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Naslov:Calcium dependencies of regulated exocytosis in different endocrine cells
Avtorji:Dolenšek, Jurij (Avtor)
Skelin, Maša (Avtor)
Rupnik, Marjan (Avtor)
Datoteke:URL http://www.biomed.cas.cz/physiolres/pdf/60%20Suppl%201/60_S29.pdf
 
Jezik:Angleški jezik
Vrsta gradiva:Drugo (9)
Tipologija:1.02 - Pregledni znanstveni članek
Organizacija:MF - Medicinska fakulteta
Opis:Exocytotic machinery in neuronal and endocrine tissues is sensitive to changesin intracellular Ca2+ concentration. Endocrine cell models, that are most frequently used to study the mechanisms of regulated exocytosis, are pancreatic beta cells, adrenal chromaffin cells and pituitary cells. To reliably study the Ca2+ sensitivity in endocrine cells, accurate and fast determination of Ca2+ dependence in each tested cell is required. With slow photo-release it is possible to induce ramp-like increase in intracellular Ca2+ concentration ([Ca2+]i) that leads to a robust exocytotic activity. Slow increases in the [Ca2+]i revealed exocytotic phases with different Ca2+ sensitivities that have been largely masked in step-like flash photo-release experiments. Strikingly, in the cells of the three described model endocrine tissues (beta, chromaffin and melanotroph cells), distinct Ca2+ sensitivity ćclassesć of secretory vesicles have been observed: a highly Ca2+-sensitive, amedium Ca2+-sensitive and a low Ca2+- sensitive kinetic phase of secretory vesicle exocytosis. We discuss that a physiological modulation of a cellular activity, e.g. by activating cAMP/PKA transduction pathway, can switch the secretory vesicles between Ca2+ sensitivity classes. This significantly alterslate steps in the secretory release of hormones even without utilizationof an additional Ca2+ sensor protein.
Ključne besede:Calcium sensitivity, Exocytosis, Insulin-secreting cells, Chromaffin cells, Melanotrophs
Leto izida:2011
UDK:576.32/.36
COBISS_ID:512147512 Novo okno
ISSN pri članku:0862-8408
NUK URN:URN:SI:UM:DK:RKH90VWC
Število ogledov:1322
Število prenosov:44
Metapodatki:XML RDF-CHPDL DC-XML DC-RDF
Področja:Ostalo
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Gradivo je del revije

Naslov:Physiological research
Skrajšan naslov:Physiol. res.
Založnik:Academia
ISSN:0862-8408
COBISS.SI-ID:1251604 Novo okno

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