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Naslov:Establishing the stochastic nature of intracellular calcium oscillations from experimental data
Avtorji:Perc, Matjaž (Avtor)
Green, Anne K. (Avtor)
Dixon, C. Jane (Avtor)
Marhl, Marko (Avtor)
Datoteke:URL http://dx.doi.org/10.1016/j.bpc.2007.10.002
 
Jezik:Angleški jezik
Vrsta gradiva:Neznano ()
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:FNM - Fakulteta za naravoslovje in matematiko
Opis:Calcium has been established as a key messenger in both intra- and intercellular signaling. Experimentally observed intracellular calcium responses to different agonists show a variety of behaviors from simple spiking to complex oscillatory regimes. Here we study typical experimental traces of calcium oscillations in hepatocytes obtained in response to phenylephrine and ATP. The traces were analyzed with methods of nonlinear time series analysis in order to determine the stochastic/deterministic nature of the intracellular calcium oscillations. Despite the fact that the oscillations appear, visually, to be deterministic yet perturbed by noise, our analyses provide strong evidence that the measured calcium traces in hepatocytes are prevalently of stochastic nature. In particular, bursting calcium oscillations are temporally correlated Gaussian series distorted by a monotonic, instantaneous, time-independent function, whilst the spiking behavior appears to have a dynamical nonlinear component whereby the overall determinism level is still low. The biological importance of this finding is discussed in relation to the mechanisms incorporated in mathematical models as well as the role of stochasticity and determinism at cellular and tissue levels which resemble typical statistical and thermodynamic effects in physics.
Ključne besede:dynamic systems, stochastic processes, cellular signaling, calcium oscillations, time series analyses, noise, temporal correlation
Leto izida:2008
UDK:539.2:519.216
COBISS_ID:15744008 Povezava se odpre v novem oknu
ISSN pri članku:0301-4622
NUK URN:URN:SI:UM:DK:8TFS75PU
Število ogledov:970
Število prenosov:63
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
Področja:Ostalo
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Gradivo je del revije

Naslov:Biophysical chemistry
Založnik:North-Holland
ISSN:0301-4622
COBISS.SI-ID:94511 Novo okno

Sekundarni jezik

Jezik:Angleški jezik
Ključne besede:dinamični sistemi, stohastični procesi, celični sistemi, kalcijeve oscilacije, analize časovnih zaporedij, hrup, časovne korelacije


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