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Naslov:Lipid layers on polyelectrolyte multilayer supports
Avtorji:ID Fischlechner, Martin (Avtor)
ID Zaulig, Markus (Avtor)
ID Meyer, Stefan (Avtor)
ID Estrela-Lopis, Irina (Avtor)
ID Cuéllar, Luis (Avtor)
ID Irigoyen, Joseba (Avtor)
ID Pescador, Paula (Avtor)
ID Brumen, Milan (Avtor)
ID Messner, Paul (Avtor)
ID Moya, Sergio (Avtor)
ID Donath, Edwin (Avtor)
Datoteke:URL http://dx.doi.org/10.1039/b805754k
 
Jezik:Angleški jezik
Vrsta gradiva:Neznano
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:FNM - Fakulteta za naravoslovje in matematiko
Opis:The mechanism of formation of supported lipid layers from phosphatidylcholine and phosphatidylserine vesicles in solution on polyelectrolyte multilayers was studied by a variety of experimental techniques. The interaction of zwitterionic and acidic lipid vesicles, as well as their mixtures, with polyelectrolyte supports was followed in real time by micro-gravimetry. The fabricated lipid-polyelectrolyte composite structures on top of multilayer coated colloidal particles were characterized by flow cytometry and imaging techniques. Lipid diffusion over the macroscopic scale was quantified by fluorescence recovery after photobleaching, and the diffusion was related to layer connectivity. The phospholipid-polyelectrolyte binding mechanism was investigated by infrared spectroscopy. A strong interaction of polyelectrolyte primary amino groups with phosphate and carboxyl groups of the phospholipids, leading to dehydration, was observed. Long-range electrostatic attraction was proven to be essential for vesicle spreading and rupture. Fusion of lipid patches into a homogeneous bilayer required lateral mobility of the lipids on the polyelectrolyte support. The binding of amino groups to the phosphate group of the zwitterionic lipids was too weak to induce vesicle spreading, but sufficient for strong adsorption. Only the mixture of phosphatidylcholine and phosphatidylserine resulted in the spontaneous formation of bilayers on polyelectrolyte multilayers. The adsorption of phospholipids onto multilayers displaying quarternary ammonium polymers produced a novel 3D lipid polyelectrolyte structure on colloidal particles.
Ključne besede:biophysics, lipids, lipid layers, electrolytes, multilayer supports
Leto izida:2008
PID:20.500.12556/DKUM-35744 Novo okno
UDK:577.115:53.082.75
COBISS.SI-ID:16347912 Novo okno
ISSN pri članku:1744-683X
NUK URN:URN:SI:UM:DK:MSZNVRRZ
Datum objave v DKUM:07.06.2012
Število ogledov:1818
Število prenosov:73
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
Področja:Ostalo
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Skupna ocena:(0 glasov)
Vaša ocena:Ocenjevanje je dovoljeno samo prijavljenim uporabnikom.
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Gradivo je del revije

Naslov:Soft matter
Založnik:Royal Society of Chemistry
ISSN:1744-683X
COBISS.SI-ID:19616551 Novo okno

Sekundarni jezik

Jezik:Angleški jezik
Ključne besede:biofizika, lipidi, lipidne plasti, elektroliti


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