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Title:Highly divergent Clostridium difficile strains isolated from the environment
Authors:Janežič, Sandra (Author)
Potočnik, Mojca (Author)
Tkalec, Valerija (Author)
Rupnik, Maja (Author)
Files:.pdf PLOS_ONE_2016_Janezic_et_al._Highly_Divergent_Clostridium_difficile_Strains_Isolated_from_the_Environment.pdf (1,13 MB)
 
URL http://dx.plos.org/10.1371/journal.pone.0167101
 
Language:English
Work type:Scientific work (r2)
Typology:1.01 - Original Scientific Article
Organization:MF - Faculty of Medicine
Abstract:Clostridium difficile is one of the most important human and animal pathogens. However, the bacterium is ubiquitous and can be isolated from various sources. Here we report the prevalence and characterization of C. difficile in less studied environmental samples, puddle water (n = 104) and soil (n = 79). C. difficile was detected in 14.4% of puddle water and in 36.7% of soil samples. Environmental strains displayed antimicrobial resistance patterns comparable to already published data of human and animal isolates. A total of 480 isolates were grouped into 34 different PCR ribotypes. More than half of these (52.9%; 18 of 34) were already described in humans or animals. However, 14 PCR ribotypes were new in our PCR ribotype library and all but one were non-toxigenic. The multilocus sequence analysis of these new PCR ribotypes revealed that non-toxigenic environmental isolates are phylogenetically distinct and belong to three highly divergent clades, two of which have not been described before. Our data suggest that environment is a potential reservoir of genetically diverse population of C. difficile.
Keywords:clostridium difficile, environment, isolation
Year of publishing:2016
Number of pages:str. 1-12
Numbering:št. 11, Letn. 11
ISSN:1932-6203
UDC:579.852.13
ISSN on article:1932-6203
COBISS_ID:512659256 Link is opened in a new window
DOI:10.1371/journal.pone.0167101 Link is opened in a new window
NUK URN:URN:SI:UM:DK:R56Y6X6C
License:CC BY 4.0
This work is available under this license: Creative Commons Attribution 4.0 International
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Downloads:219
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Record is a part of a journal

Title:PloS ONE
Publisher:Public Library of Science
ISSN:1932-6203
COBISS.SI-ID:2005896 New window

Document is financed by a project

Funder:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije (ARRS)
Project no.:J3-4298
Name:Vloga okolja in gostitelja pri pojavu in razvoju okužbe s Clostridium difficile

Secondary language

Language:Slovenian
Keywords:clostridium difficile, okolje, izolacija


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