| Title: | Single nucleotide polymorphisms as prognostic and predictive factors of adjuvant chemotherapy in colorectal cancer of stages I and II |
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| Authors: | ID Horvat, Matej (Author)
ID Potočnik, Uroš (Author)
ID Repnik, Katja (Author)
ID Kavalar, Rajko (Author)
ID Štabuc, Borut (Author) |
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| Files: |  Gastroenterology_Research_and_Practice_2016_Horvat_et_al._Single_Nucleotide_Polymorphisms_as_Prognostic_and_Predictive_Factors_of_Adjuva.pdf (1,27 MB)
MD5: EC28553651F5E911EF43A28068C1D4C2
 http://www.hindawi.com/journals/grp/2016/2139489/
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| Language: | English |
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| Work type: | Scientific work |
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| Typology: | 1.02 - Review Article |
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| Organization: | MF - Faculty of Medicine
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| Abstract: | Colorectal cancer (CRC) is a highly heterogeneous disease regarding the stage at time of diagnosis and there is special attention regarding adjuvant chemotherapy in unselected patients with stage I and stage II. The clinicohistologically based TNM staging system with emphasis on histological evaluation of primary tumor and resected regional lymph nodes remains the standard of staging, but it has restricted sensitivity resulting in false downward stage migration. Molecular characteristics might predispose tumors to a worse prognosis and identification of those enables identifying patients with high risk of disease recurrence. Suitable predictive markers also enable choosing the most appropriate therapy. The current challenge facing adjuvant chemotherapy in stages I and II CRC is choosing patients with the highest risk of disease recurrence who are going to derive most benefit without facing unnecessary adverse effects. Single nucleotide polymorphisms (SNPs) are one of the potential molecular markers that might help us identify patients with unfavorable prognostic factors regarding disease initiation and recurrence and could determine selection of an appropriate chemotherapy regimen in the adjuvant and metastatic setting. In this paper, we discuss SNPs of genes involved in the multistep processes of cancerogenesis, metastasis, and the metabolism of chemotherapy that might prove clinically significant. |
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| Keywords: | single nucleotide polymorphism, colorectal cancer, adjuvant chemotherapy |
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| Publication status: | Published |
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| Publication version: | Version of Record |
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| Year of publishing: | 2016 |
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| Number of pages: | str. 1-10 |
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| Numbering: | Letn. 2016 |
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| PID: | 20.500.12556/DKUM-66188  |
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| ISSN: | 1687-630X |
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| UDC: | 616.3-006 |
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| ISSN on article: | 1687-630X |
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| COBISS.SI-ID: | 512572984 |
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| DOI: | 10.1155/2016/2139489 |
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| NUK URN: | URN:SI:UM:DK:AOSGNBEX |
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| Publication date in DKUM: | 14.06.2017 |
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| Views: | 1434 |
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| Downloads: | 374 |
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| Metadata: |    |
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| Categories: | Misc.
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