| Naslov: | PolyHIPE supports in batch and flow-through Suzuki cross-coupling reactions |
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| Avtorji: | ID Brown, Jane F. (Avtor)
ID Krajnc, Peter (Avtor)
ID Cameron, Neil R. (Avtor) |
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| Datoteke: |  http://dx.doi.org/10.1021/ie048843c
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| Jezik: | Angleški jezik |
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| Vrsta gradiva: | Neznano |
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| Tipologija: | 1.01 - Izvirni znanstveni članek |
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| Organizacija: | FKKT - Fakulteta za kemijo in kemijsko tehnologijo
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| Opis: | As part of ongoing research efforts to discover alternative support materials to polymer beads for use in polymer-supported synthesis, particularly under flow-through conditions, this work involves the synthesis of PolyHIPE (High Internal Phase Emulsion) polymer monoliths. PolyHIPEs containing high loadings of chloromethyl groups were efficiently prepared by the direct copolymerization of 4-vinylbenzyl chloride and divinylbenzene monomers. The 'Merrifield' PolyHIPE proved to be an excellent support for batch and flow-through Suzuki cross-coupling reactions. A remarkably high yield of pure biaryl product was obtained using the PolyHIPE support in cubic form and utilizing an electron-rich boronic acid. In comparison to polymer beads, this material was found to be a much more efficient support in both batch and continuous flow modes. PolyHIPE converted a greater amount of chloromethyl groups into biaryl product under identical reaction conditions. It is suggested that the absence of channelling with PolyHIPE monoliths gives better performance under flow-through conditions than permanently porous beads. |
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| Ključne besede: | polymer supports, polymer monoliths, emulsion polymerisation, solid-phase synthesis, cross-coupling reactions |
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| Leto izida: | 2005 |
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| PID: | 20.500.12556/DKUM-27012  |
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| UDK: | 547:678 |
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| COBISS.SI-ID: | 9473558 |
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| ISSN pri članku: | 0888-5885 |
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| NUK URN: | URN:SI:UM:DK:NQHRBJCC |
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| Datum objave v DKUM: | 01.06.2012 |
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| Število ogledov: | 2404 |
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| Število prenosov: | 105 |
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| Metapodatki: |    |
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| Področja: | Ostalo
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