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Title:Raznolikost v farmakološkem odzivu na zdravljenje z metforminom
Authors:ID Ornik, Vanja (Author)
ID Ferk, Polonca (Author)
Files:.pdf Zdravniski_vestnik_2013_Ornik,_Ferk_Raznolikost_v_farmakoloskem_odzivu_na_zdravljenje_z_metforminom.pdf (175,58 KB)
MD5: AD37CAC8495DDD61CB405A4B6F28EDE8
 
URL http://vestnik.szd.si/index.php/ZdravVest/article/view/667
 
Language:Slovenian
Work type:Scientific work (r2)
Typology:1.02 - Review Article
Organization:MF - Faculty of Medicine
Abstract:Izhodišča: Metformin je peroralni antidiabetik in je po slovenskih smernicah zdravilo prve izbire za zdravljenje sladkorne bolezni tipa 2 (SB2). Svoje mesto si utira tudi pri zdravljenju sindroma policističnih jajčnikov (PCOS), čeprav PCOS (še) ni uradno med indikacijami za zdravljenje z metforminom. Študije kažejo, da metformin izboljša klinično in biokemično sliko PCOS ter zveča stopnjo ovulacije in s tem verjetnost za zanositev pri ženskah s tem sindromom. Farmakološki učinki metformina se ob enakem režimu odmerjanja med bolniki razlikujejo, kar poskušamo med drugim razložiti tudi z vplivom polimorfnih različic v genih, povezanih s farmakodinamiko in farmakokinetiko metformina. Zaključki: Rezultati raziskav kažejo, da polimorfne različice v genih, povezanih s farmakodinamiko in farmakokinetiko metformina, lahko prispevajo k raznolikosti v odzivu na zdravljenje z metforminom tako pri bolnikih s SB2 kot pri bolnicah s PCOS.
Keywords:farmakogenetika, sladkorna bolezen tipa 2, sindrom policističnih jajčnikov, genetski polimorfizmi, farmakoterapija
Year of publishing:2013
Publication status in journal:Published
Article version:Publisher's version of article
Number of pages:str. 487-496
Numbering:št. 7/8, Letn. 82
PID:20.500.12556/DKUM-56928 New window
ISSN:1318-0347
UDC:615.2:616.379-008.64
ISSN on article:1318-0347
COBISS.SI-ID:512342840 New window
NUK URN:URN:SI:UM:DK:RVUV6TKB
Publication date in DKUM:30.12.2015
Views:1456
Downloads:99
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Categories:Misc.
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Record is a part of a journal

Title:Zdravniški vestnik
Publisher:Slovensko zdravniško društvo
ISSN:1318-0347
COBISS.SI-ID:32893696 New window

Licences

License:CC BY-NC 4.0, Creative Commons Attribution-NonCommercial 4.0 International
Link:http://creativecommons.org/licenses/by-nc/4.0/
Description:A creative commons license that bans commercial use, but the users don’t have to license their derivative works on the same terms.
Licensing start date:30.12.2015

Secondary language

Language:English
Title:Variability in pharmacological response to metformin treatment
Abstract:Background: According to the Slovenian guidelines, metformin, an oral antidiabetic drug, is a drug of choice for the treatment of type 2 diabetes. Additionally, metformin is paving its way in polycystic ovary syndrome (PCOS) treatment, although the drug has not (yet) been officially indicated to treat PCOS. Studies have shown that metformin improves clinical and biochemical features of PCOS as well as the rate of ovulation and consequently the likelihood of conception in PCOS women. At the same dosage regimen, pharmacological effects of metformin show interindividual variability in metformin response; efforts have been made to at least partly explain the variability with polymorphic variants in genes related to metformin pharmacodynamics and pharmacokinetics. Conclusions: The results of the current studies indicate that polymorphic variants in genes related to metformin pharmacodynamics and pharmacokinetics may contribute to the interindividual variability in pharmacological response to metformin treatment in diabetic as well as in PCOS patients.
Keywords:pharmacogenetics, type 2 diabetes, polycystic ovary syndrome, genetic polymorphisms, pharmacotherapy


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