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Title:Synthesis and use of organic biodegradable aerogels as drug carriers
Authors:ID Veronovski, Anja (Author)
ID Novak, Zoran (Author)
ID Knez, Željko (Author)
Files:URL http://www.ingentaconnect.com/content/vsp/bsp/2012/00000023/00000007/art00003
 
Language:English
Work type:Unknown
Typology:1.01 - Original Scientific Article
Organization:FKKT - Faculty of Chemistry and Chemical Engineering
Abstract:Aerogels of natural polysaccharides possess both biocharacteristics of polysaccharides, such as good biological compatibility and cell or enzyme-controlled degradability, and aerogel characteristics, such as very high porosity and specific surface areas that makes them highly attractive in drug delivery. Biodegradable alginate aerogels were synthesized via a sol-gel process. In the present work two methods of ionic cross-linking were used to prepare alginate hydrogels as monoliths and spheres, which can be further easily converted to high surface area aerogels. The aerogels obtained were further used as drug carriers. We investigated the effect of process parameters, such as starting concentration and viscosity of alginate solution, on synthesis products and on model drug (nicotinic acid) release. The results indicate that by using the internal setting cross-linking method for obtaining monolithic aerogels nicotinic acid was released in a more controlled manner. The aerogels thus obtained also exhibited smaller volume shrinkage than the ones described in other publications. However, with increasing alginate concentration in both types of synthesis more compact and cross-linked aerogels were formed.
Keywords:organic biodegradable gels, natural polysaccharides, aerogels, drug cariers
Year of publishing:2012
PID:20.500.12556/DKUM-27254 New window
UDC:66
ISSN on article:0920-5063
COBISS.SI-ID:15819286 New window
NUK URN:URN:SI:UM:DK:RQXVVXQY
Publication date in DKUM:01.06.2012
Views:2435
Downloads:110
Metadata:XML DC-XML DC-RDF
Categories:Misc.
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Record is a part of a journal

Title:Journal of biomaterials science
Shortened title:J. biomater. sci., Polym. ed.
Publisher:VSP
ISSN:0920-5063
COBISS.SI-ID:705301 New window

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