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Izpis gradiva

Naslov:Functional connectivity in islets of Langerhans from mouse pancreas tissue slices
Avtorji:Gosak, Marko (Avtor)
Stožer, Andraž (Avtor)
Korošak, Dean (Avtor)
Rupnik, Marjan (Avtor)
Marhl, Marko (Avtor)
Perc, Matjaž (Avtor)
Dolenšek, Jurij (Avtor)
Datoteke:.pdf PLoS_Computational_Biology_2013_Stozer_et_al._Functional_Connectivity_in_Islets_of_Langerhans_from_Mouse_Pancreas_Tissue_Slices.PDF (798,57 KB)
 
URL http://dx.plos.org/10.1371/journal.pcbi.1002923
 
Jezik:Angleški jezik
Vrsta gradiva:Znanstveno delo (r2)
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:MF - Medicinska fakulteta
Opis:We propose a network representation of electrically coupled beta cells in islets of Langerhans. Beta cells are functionally connected on the basis of correlations between calcium dynamics of individual cells, obtained by means of confocal laser-scanning calcium imaging in islets from acute mouse pancreastissue slices. Obtained functional networks are analyzed in the light of known structural and physiological properties of islets. Focusing on the temporal evolution of the network under stimulation with glucose, we show thatthe dynamics are more correlated under stimulation than under non-stimulated conditions and that the highest overall correlation, largely independent of Euclidean distances between cells, is observed in the activation and deactivation phases when cells are driven by the external stimulus. Moreover, we find that the range of interactions in networks during activity shows a clear dependence on the Euclidean distance, lending support to previous observations that beta cells are synchronized via calcium waves spreading throughout islets. Most interestingly, the functional connectivity patterns between beta cells exhibit small-world properties, suggesting that beta cells do not form a homogeneous geometric network but are connected in a functionally more efficient way. Presented results provide support for the existing knowledge of beta cell physiology from a network perspective and shedimportant new light on the functional organization of beta cell syncitia whose structural topology is probably not as trivial as believed so far.
Ključne besede:islets of Langerhans, mouse pancreas
Leto izida:2013
Št. strani:str. 1-12
Številčenje:št. 2, Letn. 9
UDK:612.349.7
COBISS_ID:512264760 Povezava se odpre v novem oknu
DOI:10.1371/journal.pcbi.1002923 Povezava se odpre v novem oknu
Licenca:CC BY 4.0
To delo je dosegljivo pod licenco Creative Commons Priznanje avtorstva 4.0 Mednarodna
Število ogledov:42
Število prenosov:0
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
Področja:Ostalo
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Skupna ocena:(0 glasov)
Vaša ocena:Ocenjevanje je dovoljeno samo prijavljenim uporabnikom.
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Gradivo je del revije

Naslov:PLoS Computational Biology
Skrajšan naslov:PLoS Comput. Biol.
Založnik:Public Library of Science
ISSN:1553-734X
COBISS.SI-ID:512883993 Novo okno

Gradivo je financirano iz projekta

Financer:ARRS - Agencija za raziskovalno dejavnost Republike Slovenije (ARRS)
Program financ.:Raziskovalni projekti - temeljni
Številka projekta:P3-0310
Naslov:Celična fiziologija
Akronim:
ID projekta:info:eu-repo/grantAgreement/ARRS/Raziskovalni%20projekti%20-%20temeljni/P3-0310

Sekundarni jezik

Jezik:Slovenski jezik
Ključne besede:Langerhansovi otočki, trebušna slinavka miši


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