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Naslov:Novel chitosan/diclofenac coatings on medical grade stainless steel for hip replacement applications
Avtorji:Finšgar, Matjaž (Avtor)
Perva-Uzunalić, Amra (Avtor)
Stergar, Janja (Avtor)
Gradišnik, Lidija (Avtor)
Maver, Uroš (Avtor)
Datoteke:.pdf Scientific_Reports_2016_Finsgar_et_al._Novel_chitosandiclofenac_coatings_on_medical_grade_stainless_steel_for_hip_replacement_applicatio.pdf (2,73 MB)
MD5: 2333A1976E1086E909A8221F20E4011D
 
URL http://www.nature.com/articles/srep26653
 
Jezik:Angleški jezik
Vrsta gradiva:Znanstveno delo (r2)
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:FKKT - Fakulteta za kemijo in kemijsko tehnologijo
Opis:Corrosion resistance, biocompatibility, improved osteointegration, as well the prevention of inflammation and pain are the most desired characteristics of hip replacement implants. In this study we introduce a novel multi-layered coating on AISI 316LVM stainless steel that shows promise with regard to all mentioned characteristics. The coating is prepared from alternating layers of the biocompatible polysaccharide chitosan and the non-steroid anti-inflammatory drug (NSAID), diclofenac. Electrochemical methods were employed to characterize the corrosion behavior of coated and uncoated samples in physiological solution. It is shown that these coatings improve corrosion resistance. It was also found that these coatings release the incorporated drug in controlled, multi-mechanism manner. Adding additional layers on top of the as-prepared samples, has potential for further tailoring of the release profile and increasing the drug dose. Biocompatibility was proven on human-derived osteoblasts in several experiments. Only viable cells were found on the sample surface after incubation of the samples with the same cell line. This novel coating could prove important for prolongation of the application potential of steel-based hip replacements, which are these days often replaced by more expensive ceramic or other metal alloys.
Ključne besede:corrosion, corrosion resistance, chitosan, biocompatibility, biomaterials, biomedical materials, coatings, stainless steel
Leto izida:2016
Št. strani:str. 1-17
Številčenje:Letn. 6
ISSN:2045-2322
UDK:57.089:669.14.018.8
COBISS_ID:19591446 Novo okno
DOI:10.1038/srep26653 Novo okno
ISSN pri članku:2045-2322
NUK URN:URN:SI:UM:DK:GRAMBIYY
Število ogledov:984
Število prenosov:299
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Področja:Ostalo
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Gradivo je del revije

Naslov:Scientific Reports
Založnik:Nature Publishing Group
ISSN:2045-2322
COBISS.SI-ID:18727432 Novo okno

Gradivo je financirano iz projekta

Financer:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije (ARRS)
Številka projekta:Z1-6737
Naslov:Razvoj zelenih mešanic korozijskih inhibitorjev za kislinske postopke vrtin v industriji pridobivanja energentov

Licence

Licenca:CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
Začetek licenciranja:23.06.2017

Sekundarni jezik

Jezik:Slovenski jezik
Ključne besede:korozija, hitozan, korozijska odpornost, biokompatibilnost, biomedicinski materiali, premazi, nerjaveče jeklo


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