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Title:Early predictors of 30-day mortality in non-ST-elevation acute coronary syndrome patients
Authors:ID Rožič, Suzana (Author)
ID Županić, Melanija (Author)
ID Sinkovič, Andreja (Author)
Files:.pdf Zdravniski_vestnik_2008_Rozic,_Zupanic,_Sinkovic_EARLY_PREDICTORS_OF_30-DAY_MORTALITY_IN_NON-ST-ELEVATION_ACUTE_CORONARY_SYNDROME_PATIEN.pdf (111,63 KB)
MD5: B6950EF4402F4B7093758D4E1773BFC2
 
URL http://vestnik.szd.si/index.php/ZdravVest/article/view/499
 
Language:English
Work type:Scientific work
Typology:1.01 - Original Scientific Article
Organization:MF - Faculty of Medicine
Abstract:Background: The incidence of non-ST-elevation acute coronary syndrome (ACS), including unstable angina pectoris and non-ST-elevation myocardial infarction (MI), is increasing in comparison to ST-elevation ACS. Our aim was to evaluate predictive role of admission variables for 30-day mortality in non-ST-elevation ACS patients. Patients and methods: We retrospectively analysed the data of 415 patients, admitted to University Clinical Center Maribor in 2006 due to non-ST-elevation ACS. Inclusion criteria were rest chest pain, ECG changes (ST-segment depression > or = 0.1 mV, and/or negative T wave > or = 0.1 mV and/or pathologic Q and/or non-specific ECG) and/or increased troponin T levels. Predictors of 30-day mortality were analysed by univariate and multivariate logistic regression. Results: 30-day mortality was 4.3 %. Between nonsurvivors and survivors there were significant differences in mean age, the incidence of arterial hypertension, positive family history of coronary artery disease, in mean admission systolic and diastolic blood pressure, pulse, mean admission troponin T, leukocyte count, CRP, creatinine and the incidence of admission heart failure. Multivariate logistic regression proved that most significant independent early predictor of 30-day mortality was admission heart failure (OR 41.21, 95 % CI 3.50 to 484.66, p = 0.003), followed by admission serum creatinine (OR 0.989, 95 % CI 0.981 to 0.997, p = 0.008) and troponin T (OR 0.263, 95 % CI 0.080 to 0.861). Conclusion: Most significant independent predictor of 30-day mortality of patients with non-ST-elevation ACS, being 4.5 %, was heart failure on admission.
Keywords:mortality, non-ST-elevation acute coronary syndrome, predictors
Publication status:Published
Publication version:Version of Record
Year of publishing:2008
Number of pages:str. 553-560
Numbering:Letn. 77, št. 9
PID:20.500.12556/DKUM-65266 New window
ISSN:1318-0347
UDC:616.12
ISSN on article:1318-0347
COBISS.SI-ID:3094079 New window
NUK URN:URN:SI:UM:DK:QXN8K6X9
Publication date in DKUM:27.03.2017
Views:1379
Downloads:97
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Categories:Misc.
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Record is a part of a journal

Title:Zdravniški vestnik. glasilo Slovenskega zdravniškega društva
Publisher:Slovensko zdravniško društvo
ISSN:1318-0347
COBISS.SI-ID:32893696 New window

Licences

License:CC BY-NC 4.0, Creative Commons Attribution-NonCommercial 4.0 International
Link:http://creativecommons.org/licenses/by-nc/4.0/
Description:A creative commons license that bans commercial use, but the users don’t have to license their derivative works on the same terms.
Licensing start date:27.03.2017

Secondary language

Language:Slovenian
Title:Zgodnji dejavniki tveganja za 30-dnevno umrljivost bolnikov z akutnim koronarnim sindromom brez dviga veznice ST
Abstract:Izhodišča: Akutni korornarni sindrom (AKS) brez dviga veznice ST je vse pogostejši. Naš cilj je oceniti pomen zgodnjih dejavnikov za smrt znotraj 30 dni pri bolnikih z AKS brez dviga veznice ST. Bolniki in metode: Retrospektivno smo obdelali podatke 415 bolnikov, sprejetih v 2006 v Univerzitetni klinični center Maribor zaradi AKS brez dviga veznice ST. Ob prsni bolečini v mirovanju so imeli bolniki značilne EKG spremembe (znižanje veznice ST več ali enako 0,1 mV in/ali negativni val T večji ali enak 0,1 mV in/ali patološki val Q in/ali nespecifični EKG) in/ali dvig troponina T. Zgodnja napovedna vrednost spremenljivk za 30-dnevno umrljivost je bila ocenjena z univariantno in multivariantno statistično metodo. Rezultati: 30-dnevna umrljivost je bila 4,3 %. Med umrlimi in preživelimi smo ugotavljali statistično pomembne razlike v povprečni starosti, pogostnosti arterijske hipertenzije, pozitivne družinske anamneze koronarne koronarne bolezni, povprečni vrednosti sprejemnega sistoličnega in diastoličnega krvnega tlaka, pulza, troponina T, števila levkocitov, CRP in kreatinina ter vpogostnosti srčnega popuščanja ob sprejemu. Multivariantna logistična regresija je pokazala, da je najpomembnejši zgodnji dejavnik tveganja za 30-dnevno umrljivost prisotnost srčnega popuščanja ob sprejemu (OR 41,21,95 % CI 3,50 do 484,66, p=0,003), nato sprejemna vrednost kreatinina (OR 0,989, 95 % CI 0,981 do 0,997, p=0,008) in troponina T (OR 0,263,95 % CI 0,080 do 0,861, p=0,027). Zaključki: Najpomembnejši neodvisni dejavnik tveganja za 30-dnevno umrljivost bolnikov z AKS brez trajnega dviga veznice ST, ki je bila 4,3 %, je prisotnost srčnega popuščanja ob sprejemu v bolnišnico.
Keywords:umrljivost, akutni koronarni sindrom brez dviga ST, dejavniki tveganja


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