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Title:Establishing the stochastic nature of intracellular calcium oscillations from experimental data
Authors:Perc, Matjaž (Author)
Green, Anne K. (Author)
Dixon, C. Jane (Author)
Marhl, Marko (Author)
Files:URL http://dx.doi.org/10.1016/j.bpc.2007.10.002
Work type:Unknown ()
Typology:1.01 - Original Scientific Article
Organization:FNM - Faculty of Natural Sciences and Mathematics
Abstract:Calcium has been established as a key messenger in both intra- and intercellular signaling. Experimentally observed intracellular calcium responses to different agonists show a variety of behaviors from simple spiking to complex oscillatory regimes. Here we study typical experimental traces of calcium oscillations in hepatocytes obtained in response to phenylephrine and ATP. The traces were analyzed with methods of nonlinear time series analysis in order to determine the stochastic/deterministic nature of the intracellular calcium oscillations. Despite the fact that the oscillations appear, visually, to be deterministic yet perturbed by noise, our analyses provide strong evidence that the measured calcium traces in hepatocytes are prevalently of stochastic nature. In particular, bursting calcium oscillations are temporally correlated Gaussian series distorted by a monotonic, instantaneous, time-independent function, whilst the spiking behavior appears to have a dynamical nonlinear component whereby the overall determinism level is still low. The biological importance of this finding is discussed in relation to the mechanisms incorporated in mathematical models as well as the role of stochasticity and determinism at cellular and tissue levels which resemble typical statistical and thermodynamic effects in physics.
Keywords:dynamic systems, stochastic processes, cellular signaling, calcium oscillations, time series analyses, noise, temporal correlation
Year of publishing:2008
ISSN on article:0301-4622
COBISS_ID:15744008 Link is opened in a new window
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Record is a part of a journal

Title:Biophysical chemistry
COBISS.SI-ID:94511 New window

Secondary language

Keywords:dinamični sistemi, stohastični procesi, celični sistemi, kalcijeve oscilacije, analize časovnih zaporedij, hrup, časovne korelacije


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