| | SLO | ENG | Piškotki in zasebnost

Večja pisava | Manjša pisava

Izpis gradiva Pomoč

Naslov:ATP regulates sodium channel kinetics in pancreatic islet beta cells
Avtorji:ID Zou, Na (Avtor)
ID Rupnik, Marjan (Avtor)
Datoteke:URL http://link.springer.com/content/pdf/10.1007%2Fs00232-012-9506-7.pdf
 
Jezik:Angleški jezik
Vrsta gradiva:Delo ni kategorizirano
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:MF - Medicinska fakulteta
Opis:Pancreatic beta cells act as glucose sensors, in which intracellular ATP ([ATP](i)) are altered with glucose concentration change. The characterization of voltage-gated sodium channels under different [ATP](i) remains unclear. Here, we demonstrated that increasing [ATP](i) within a certain range of concentrations (2-8 mM) significantly enhanced the voltage-gated sodium channel currents, compared with 2 mM cytosolic ATP. This enhancement was attenuated by even high intracellular ATP (12 mM). Furthermore, elevated ATP modulated the sodium channel kinetics in a dose-dependent manner. Increased [ATP](i) shifted both the current-voltage curve and the voltage-dependent inactivation curve of sodium channel to the right. Finally, the sodium channel recovery from inactivation was significantly faster when the intracellular ATP level was increased, especially in 8 mM [ATP](i), which is an attainable concentration by the high glucose stimulation. In summary, our data suggested that elevated cytosolic ATP enhanced the activity of Na(+) channels, which may play essential roles in modulating cell excitability and insulin release when blood glucose concentration increases.
Ključne besede:Langerhansovi otočki, trebušna slinavka
Leto izida:2013
Št. strani:str. 101-107
Številčenje:Vol. 246, iss. 2
PID:20.500.12556/DKUM-50505 Novo okno
UDK:612.349.7
COBISS.SI-ID:512288568 Novo okno
ISSN pri članku:0022-2631
NUK URN:URN:SI:UM:DK:8YJ0HDMY
Datum objave v DKUM:10.07.2015
Število ogledov:2102
Število prenosov:219
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
Področja:Ostalo
:
Kopiraj citat
  
Skupna ocena:(0 glasov)
Vaša ocena:Ocenjevanje je dovoljeno samo prijavljenim uporabnikom.
Objavi na:Bookmark and Share


Postavite miškin kazalec na naslov za izpis povzetka. Klik na naslov izpiše podrobnosti ali sproži prenos.

Gradivo je del revije

Naslov:The journal of membrane biology
Skrajšan naslov:J. membr. biol.
Založnik:Springer
ISSN:0022-2631
COBISS.SI-ID:25763840 Novo okno

Komentarji

Dodaj komentar

Za komentiranje se morate prijaviti.

Komentarji (0)
0 - 0 / 0
 
Ni komentarjev!

Nazaj
Logotipi partnerjev Univerza v Mariboru Univerza v Ljubljani Univerza na Primorskem Univerza v Novi Gorici