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Title:OPTIMIRANJE TEHNOLOŠKEGA POSTOPKA IZDELAVE TABLET ZA ZDRAVLJENJE PLJUČNE TUBERKULOZE
Authors:ID Ilič, Sandra (Author)
ID Škerget, Mojca (Mentor) More about this mentor... New window
ID Knez, Željko (Comentor)
Files:.pdf VS_Ilic_Sandra_2009.pdf (6,34 MB)
MD5: 30DA3AEC51D2A774B312372C4E120372
PID: 20.500.12556/dkum/de1f5793-8e47-4e45-90a0-e14ae3c587c5
 
Language:Slovenian
Work type:Undergraduate thesis
Organization:FKKT - Faculty of Chemistry and Chemical Engineering
Abstract:Predmet raziskovanja diplomske naloge je optimiranje tehnološkega postopka izdelave tablet za zdravljenje pljučne tuberkuloze v fazi granuliranja, s katerim želimo doseči v tehnološkem postopku predpisane meritve trdnosti in razpadnosti tablet v fazi tabletiranja. Začeli smo tako, da smo v fazi granuliranja v izdelek vgradili 12 kg purificirane vode pri 80% hitrosti vbrizgavanja granulirne tekočine. S tem postopkom smo v fazi tabletiranja izdelali tablete, ki so dajale neustrezno trdnost in zadovoljivo razpadnost. Nadaljevali smo z vgradnjo 13 kg purificirane vode pri enaki hitrosti vbrizgavanja granulirne tekočine, vendar smo na ta način izdelali tablete, ki so dajale ustrezno trdnost tablet in neustrezen, daljši čas razpadnosti tablet. V nadaljevanju smo spremljali lastnosti granulata pri vgradnji 13 kg purificirane vode pri 100% hitrosti vbrizgavanja granulirne tekočine, ki pa je v primerjavi s predhodnimi poizkusi dajal najboljše rezultate. Poizkusi so to tezo potrdili. Glede na rezultate postopkov izdelave smo predpostavili maksimalen čas trajanja mehanske operacije in maksimalen navor mešala v fazi granuliranja. Maksimalnih doseženih mehanskih parametrov pri postopku izdelave zdravila ne smemo prekoračiti. Nato smo želeli ugotoviti vpliv časa mešanja suhega granulata in pomožnih snovi pri pripravi zmesi za tabletiranje na trdnost in razpadnost tablet. Ugotovitve so pokazale, da čas homogenizacije v temu namenjenem mešalniku nima nikakršnega vpliva na trdnost in razpadnost tablet. Vpliv nastavitev tabletirnega stroja na kakovost tablet smo želeli dokazati tako, da smo nastavitve na tabletirnem stroju spreminjali in tako spremljali karakteristične parametre tablet. Rezultati so nam pokazali, da z večanjem sile stiskanja ne dosežemo višje trdnosti tablet in tako tudi predpisanega časa razpadnosti tablet. Po opravljeni raziskavi smo pridobljene rezultate prikazali tabelarično, ki nam bodo v prihodnje v pomoč pri izdelavi tega izdelka.
Keywords:mehanski postopki, homogeniziranje, granuliranje, tabletiranje, trdnost tablet, razpadnost tablet
Place of publishing:Maribor
Publisher:[S. Ilič]
Year of publishing:2009
PID:20.500.12556/DKUM-11086 New window
UDC:[66.022.5:539.215]:615.453.5(043.2)
COBISS.SI-ID:13326102 New window
NUK URN:URN:SI:UM:DK:B338Y7X4
Publication date in DKUM:22.12.2009
Views:4568
Downloads:969
Metadata:XML RDF-CHPDL DC-XML DC-RDF
Categories:KTFMB - FKKT
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Secondary language

Language:English
Title:PROCESS OPTIMIZATION OF TABLETS PREPARATION FOR TREATMENT OF PULMONRY TUBERCULOSIS
Abstract:The scope of this dissertation is the optimisation of granulation stage of the technological procedure for production of tablets, used for the medical treatment of pulmonary tuberculosis. The aim of this optimisation was to achieve the set requirements for hardness and disintegration of tablets in the tabletting stage. Our first experiment started with adding 12 kg of purificated water into the product in the granulation stage by injecting the granular liquid at 80% of speed. By doing so, we have achieved to produce tablets with corresponding disintegration, but they did not have the required hardness. In next step we added 13 kg of purificated water with the same injection speed of the granular liquid as in first experiment. In this case the tablets had the required hardness, but the disintegration was not within the set limits. Due to this, we have changed the characteristics of granulate by adding 13 kg of purified water with the injection of granular liquid at 100% of speed, which in comparison with previous experiments, gave us the best results. The test has confirmed this thesis. With the results obtained by experiments we were able to determine the maximal duration time of mechanical operation and maximal torque of the stirrer in the granulation stage. Determined maximal mechanical parameters should not be exceeded in the production of drug. Afterwards, we intended to establish how the stirring time, of a dry granulate and excipients in the preparation of tabletting mass, influences the hardness and disintegration of tablets. The results showed that time of homogenization in the stirrer does not affect the hardness and disintegration of tablets. We have also tried to demonstrate how the settings of the tabletting machine are affecting the quality of the product. The results showed that by increasing the pressing force, the tablet hardness is not increased tablet hardness and thus the prescribed time of tablet disintegration is not obtained. Finally, the results obtained in present work are summarized and presented in tabular form, wich offers a support for optimization of tablet production. The table demonstrates the influence of control parameters on the product characteristics in the granulation stage.
Keywords:mechanical procedures, homogenization, granulation, tabletting, hardness of tablets, disintegration of tablets


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