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Naslov:Response of monocyte-derived dendritic cells to rapidly solidified nickel-titanium ribbons with shape memory properties
Avtorji:Tomić, Sergej (Avtor)
Rudolf, Rebeka (Avtor)
Brunčko, Mihael (Avtor)
Anžel, Ivan (Avtor)
Savić, V. (Avtor)
Čolić, Miodrag (Avtor)
Datoteke:.pdf European_Cells_and_Materials_2012_Tomic_et_al._Response_of_monocyte-derived_dendritic_cells_to_rapidly_solidified_nickel-titanium_ribbon.pdf (1,35 MB)
MD5: 46D6B99513E650ADE5A0C66E33163A24
 
URL http://www.ecmjournal.org/journal/papers/vol023/vol023a05.php
 
Jezik:Angleški jezik
Vrsta gradiva:Znanstveno delo (r2)
Tipologija:1.01 - Izvirni znanstveni članek
Organizacija:FS - Fakulteta za strojništvo
Opis:Ni-Ti Shape Memory Alloys (SMAs) have attracted considerable attention as biomaterials for medical devices. However, the biocompatibility of Ni-Ti SMAs is often unsatisfactory due to their poor surface structure. Here we prepared Rapidly Solidified (RS) Ni-Ti SMA ribbons by melt-spinning and their surface was characterised by Augerelectron spectroscopy, X-ray photoelectron spectrometry and scanning electron microscopy. The biocompatibility of the produced ribbons and their immunomodulatory properties were studied on human monocyte-derived dendritic cells (MoDCs). We showed that melt-spinning of Ni-Ti SMAs can form a thin homogenous oxide layer, which improves their corrosion resistance and subsequent toxicity to MoDCs. Ni-Ti RS ribbons stimulated the maturation of MoDCs, as detected by changes in the cells' morphology and increased expression of HLA-DR, CD86, CD40 and CD83 molecules. However, Ni-Ti RS ribbons enhanced the tolerogenic properties of immature MoDCs, which produced higher levels of IL-10 and IL-27, driving the differentiation of IL-10- and TGF-β-producing CD4+T cells. On the other hand, in the presence of lipopolysaccharide, an important pro-inflammatory biomolecule, Ni-Ti RS ribbons enhanced the allostimulatory and Th1 polarising capacity of MoDCs, whereas the production of Th2 and Th17 cytokines was down-regulated. In conclusion, Ni-Ti RS ribbons possess substantial immunomodulatory properties on MoDCs. These findings might be clinically relevant, because implanted Ni-Ti SMA devices can induce both desired and adverse effects on the immune system, depending on the microenvironmental stimuli.
Ključne besede:nickel-titanium alloy, biocompatibility, cytokines, immunomodulation, monocyte-derived dendritic cells
Leto izida:2012
Št. strani:str. 58-80
Številčenje:Letn. 23
ISSN:1473-2262
UDK:669:61
COBISS_ID:15705366 Novo okno
DOI:10.22203/eCM.v023a05 Novo okno
ISSN pri članku:1473-2262
NUK URN:URN:SI:UM:DK:PQFJBRAW
Število ogledov:1188
Število prenosov:271
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Gradivo je del revije

Naslov:European Cells & Materials
Skrajšan naslov:Eur. Cells Mater.
Založnik:AO Research Institute Davos
ISSN:1473-2262
COBISS.SI-ID:4545306 Novo okno

Sekundarni jezik

Jezik:Slovenski jezik
Ključne besede:nikelj-titanova zlitina, biokompatibilnost, citokini, imunomodulacija, monocitne dendritične celice


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