SLO | ENG

Večja pisava | Manjša pisava

Izpis gradiva

Naslov:Modeling the seasonal adaptation of circadian clocks by changes in the network structure of the suprachiasmatic nucleus
Avtorji:Bodenstein, Christian (Avtor)
Gosak, Marko (Avtor)
Schuster, Stefan (Avtor)
Marhl, Marko (Avtor)
Perc, Matjaž (Avtor)
Datoteke:.pdf PLoS_Computational_Biology_2012_Bodenstein_et_al._Modeling_the_Seasonal_Adaptation_of_Circadian_Clocks_by_Changes_in_the_Network_Structu.PDF (1005,71 KB)
 
URL http://dx.plos.org/10.1371/journal.pcbi.1002697
 
Jezik:Angleški jezik
Vrsta gradiva:Znanstveno delo (r2)
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:FNM - Fakulteta za naravoslovje in matematiko
Opis:The dynamics of circadian rhythms needs to be adapted to day length changes between summer and winter. It has been observed experimentally, however, that the dynamics of individual neurons of the suprachiasmatic nucleus (SCN) does not change as the seasons change. Rather, the seasonal adaptation of the circadian clock is hypothesized to be a consequence of changes in the intercellular dynamics, which leads to a phase distribution of electrical activity of SCN neurons that is narrower in winter and broader during summer. Yet to understand this complex intercellular dynamics, a more thorough understanding of the impact of the network structure formed by the SCN neurons is needed. To that effect, we propose a mathematical model for the dynamics of the SCN neuronal architecture in which the structure of the network plays a pivotal role. Using our model we show that the fraction of long-range cell-to-cell connections and the seasonal changes in the daily rhythms may be tightly related. In particular, simulations of the proposed mathematical model indicate that the fraction of long-range connections between the cells adjusts the phase distribution and consequently the length of the behavioral activity as follows: dense long-range connections during winter lead to a narrow activity phase, while rare long-range connections during summer lead to a broad activity phase. Our model is also able to account for the experimental observations indicating a larger light-induced phase-shift of the circadian clock during winter, which we show to be a consequence of higher synchronization between neurons. Our model thus provides evidence that the variations in the seasonal dynamics of circadian clocks can in part also be understood and regulated by the plasticity of the SCN network structure.
Ključne besede:circadian rhythms, neuronal networks, small world, structures
Leto izida:2012
Št. strani:str. 1-12
Številčenje:št. 9, Letn. 8
UDK:53
COBISS_ID:19375368 Povezava se odpre v novem oknu
DOI:10.1371/journal.pcbi.1002697 Povezava se odpre v novem oknu
Licenca:CC BY 4.0
To delo je dosegljivo pod licenco Creative Commons Priznanje avtorstva 4.0 Mednarodna
Število ogledov:43
Število prenosov:1
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
Področja:Ostalo
:
  
Skupna ocena:(0 glasov)
Vaša ocena:Ocenjevanje je dovoljeno samo prijavljenim uporabnikom.
Objavi na:Bookmark and Share

Postavite miškin kazalec na naslov za izpis povzetka. Klik na naslov izpiše podrobnosti ali sproži prenos.

Gradivo je del revije

Naslov:PLoS Computational Biology
Skrajšan naslov:PLoS Comput. Biol.
Založnik:Public Library of Science
ISSN:1553-734X
COBISS.SI-ID:512883993 Novo okno

Gradivo je financirano iz projekta

Financer:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije (ARRS)
Program financ.:Raziskovalni projekti - temeljni
Številka projekta:J1-4055
Naslov:Fizika evolucijskih procesov
Akronim:
ID projekta:info:eu-repo/grantAgreement/ARRS/Raziskovalni%20projekti%20-%20temeljni/J1-4055

Sekundarni jezik

Jezik:Slovenski jezik
Ključne besede:cirkadiani ritmi, nevronske mreže, mali svet, strukture


Komentarji

Dodaj komentar

Za komentiranje se morate prijaviti.

Komentarji (0)
0 - 0 / 0
 
Ni komentarjev!

Nazaj
Logotipi partnerjev Univerza v Mariboru Univerza v Ljubljani Univerza na Primorskem Univerza v Novi Gorici