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Title:Potential of phenolic antioxidants
Authors:ID Ružić, Iva (Author)
ID Škerget, Mojca (Author)
ID Knez, Željko (Author)
Files:.pdf Acta_Chimica_Slovenica_2010_Ruzic,_Skerget,_Knez_Potential_of_phenolic_antioxidants.pdf (250,25 KB)
MD5: 9E55B3FE8CF6765B9894B965B0AB4ED2
 
URL http://acta-arhiv.chem-soc.si/57/57-2-263.pdf
 
Language:English
Work type:Scientific work
Typology:1.02 - Review Article
Organization:FKKT - Faculty of Chemistry and Chemical Engineering
Abstract:In vitro studies have shown a link between the consumption of food rich in (poly)phenols, especially flavonoids, and reduced risk of coronary heart diseases. Several flavonoids have been reported to prevent low density lipoprotein cholesterol oxidation in vitro. The aim of our work was to determine antioxidant and radical scavenging activity of flavonoids myricetin,quercetin, rutin, luteolin, apigenin, kaempferol, catechin, epicatechin and epigallocatechin gallate and to study the influence of chemical structure and flavonoid interactions on the ability to inhibit oxidation and scavenge free radicals. Two in vitro methods, i.e. oxidation of â-carotene in an emulsion system and DPPH (1,1-Diphenyl-2-picrylhydrazyl) radical scavenging assay, were applied. In addition, a review of in vivo studies that investigate the effectiveness of food flavonoids in reducing oxidative damage in human body was done and their results were analyzed and compared to in vitro results obtained in our laboratory. Although all tested flavonoids except apigenin showed strong antioxidant and antiradical properties in vitro, these findings can not be completely confirmed from the reviewed in vivo human studies since those results are sometimes contradictoryand inconsistent.
Keywords:phenolics, flavonoids, antioxidant activity, antiradical activity
Publication status:Published
Publication version:Version of Record
Year of publishing:2010
Number of pages:str. 263-271
Numbering:Letn. 57, št. 2
PID:20.500.12556/DKUM-52299 New window
ISSN:1318-0207
UDC:66
ISSN on article:1318-0207
COBISS.SI-ID:14214678 New window
NUK URN:URN:SI:UM:DK:MPKVRL2W
Publication date in DKUM:10.07.2015
Views:1343
Downloads:76
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Categories:Misc.
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Record is a part of a journal

Title:Acta Chimica Slovenica
Shortened title:Acta Chim. Slov.
Publisher:Slovensko kemijsko društvo
ISSN:1318-0207
COBISS.SI-ID:14086149 New window

Document is financed by a project

Funder:ARRS - Slovenian Research Agency
Project number:P2-0046
Name:Separacijski procesi in produktna tehnika

Licences

License:CC BY 4.0, Creative Commons Attribution 4.0 International
Link:http://creativecommons.org/licenses/by/4.0/
Description:This is the standard Creative Commons license that gives others maximum freedom to do what they want with the work as long as they credit the author.
Licensing start date:10.07.2015

Secondary language

Language:Slovenian
Abstract:Epidemiološke študije kažejo, da ima konzumiranje živil bogatih s polifenoli, predvsem s flavonoidi, preventivni vpliv na koronarno srčno bolezen. Flavonoidi naj bi vplivali na zmanjšanje oksidacije LDL holesterola in vitro. Namen naše študije je bil določiti antioksidativno aktivnost in radikalsko reaktivnost flavonoidov kot so miricetin, kvercetin, rutin, luteolin, apigenin, kempferol, katehin, epikatehin in epikatehin galat ter preučiti vpliv kemijske strukture in interakcij na sposobnost inhibicije oksidacije in vezavo prostih radikalov. Uporabili smo dve in vitro metodi: oksidacijo β-karotena v emulziji in DPPH (1,1-Diphenyl-2-picrylhydrazyl) metodo. V zaključku smo podali pregled ter analizo in vivo študij antioksidativne učinkovitosti flavonoidov v človeškem telesu ter jih primerjali z rezultati naših in vitro raziskav. Čeprav so vsi testirani flavonoidi razen apigenina pokazali močne antioksidativne in antiradikalske lastnosti in vitro, se ti rezultati ne ujemajo popolnoma z in vivo študijami, ki so včasih protislovne in nedosledne.
Keywords:fenoli, flavonoidi, antioksidantske aktivnosti, antiradicalne aktivnosti


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