice. Our study investigates the potential for neocartilage formation within a synthetic polyester scaffold based on the polymerization of high internal phase emulsions. The fabrication of polyHIPE polymer (PHP) was specifically tailored to produce a highly porous (85%) structure with the primary pore size in the range of 50–170 μm for cartilage tissue engineering. The resulting PHP scaffold was proven biocompatible with human articular chondrocytes and viable cells were observed within the materials as evaluated using the Live/Dead assay and histological analysis. Chondrocytes with round nuclei were organized into multicellular layers on the PHP surface and were observed to grow approximately 300 μm into the scaffold interior. The accumulation of collagen type 2 was detected using immunohistochemistry and chondrogenic specific genes were expressed with favorable collagen type 2 to 1 ratio. In addition, PHP samples are biodegradable and their baseline mechanical properties are similar to those of native cartilage, which enhance chondrocyte cell growth and proliferation.
Ključne besede:polyester, polymerization, polyHIPE
Leto izida:2016
Št. strani:str. 1-11
Številčenje:Letn. 6
ISSN:2045-2322
UDK:66
COBISS_ID:19662102 Povezava se odpre v novem oknu
DOI:10.1038/srep28695 Povezava se odpre v novem oknu
ISSN pri članku:2045-2322
NUK URN:URN:SI:UM:DK:7WJGSGNF
Licenca:CC BY 4.0
To delo je dosegljivo pod licenco Creative Commons Priznanje avtorstva 4.0 Mednarodna
Število ogledov:549
Število prenosov:188
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
Področja:Ostalo
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Gradivo je del revije

Naslov:Scientific Reports
Založnik:Nature Publishing Group
ISSN:2045-2322
COBISS.SI-ID:18727432 Novo okno

Gradivo je financirano iz projekta

Financer:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije (ARRS)
Številka projekta:P2-0006
Naslov:Fizikalno kemijski pojavi na površinskih plasteh in uporaba nanodelcev

Sekundarni jezik

Jezik:Slovenski jezik
Ključne besede:poliestri, polyHIPE, polimerizacija


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