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Title:ANALIZA SISTEMOV ZA DOSTAVO ZDRAVILNIH UČINKOVIN IZ MEDICINSKIH IMPLANTATOV
Authors:Žižek, Marko (Author)
Finšgar, Matjaž (Mentor) More about this mentor... New window
Maver, Uroš (Co-mentor)
Files:.pdf MAG_Zizek_Marko_2016.pdf (4,52 MB)
MD5: A96189A575E2DD997407C51CF2276064
 
Language:Slovenian
Work type:Master's thesis/paper (mb22)
Typology:2.09 - Master's Thesis
Organization:FKKT - Faculty of Chemistry and Chemical Engineering
Abstract:V magistrskem delu je predstavljen postopek oblaganja medicinskega nerjavnega jekla AISI 316 LVM, iz katerega so narejeni protetični implantati, kot so umetni kolki, kolena in podobno. Zaščitne obloge so večslojne, vmes pa so sloji zdravilne učinkovine. Ta se sprošča v mediju, ki je podoben človeškim tekočinam. S pomočjo študij korozije, sproščanja in biokompatibilnosti želimo spoznati možnost uporabe takega materiala v ortopedski medicini, kjer bi se protibolečinska zdravilna učinkovina sproščala direktno, na samem mestu posega. S tem bi bilo možno doseči bolj učinkovito zdravljenje, saj bi dostava zdravilne učinkovine bila ciljana, hkrati pa bi se izboljšala kvaliteta življenja bolnika po prebujanju. Slednje bi bila tudi dobra podlaga za nadaljnje uspešno zdravljenje, saj vemo, da se manj boleče okrevanje povezuje tudi z izboljšanim celjenjem ran. Vgrajena protibolečinska učinkovina iz skupine nesteroidnih protivnetnih zdravil (NSAID) ima tudi protivnetni učinek, ki v začetni fazi po vgradnji implantata lahko prepreči njegovo zavrnitev s strani telesa. Rezultati študije korozije z elektrokemijskimi metodami kažejo pri vseh obloženih modelih odsotnost difuzije in povečanje korozijske upornosti glede na neobložen vzorec. Iz rezultatov in vitro sproščanja je razvidno, da sproščanje v vseh sistemih poteka po istem mehanizmu v treh stopnjah: pospešeno sproščanje, hitro sproščanje in zelo počasno sproščanje. Večina zdravilne učinkovine se sprosti že v prvih 360 minutah, ne glede na koncentracijo, kar omogoča ciljano odmerjanje. V testiranju biokompatibilnosti smo odkrili tudi, da takšne obloge niso samo biokompatibilne, ampak tudi spodbujajo rast osteoblastnih celic, kar omogoča hitrejše in učinkovitejše okrevanje.
Keywords:nerjavno jeklo AISI 316LVM, pasivacija, diklofenak, hitozan, večslojne prevleke, oblaganje z vrtenjem, korozija, in vitro sproščanje, biokompatibilnost
Year of publishing:2016
Publisher:[M. Žižek]
Source:Maribor
UDC:669.14.018.62:57.089.6(043.2)
COBISS_ID:20355350 New window
NUK URN:URN:SI:UM:DK:ZNIMQTBK
Views:1576
Downloads:194
Metadata:XML RDF-CHPDL DC-XML DC-RDF
Categories:KTFMB - FKKT
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Secondary language

Language:English
Title:ANALYSIS OF DRUG DELIVERY SYSTEMS FROM MEDICAL IMPLANTS
Abstract:In this Master's thesis we present the coating procedure of AISI 316LVM stainless steel, from which prosthetic implants in the form of artificial hips and knees are made. The coatings are multilayered and contain layers of a drug that is released into a medium similar to human fluids. The thesis is an attempt to establish the possibility of using such materials inorthopedic medicine, where an analgesic drug would be released directly in the area of the procedure. This could lead to more effective treatment, since the drug delivery would be targeted. Also, the patient's quality of life after waking up would be improved. This would be a good basis for further effective treatment, since it is known that a less painful recovery is connected to better wound healing. The integrated drug from the group of non-steroid anti-inflammatory drugs (NSAID) also has an inflammatory effect that could prevent the rejection of the implant in the first phase after the insertion. The results of the electrochemical corrosion study show the absence of diffusion and an increase in resistance towards corrosion in all the coated samples in comparison to the blank sample. The in vitro release testing shows that the release in all samples follows the same three step mechanism: »burst« release, fast release and »plateau« release. Most of the drug is released in the first 360 minutes, regardless of the concentration., which allows controlled and targeted dosage. In the biocompatiblity testing we discovered the coated samples are not only biocompatible, but they also promote the growth of osteoblast cells, which allows faster and more effective healing.
Keywords:stainless steel AISI 316LVM, passivation, diclofenac, chitosane, spin coating, multilayer coating, corosion, in vitro release, biocompatibility


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