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Izpis gradiva

Naslov:Exocytosis of insulin in vivo maturation of mouse endocrine pancreas
Avtorji:Rozzo, Aldo (Avtor)
Meneghel-Rozzo, Tiziana (Avtor)
Lipovšek Delakorda, Saška (Avtor)
Yang, Shi-Bing (Avtor)
Rupnik, Marjan (Avtor)
Datoteke:URL http://dx.doi.org/10.1111/j.1749-6632.2008.04003.x
 
Jezik:Angleški jezik
Vrsta gradiva:Neznano ()
Tipologija:1.08 - Objavljeni znanstveni prispevek na konferenci
Organizacija:FNM - Fakulteta za naravoslovje in matematiko
Opis:The aim of this study was to define when an insulin-positive cell becomes functional in vivo and starts to exocytose insulin in a regulated nutrient-dependent manner. Insulin-positive cells appear in embryonic life (midgestation) and complete their maturation, presumably around birth. In order to work with embryonic and newborn endocrine pancreas, we used organotypic slices. The mouse embryonic pancreas slices show high basal insulin release that is not further elevated by high glucose levels. Despite the presence of functional voltage-activated ion channels, the cells are not electrically active in the presence of secretagogues. At birth, the high basalinsulin release drops and, after postnatal day 2, the insulin-positive cells show both adult-like bursting electrical activity and hormone release induced by high glucose levels. These properties allowed us to define them as beta cells. Despite the apparent stability of the transcription factor profile reported in insulin-positive cells during late-embryonic life, functional beta cells appear only 2 days after birth.
Ključne besede:cell biology, insulin release, embrios, newborn, beta-cell maturation, developing pancreas
Leto izida:2009
UDK:577
COBISS_ID:16900616 Novo okno
ISSN pri članku:0077-8923
NUK URN:URN:SI:UM:DK:VR7EQCXI
Število ogledov:957
Število prenosov:19
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Gradivo je del revije

Naslov:Annals of the New York Academy of Sciences
Skrajšan naslov:Ann. N.Y. Acad. Sci.
Založnik:New York Academy of Sciences
ISSN:0077-8923
COBISS.SI-ID:24967680 Novo okno

Sekundarni jezik

Jezik:Angleški jezik
Ključne besede:biologija celice, sprostitev inzulina, embrio


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