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Title:Single nucleotide polymorphisms in genes MACC1, RAD18, MMP7 and SDF-1[alpha] as prognostic factors in resectable colorectal cancer
Authors:ID Horvat, Matej (Author)
ID Potočnik, Uroš (Author)
ID Repnik, Katja (Author)
ID Kavalar, Rajko (Author)
ID Zadnik, Vesna (Author)
ID Potrč, Stojan (Author)
ID Štabuc, Borut (Author)
Files:.pdf Radiology_and_Oncology_2016_Horvat_et_al._Single_nucleotide_polymorphisms_in_genes_MACC1,_RAD18,_MMP7_and_SDF-1a_as_prognostic_factors_i.pdf (698,90 KB)
MD5: 7F0D6D63902CC3C7A179B2D3FA5476F4
URL http://www.degruyter.com/view/j/raon.ahead-of-print/raon-2016-0043/raon-2016-0043.xml
Work type:Scientific work
Typology:1.01 - Original Scientific Article
Organization:MF - Faculty of Medicine
Abstract:Background: Colorectal cancer (CRC) represents one of the most common malignancies worldwide. Research has indicated that functional gene changes such as single nucleotide polymorphism (SNP) influence carcinogenesis and metastasis and might have an influence on disease relapse. The aim of our study was to evaluate the role of SNPs in selected genes as prognostic markers in resectable CRC. Patients and methods: In total, 163 consecutive patients treated surgically for CRC of stages I, II and III at the University Medical Centre in Maribor in 2007 and 2008 were investigated. DNA was isolated from formalin-fixed paraffin-embedded CRC tissue from the Department of Pathology and SNPs in genes SDF-1alpha, MMP7, RAD18 and MACC1 were genotyped using polymerase chain reaction followed by high resolution melting curve analysis or restriction fragment length polymorphism. Results: We found worse disease-free survival (DFS) for patients with TT genotype of SNP rs1990172 in gene MACC1 (p = 0.029). Next, we found worse DFS for patients with GG genotype for SNP rs373572 in gene RAD18 (p = 0.020). Higher frequency of genotype GG of MMP7 SNP rs11568818 was found in patients with T3/T4 stage (p = 0.014), N1/N2 stage (p = 0.041) and with lymphovascular invasion (p = 0.018). For MACC1 rs1990172 SNP we found higher frequency of genotype TT in patients with T3/T4 staging (p = 0.024). Higher frequency of genotype GG of RAD18 rs373572 was also found in patients with T1/T2 stage with disease relapse (p = 0.041). Conclusions: Our results indicate the role of SNPs as prognostic factors in resectable CRC.
Keywords:single nucleotide polymorphism, colorectal cancer, MACC1, RAD18, MMP7, SDF-1a
Publication status:Published
Publication version:Version of Record
Year of publishing:2016
Number of pages:9 str.
PID:20.500.12556/DKUM-65442 New window
ISSN on article:1581-3207
COBISS.SI-ID:512631096 New window
DOI:10.1515/raon-2016-0043 New window
Publication date in DKUM:05.04.2017
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Record is a part of a journal

Title:Radiology and oncology
Publisher:Association of Radiology and Oncology
COBISS.SI-ID:784507 New window


License:CC BY-NC-ND 4.0, Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
Description:The most restrictive Creative Commons license. This only allows people to download and share the work for no commercial gain and for no other purposes.
Licensing start date:05.04.2017

Secondary language

Keywords:enonukleotidni polimorfizem, kolorektalni rak, MACC1, RAD18, MMP7, SDF-1a


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