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Naslov:Prognostic factors of choroidal melanoma in Slovenia, 1986-2008
Avtorji:Jančar, Boris (Avtor)
Budihna, Marjan (Avtor)
Drnovšek-Olup, Brigita (Avtor)
Novak-Andrejčič, Katrina (Avtor)
Brovet-Zupančič, Irena-Hedvika (Avtor)
Pahor, Dušica (Avtor)
Datoteke:.pdf Radiology_and_Oncology_2016_Jancar_et_al._Prognostic_factors_of_choroidal_melanoma_in_Slovenia,_1986-2008.pdf (650,78 KB)
MD5: 7F875AB0FC2B7EBF53CE8EF4460A7302
 
URL https://www.degruyter.com/view/j/raon.2016.50.issue-1/raon-2015-0009/raon-2015-0009.xml?rskey=w2u59H&result=1&q=Prognostic+factors+of+choroidal+melanoma+in+Slovenia%2C+1986-2008
 
Jezik:Angleški jezik
Vrsta gradiva:Znanstveno delo (r2)
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:MF - Medicinska fakulteta
Opis:Introduction: Choroidal melanoma is the most common primary malignancy of the eye, which frequently metastasizes. The Cancer Registry of Slovenia reported the incidence of choroid melanoma from 1983 to 2009 as stable, at 7.8 cases/million for men and 7.4/million for women. The aim of the retrospective study was to determinate the prognostic factors of survival for choroidal melanoma patients in Slovenia. Patients and methods: From January 1986 to December 2008 we treated 288 patients with malignant choroidal melanoma; 127 patients were treated by brachytherapy with beta rays emitting ruthenium-106 applicators; 161 patients were treated by enucleation. Results: Patients with tumours thickness < 7.2 mm and base diameter < 16 mm were treated by brachytherapy and had 5- and 10-year overall mortality 13% and 32%, respectively. In enucleated patients, 5- and 10-year mortality was higher, 46% and 69%, respectively, because their tumours were larger. Thirty patients treated by brachytherapy developed local recurrence. Twenty five of 127 patients treated by brachytherapy and 86 of 161 enucleated patients developed distant metastases. Patients of age >/= 60 years had significantly lower survival in both treatment modalities. For patients treated by brachytherapy the diameter of the tumour base and treatment time were independent prognostic factors for overall survival, for patients treated by enucleation age and histological type of tumour were independent prognosticators. In first few years after either of treatments, the melanoma specific annual mortality rate increased, especially in older patients, and then slowly decreased. Conclusions: It seems that particularly younger patients with early tumours can be cured, whereby preference should be given to eyesight preserving brachytherapy over enucleation.
Ključne besede:choroidal melanoma, therapy, brachytherapy, prognostic factors
Leto izida:2016
Št. strani:str. 104-112, VII
Številčenje:št. 1, Letn. 50
ISSN:1318-2099
UDK:617.721.6-006
COBISS_ID:31864281 Novo okno
DOI:10.1515/raon-2015-0009 Novo okno
ISSN pri članku:1318-2099
NUK URN:URN:SI:UM:DK:LAB932UJ
Število ogledov:489
Število prenosov:251
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
Področja:Ostalo
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Gradivo je del revije

Naslov:Radiology and Oncology
Skrajšan naslov:Radiol. Oncol.
Založnik:De Gruyter Open
ISSN:1318-2099
COBISS.SI-ID:32649472 Novo okno

Licence

Licenca:CC BY-NC-ND 4.0, Creative Commons Priznanje avtorstva-Nekomercialno-Brez predelav 4.0 Mednarodna
Povezava:http://creativecommons.org/licenses/by-nc-nd/4.0/deed.sl
Opis:Najbolj omejujoča licenca Creative Commons. Uporabniki lahko prenesejo in delijo delo v nekomercialne namene in ga ne smejo uporabiti za nobene druge namene.
Začetek licenciranja:05.04.2017

Sekundarni jezik

Jezik:Slovenski jezik
Ključne besede:melanom, žilnica, terapija, brahiterapija, napovedni dejavniki


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