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Naslov:Selective regulation of protein activity by complex Ca[sup]2+ oscillations : a theoretical study
Avtorji:ID Knoke, Beate (Avtor)
ID Marhl, Marko (Avtor)
ID Schuster, Stefan (Avtor)
Datoteke:URL http://dx.doi.org/10.1007/978-0-8176-4558-8_2
 
Jezik:Angleški jezik
Vrsta gradiva:Znanstveno delo
Tipologija:1.16 - Samostojni znanstveni sestavek ali poglavje v monografski publikaciji
Organizacija:FNM - Fakulteta za naravoslovje in matematiko
Opis:Calcium oscillations play an important role in intracellular signal transduction. As a second messenger, ▫$Ca^{2+}$▫ represents a link between several input signals and several target processes in the cell. Whereas the frequency of simple ▫$Ca^{2+}$▫ oscillations enables a selective activation of a specific protein and herewith a particular process, the question arises of how at the same time two or more classes of proteins can be specifically regulated. The question is general and concerns the problem of how one second messenger can transmit more than one signal simultaneously (bow-tie structure of signalling). To investigate whether a complex ▫$Ca^{2+}$▫ signal like bursting, a succession of low-peak and high-peak oscillatory phases, could selectively activate different proteins, several bursting patterns with simplified square pulses were applied in a theoretical model. The results indicate that bursting ▫$Ca^{2+}$▫ oscillations allow a differential regulation of two different calcium-binding proteins, and hence, perform the desired function.
Ključne besede:biophysics, calcium oscillations, cellular dynamics, mathematical models, signalling, bow-tie structures, bursting, decoding
Leto izida:2007
PID:20.500.12556/DKUM-35894 Novo okno
UDK:539.19:577
COBISS.SI-ID:15940360 Novo okno
NUK URN:URN:SI:UM:DK:Q4GWPL58
Datum objave v DKUM:07.06.2012
Število ogledov:1929
Število prenosov:35
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
Področja:Ostalo
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Jezik:Slovenski jezik
Ključne besede:biofizika, kalcijeve oscilacije, celična dinamika, matematični modeli


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