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Izpis gradiva

Naslov:Modeling the seasonal adaptation of circadian clocks by changes in the network structure of the suprachiasmatic nucleus
Avtorji:ID Bodenstein, Christian (Avtor)
ID Gosak, Marko (Avtor)
ID Schuster, Stefan (Avtor)
ID Marhl, Marko (Avtor)
ID Perc, Matjaž (Avtor)
Datoteke:.pdf PLoS_Computational_Biology_2012_Bodenstein_et_al._Modeling_the_Seasonal_Adaptation_of_Circadian_Clocks_by_Changes_in_the_Network_Structu.PDF (1005,71 KB)
MD5: 745124DB53A994A3A015A19E2498A853
 
URL http://dx.plos.org/10.1371/journal.pcbi.1002697
 
Jezik:Angleški jezik
Vrsta gradiva:Znanstveno delo (r2)
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:FNM - Fakulteta za naravoslovje in matematiko
Opis:The dynamics of circadian rhythms needs to be adapted to day length changes between summer and winter. It has been observed experimentally, however, that the dynamics of individual neurons of the suprachiasmatic nucleus (SCN) does not change as the seasons change. Rather, the seasonal adaptation of the circadian clock is hypothesized to be a consequence of changes in the intercellular dynamics, which leads to a phase distribution of electrical activity of SCN neurons that is narrower in winter and broader during summer. Yet to understand this complex intercellular dynamics, a more thorough understanding of the impact of the network structure formed by the SCN neurons is needed. To that effect, we propose a mathematical model for the dynamics of the SCN neuronal architecture in which the structure of the network plays a pivotal role. Using our model we show that the fraction of long-range cell-to-cell connections and the seasonal changes in the daily rhythms may be tightly related. In particular, simulations of the proposed mathematical model indicate that the fraction of long-range connections between the cells adjusts the phase distribution and consequently the length of the behavioral activity as follows: dense long-range connections during winter lead to a narrow activity phase, while rare long-range connections during summer lead to a broad activity phase. Our model is also able to account for the experimental observations indicating a larger light-induced phase-shift of the circadian clock during winter, which we show to be a consequence of higher synchronization between neurons. Our model thus provides evidence that the variations in the seasonal dynamics of circadian clocks can in part also be understood and regulated by the plasticity of the SCN network structure.
Ključne besede:circadian rhythms, neuronal networks, small world, structures
Leto izida:2012
Status objave pri reviji:Objavljeno
Verzija članka:Založnikova različica članka
Št. strani:str. 1-12
Številčenje:Letn. 8, št. 9
PID:20.500.12556/DKUM-66250 Novo okno
ISSN:1553-734X
UDK:53
COBISS.SI-ID:19375368 Novo okno
DOI:10.1371/journal.pcbi.1002697 Novo okno
ISSN pri članku:1553-734X
NUK URN:URN:SI:UM:DK:EGYE0MD7
Datum objave v DKUM:16.06.2017
Število ogledov:889
Število prenosov:328
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
Področja:Ostalo
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Gradivo je del revije

Naslov:PLoS Computational Biology
Skrajšan naslov:PLoS Comput. Biol.
Založnik:Public Library of Science
ISSN:1553-734X
COBISS.SI-ID:512883993 Novo okno

Gradivo je financirano iz projekta

Financer:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije
Številka projekta:J1-4055
Naslov:Fizika evolucijskih procesov

Licence

Licenca:CC BY 4.0, Creative Commons Priznanje avtorstva 4.0 Mednarodna
Povezava:http://creativecommons.org/licenses/by/4.0/deed.sl
Opis:To je standardna licenca Creative Commons, ki daje uporabnikom največ možnosti za nadaljnjo uporabo dela, pri čemer morajo navesti avtorja.
Začetek licenciranja:16.06.2017

Sekundarni jezik

Jezik:Slovenski jezik
Ključne besede:cirkadiani ritmi, nevronske mreže, mali svet, strukture


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