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Naslov:Polymorphism of the IL13 gene may be associated with uterine leiomyomas in Slovenian women
Avtorji:ID Krsteski, Jovan (Avtor)
ID Jurgec, Staša (Avtor)
ID Pakiž, Maja (Avtor)
ID But, Igor (Avtor)
ID Potočnik, Uroš (Avtor)
Datoteke:.pdf Balkan_Journal_of_Medical_Genetics_2016_Krsteski_et_al._Polymorphism_of_the_IL13_gene_may_be_associated_With_Uterine_leiomyomas_in_Slove.pdf (478,01 KB)
MD5: 605E63C8907EF21C5BA024E4B2DF6BEC
 
URL http://www.degruyter.com/view/j/bjmg.2016.19.issue-2/bjmg-2016-0036/bjmg-2016-0036.xml
 
Jezik:Angleški jezik
Vrsta gradiva:Znanstveno delo
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:MF - Medicinska fakulteta
Opis:Uterine leiomyomas (ULM) are a common cause of solid pelvic tumors in women. Their etiopathogenesis remains unclear. Interleukins (ILs) and their receptors can influence tumor biology of ULM. The aim of this study was to evaluate single nucleotide polymorphisms (SNPs) exhibited in the genes IL4 (rs2070874), IL4R (rs1801275), IL12RB1 (rs11575934), IL12B (rs6887695), IL13 (rs20541) and IL23R (rs7517847) as risk factors for ULM in Slovenian women and to identify associations between corresponding clinical parameters and the analyzed SNPs. In addition, solitary and multiple ULM were compared to identify clinical and/or genetic parameters influencing their occurrence. We conducted a case-control study that included 181 women with leiomyomas and 133 control subjects. Genotyping of selected SNPs was performed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and high resolution melting (HRM) techniques. The TT genotype of rs20541 (IL13) was significantly associated with decreased risk of ULM compared to both the CC and CT genotypes [p = 0.018; odds ratio (OR) = 0.184; 95% confidence interval (95% CI) = 0.048-0.7121. Using genetic and clinical data to develop a predictive model with logistic regression, we found that adenomyosis, higher age at diagnosis, family history of ULM occurrence, earlier menarche, lower number of pregnancies and lower age at first sexual intercourse, the G allele and genotypes AG and GG of rs1801275 (IL4R) were associated with an increased risk of multiple ULM occurrence. We also found an association between rs20541 (IL13) and 17ß-estradiol serum levels in patients with multiple ULM (p 0.003). Our study showed, for the first time, that rs20541 (IL13) may contribute to susceptibility of ULM development and that rs1801275 (IL4R) can predispose patients to develop multiple ULM.
Ključne besede:genetic risk, uterine leiomyomas, ULM, single nucleotide polymorphism (SNP), IL13 gene
Status publikacije:Objavljeno
Verzija publikacije:Objavljena publikacija
Leto izida:2016
Št. strani:str. 51-60
Številčenje:Letn. 19, št. 2
PID:20.500.12556/DKUM-65322 Novo okno
ISSN:1311-0160
UDK:618.14:575.11
COBISS.SI-ID:512682552 Novo okno
DOI:10.1515/bjmg-2016-0036 Novo okno
ISSN pri članku:1311-0160
NUK URN:URN:SI:UM:DK:DTJOSHWF
Datum objave v DKUM:30.03.2017
Število ogledov:1511
Število prenosov:344
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
Področja:Ostalo
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Vaša ocena:Ocenjevanje je dovoljeno samo prijavljenim uporabnikom.
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Gradivo je del revije

Naslov:Balkan Journal of Medical Genetics
Skrajšan naslov:Balk. J. Med. Genet.
Založnik:De Gruyter Open
ISSN:1311-0160
COBISS.SI-ID:21017133 Novo okno

Licence

Licenca:CC BY-NC-ND 4.0, Creative Commons Priznanje avtorstva-Nekomercialno-Brez predelav 4.0 Mednarodna
Povezava:http://creativecommons.org/licenses/by-nc-nd/4.0/deed.sl
Opis:Najbolj omejujoča licenca Creative Commons. Uporabniki lahko prenesejo in delijo delo v nekomercialne namene in ga ne smejo uporabiti za nobene druge namene.
Začetek licenciranja:30.03.2017

Sekundarni jezik

Jezik:Slovenski jezik
Ključne besede:genetsko tveganje, leiomiom maternice, gen IL13, enonukleotidni polimorfizem (SNP)


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