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Title:Polyphenols: extraction methods, antioxidative action, bioavailability and anticarcinogenic effects
Authors:ID Brglez Mojzer, Eva (Author)
ID Knez Marevci, Maša (Author)
ID Škerget, Mojca (Author)
ID Knez, Željko (Author)
ID Bren, Urban (Author)
Files:.pdf Molecules_2016_Brglez_Mojzer_et_al._Polyphenols_Extraction_Methods,_Antioxidative_Action,_Bioavailability_and_Anticarcinogenic_Effects.pdf (1,38 MB)
MD5: CB633C5D19901AB89C27279D6C246BCC
 
URL http://www.mdpi.com/1420-3049/21/7/901
 
Language:English
Work type:Scientific work
Typology:1.01 - Original Scientific Article
Organization:FKKT - Faculty of Chemistry and Chemical Engineering
Abstract:Being secondary plant metabolites, polyphenols represent a large and diverse group of substances abundantly present in a majority of fruits, herbs and vegetables. The current contribution is focused on their bioavailability, antioxidative and anticarcinogenic properties. An overview of extraction methods is also given, with supercritical fluid extraction highlighted as a promising eco-friendly alternative providing exceptional separation and protection from degradation of unstable polyphenols. The protective role of polyphenols against reactive oxygen and nitrogen species, UV light, plant pathogens, parasites and predators results in several beneficial biological activities giving rise to prophylaxis or possibly even to a cure for several prevailing human diseases, especially various cancer types. Omnipresence, specificity of the response and the absence of or low toxicity are crucial advantages of polyphenols as anticancer agents. The main problem represents their low bioavailability and rapid metabolism. One of the promising solutions lies in nanoformulation of polyphenols that prevents their degradation and thus enables significantly higher concentrations to reach the target cells. Another, more practiced, solution is the use of mixtures of various polyphenols that bring synergistic effects, resulting in lowering of the required therapeutic dose and in multitargeted action. The combination of polyphenols with existing drugs and therapies also shows promising results and significantly reduces their toxicity.
Keywords:polyphenols, extraction, antioxidants, bioavailability, synergistic effects
Publication status:Published
Publication version:Version of Record
Year of publishing:2016
Number of pages:str. 1-38
Numbering:Letn. 21, št. 7
PID:20.500.12556/DKUM-66354 New window
ISSN:1420-3049
UDC:54
ISSN on article:1420-3049
COBISS.SI-ID:19672598 New window
DOI:10.3390/molecules21070901 New window
NUK URN:URN:SI:UM:DK:3H0NTTTR
Publication date in DKUM:22.06.2017
Views:1613
Downloads:566
Metadata:XML RDF-CHPDL DC-XML DC-RDF
Categories:Misc.
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Record is a part of a journal

Title:Molecules
Shortened title:Molecules
Publisher:MDPI
ISSN:1420-3049
COBISS.SI-ID:18462981 New window

Document is financed by a project

Funder:ARRS - Slovenian Research Agency
Project number:P2-0046
Name:Separacijski procesi in produktna tehnika

Licences

License:CC BY 4.0, Creative Commons Attribution 4.0 International
Link:http://creativecommons.org/licenses/by/4.0/
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:22.06.2017

Secondary language

Language:Slovenian
Keywords:polifenoli, ekstrakcija, antioksidanti, biološka uporabnost, sinergijski efekti


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