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Title:Spatio-temporal modelling explains the effect of reduced plasma membrane Ca[sup]2+[/sup] efflux on intracellular Ca[sup]2+[/sup] oscillations in hepatocytes
Authors:ID Marhl, Marko (Author)
ID Gosak, Marko (Author)
ID Perc, Matjaž (Author)
ID Dixon, C. Jane (Author)
ID Green, Anne K. (Author)
Files:URL http://dx.doi.org/10.1016/j.jtbi.2007.11.006
Work type:Unknown
Typology:1.01 - Original Scientific Article
Organization:FNM - Faculty of Natural Sciences and Mathematics
Abstract:In many non-excitable eukaryotic cells, including hepatocytes, ▫$Ca^{2+}$▫ oscillations play a key role in intra- and intercellular signalling, thus regulating many cellular processes from fertilisation to death. Therefore, understanding the mechanisms underlying these oscillations, and consequently understanding how they may be regulated, is of great interest. In this paper, we study the influence of reduced ▫$Ca^{2+}$▫ plasma membrane efflux on ▫$Ca^{2+}$▫ oscillations in hepatocytes. Our previous experiments with carboxyeosin show that a reduced plasma membrane ▫$Ca^{2+}$▫ efflux increases the frequency of ▫$Ca^{2+}$▫ oscillations, but does not affect the duration of individual transients. This phenomenon can be best explained by taking into account not only the temporal,but also the spatial dynamics underlying the generation of ▫$Ca^{2+}$▫ oscillations in the cell. Here we divide the cell into a grid of elements and treat the ▫$Ca^{2+}$▫ dynamics as a spatio-temporal phenomenon. By converting an existing temporal model into a spatio-temporal one, we obtain theoretical predictions that are in much better agreement with the experimental observations.
Keywords:cellular signalling, calcium oscillations, intracellular oscilations, spatio-temporal dynamics, hepatocytes, stochastic simulations
Year of publishing:2008
PID:20.500.12556/DKUM-35725 New window
ISSN on article:0022-5193
COBISS.SI-ID:16014344 New window
Publication date in DKUM:07.06.2012
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Record is a part of a journal

Title:Journal of theoretical biology
Shortened title:J. theor. biol.
Publisher:Academic Press.
COBISS.SI-ID:25806848 New window

Secondary language

Keywords:celično signaliziranje, kalcijeve oscilacije, celične oscilacije, prostorsko-časovna dinamika, hepatociti, stohastične simulacije


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