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Title:Single nucleotide polymorphisms as prognostic and predictive factors of adjuvant chemotherapy in colorectal cancer of stages I and II
Authors:ID Horvat, Matej (Author)
ID Potočnik, Uroš (Author)
ID Repnik, Katja (Author)
ID Kavalar, Rajko (Author)
ID Štabuc, Borut (Author)
Files:.pdf Gastroenterology_Research_and_Practice_2016_Horvat_et_al._Single_Nucleotide_Polymorphisms_as_Prognostic_and_Predictive_Factors_of_Adjuva.pdf (1,27 MB)
MD5: EC28553651F5E911EF43A28068C1D4C2
URL http://www.hindawi.com/journals/grp/2016/2139489/
Work type:Scientific work
Typology:1.02 - Review Article
Organization:MF - Faculty of Medicine
Abstract:Colorectal cancer (CRC) is a highly heterogeneous disease regarding the stage at time of diagnosis and there is special attention regarding adjuvant chemotherapy in unselected patients with stage I and stage II. The clinicohistologically based TNM staging system with emphasis on histological evaluation of primary tumor and resected regional lymph nodes remains the standard of staging, but it has restricted sensitivity resulting in false downward stage migration. Molecular characteristics might predispose tumors to a worse prognosis and identification of those enables identifying patients with high risk of disease recurrence. Suitable predictive markers also enable choosing the most appropriate therapy. The current challenge facing adjuvant chemotherapy in stages I and II CRC is choosing patients with the highest risk of disease recurrence who are going to derive most benefit without facing unnecessary adverse effects. Single nucleotide polymorphisms (SNPs) are one of the potential molecular markers that might help us identify patients with unfavorable prognostic factors regarding disease initiation and recurrence and could determine selection of an appropriate chemotherapy regimen in the adjuvant and metastatic setting. In this paper, we discuss SNPs of genes involved in the multistep processes of cancerogenesis, metastasis, and the metabolism of chemotherapy that might prove clinically significant.
Keywords:single nucleotide polymorphism, colorectal cancer, adjuvant chemotherapy
Publication status:Published
Publication version:Version of Record
Year of publishing:2016
Number of pages:str. 1-10
Numbering:Letn. 2016
PID:20.500.12556/DKUM-66188 New window
ISSN on article:1687-630X
COBISS.SI-ID:512572984 New window
DOI:10.1155/2016/2139489 New window
Publication date in DKUM:14.06.2017
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Record is a part of a journal

Title:Gastroenterology Research and Practice
Shortened title:Gastroenterol. Res. Pract.
Publisher:Hindawi Publishing Corporation
COBISS.SI-ID:4614207 New window


License:CC BY 4.0, Creative Commons Attribution 4.0 International
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:14.06.2017

Secondary language

Keywords:enonukleotidni polimorfizem, kolorektalni rak, adjuvantna kemoterapija


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