| Naslov: | Functional connectivity in islets of Langerhans from mouse pancreas tissue slices |
|---|
| Avtorji: | ID Stožer, Andraž (Avtor)
ID Gosak, Marko (Avtor)
ID Dolenšek, Jurij (Avtor)
ID Perc, Matjaž (Avtor)
ID Marhl, Marko (Avtor)
ID Rupnik, Marjan (Avtor)
ID Korošak, Dean (Avtor) |
|---|
| Datoteke: |  PLoS_Computational_Biology_2013_Stozer_et_al._Functional_Connectivity_in_Islets_of_Langerhans_from_Mouse_Pancreas_Tissue_Slices.PDF (798,57 KB)
MD5: FD2A5320E9D4122CAE4F9A9470E5CE08
 http://dx.plos.org/10.1371/journal.pcbi.1002923
|
|---|
| Jezik: | Angleški jezik |
|---|
| Vrsta gradiva: | Znanstveno delo |
|---|
| Tipologija: | 1.01 - Izvirni znanstveni članek |
|---|
| Organizacija: | MF - Medicinska fakulteta
|
|---|
| Opis: | We propose a network representation of electrically coupled beta cells in islets of Langerhans. Beta cells are functionally connected on the basis of correlations between calcium dynamics of individual cells, obtained by means of confocal laser-scanning calcium imaging in islets from acute mouse pancreastissue slices. Obtained functional networks are analyzed in the light of known structural and physiological properties of islets. Focusing on the temporal evolution of the network under stimulation with glucose, we show thatthe dynamics are more correlated under stimulation than under non-stimulated conditions and that the highest overall correlation, largely independent of Euclidean distances between cells, is observed in the activation and deactivation phases when cells are driven by the external stimulus. Moreover, we find that the range of interactions in networks during activity shows a clear dependence on the Euclidean distance, lending support to previous observations that beta cells are synchronized via calcium waves spreading throughout islets. Most interestingly, the functional connectivity patterns between beta cells exhibit small-world properties, suggesting that beta cells do not form a homogeneous geometric network but are connected in a functionally more efficient way. Presented results provide support for the existing knowledge of beta cell physiology from a network perspective and shedimportant new light on the functional organization of beta cell syncitia whose structural topology is probably not as trivial as believed so far. |
|---|
| Ključne besede: | islets of Langerhans, mouse pancreas |
|---|
| Status publikacije: | Objavljeno |
|---|
| Verzija publikacije: | Objavljena publikacija |
|---|
| Leto izida: | 2013 |
|---|
| Št. strani: | str. 1-12 |
|---|
| Številčenje: | Letn. 9, št. 2 |
|---|
| PID: | 20.500.12556/DKUM-60111  |
|---|
| ISSN: | 1553-734X |
|---|
| UDK: | 612.349.7 |
|---|
| COBISS.SI-ID: | 512264760 |
|---|
| DOI: | 10.1371/journal.pcbi.1002923 |
|---|
| ISSN pri članku: | 1553-734X |
|---|
| NUK URN: | URN:SI:UM:DK:BGZBJU99 |
|---|
| Datum objave v DKUM: | 16.06.2017 |
|---|
| Število ogledov: | 1540 |
|---|
| Število prenosov: | 417 |
|---|
| Metapodatki: |    |
|---|
| Področja: | Ostalo
|
|---|
|
:
|
Kopiraj citat |
|---|
| | | | Skupna ocena: | (0 glasov) |
|---|
| Vaša ocena: | Ocenjevanje je dovoljeno samo prijavljenim uporabnikom. |
|---|
| Objavi na: |  |
|---|
Postavite miškin kazalec na naslov za izpis povzetka. Klik na naslov izpiše
podrobnosti ali sproži prenos. |
