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1.
Practical approaches to the control of milk fermentation with kefir grains
Jožef Ritonja, Andreja Goršek, Darja Pečar, Darius Andriukaitis, Boštjan Polajžer, 2024, samostojni znanstveni sestavek ali poglavje v monografski publikaciji

Opis: In the chapter, milk fermentation for kefir production is studied. The traditional kefir production process based on inoculating kefir grains into milk is considered. The quality and quantity of the produced kefir also depend on the dynamics of the fermentation process. The chapter presents the design and synthesis of the closed-loop control system in which changing the bioreactor’s temperature is used to control the time course of the concentration of dissolved CO2. In the chapter: (1) a nonlinear dynamic mathematical model of the fermentation process, which allows evaluating the influence of the bioreactor’s temperature on the dynamics of the fermentation process, is presented; (2) the design and synthesis of a conventional linear control system with constant parameters are carried out; (3) an adaptive control system that enables the tracking of the courses of the quantities of the fermentation process to the desired reference trajectories without the time-consuming preliminary identification of the parameters of the fermentation process model is developed. The numerical, experimental, and analytic outcomes of the study are presented.
Ključne besede: milk fermentation, batch biorector, mathematical modeling, control system design and synthesis, linear control, model reference adaptive control
Objavljeno v DKUM: 08.01.2026; Ogledov: 0; Prenosov: 2
.pdf Celotno besedilo (5,29 MB)
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2.
Specialized Transmitter for Electromagnetic Compatibility Testing : master's thesis
Erik Marič, 2025, magistrsko delo

Opis: In this thesis, we aimed to design, test, and implement a custom transmitter for electromagnetic compatibility (EMC) testing. After assembling a technological overview of all relevant technologies, we engineered the design of the first prototype. It was a battery powered, manually tunable, communication isolated, compact, portable transmitter that can operate without other control devices in a test setup. The central parameters of improvement were enhanced power output and EMC. The power output needed to be manually tunable and enable constant magnetic field strength over a select set of distances. We had to implement all enhancements to the design while simultaneously improving the electromagnetic compatibility as much as possible. We were focusing on the noise produced by the transmitter itself. According to the test plan, we performed tests in signal quality, output power over distance, and EMC in a GTEM cell. In the first prototype, we did not reach the goals of increasing power output, adding the ability to adjust the output power manually, and increasing electromagnetic compatibility. The amplification stage and output driver stage did not meet the full specifications. The initial stages of the transmitter were fully functional, and we can include them in the next design.
Ključne besede: transmitter, EMC testing, wireless transmission, signal synthesis.
Objavljeno v DKUM: 16.12.2025; Ogledov: 0; Prenosov: 0

3.
Chemo-enzymatic synthesis of viscoelastic pseudopeptidoglycan networks
Philipp Loibner, David Bučak-Gasser, Katharina Schober, Tobias Alexander Steindorfer, Monika Brandtner, Tobias Dorn, Tanja Wrodnigg, Dmytro Neshchadin, Georg Gescheidt-Demner, Matej Bračič, Florian Lackner, Tamilselvan Mohan, Karin Stana-Kleinschek, Rupert Kargl, 2025, izvirni znanstveni članek

Opis: Bacterial peptidoglycans (PGs) are essential targets for antibiotics and immune cells. Chemical methods to reproduce PGs semisynthetically are tedious and wasteful. In this work, we describe a new approach to form pseudo-PGs (PPGs) using the protease papain and custom-made peptides conjugated to a glycan. The kinetics of formation is monitored by rheology and 1H NMR. Viscoelastic gels of controlled strength are formed, depending on the temperature and the number of peptide bridges between the glycan chains. We propose that the new method has a high impact on biomaterials research, since it could be used to deliver peptides, test antibiotic efficacy, or investigate human immune cell response.
Ključne besede: biomaterials, bacterial peptidoglycans (PGs), chemo-enzymatic synthesis
Objavljeno v DKUM: 03.11.2025; Ogledov: 0; Prenosov: 7
.pdf Celotno besedilo (4,32 MB)
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4.
Modular flow synthesis of citric acid-coated superparamagnetic iron oxide nanoparticles : preliminary results
Sabina Vohl, Andreja Nemet, Janja Stergar, 2025, izvirni znanstveni članek

Opis: Superparamagnetic iron oxide nanoparticles (SPIONs) with sizes below 10 nm are biocompatible and non-toxic, making them promising for biomedical applications. To prevent their agglomeration and enhance their functionality, the nanoparticles were coated with citric acid (CA), which modifies the surface charge, improves dispersion stability, and facilitates biomedical use. In this work, a modular flow-through microreactor system was employed to synthesize and coat the nanoparticles in a single, continuous two-step process. The system enables precise control over temperature and mixing, ensuring uniform reaction conditions and minimizing hot spots. The synthesized Fe3O4 nanoparticles exhibited an average crystallite size of ~5 nm (XRD) and particle sizes of 4–6 nm (TEM). FTIR analysis confirmed the successful surface functionalization with CA, while TGA indicated a coating mass fraction of approximately 4–20 wt%, increasing with higher CA concentration. Zeta potential measurements revealed strong colloidal stability, with values around −35 mV at pH 6.5. Among the tested CA concentrations, the sample with a molar ratio of Fe3O4:CA = 1:0.25 exhibited the most favorable properties, including narrow size distribution and improved dispersion stability. These findings demonstrate that the continuous modular flow approach enables the reproducible synthesis of highly stable, sub-10 nm CA-coated SPIONs, offering promising potential for biomedical applications, particularly as magnetic resonance imaging (MRI) contrast agents.
Ključne besede: superparamagnetic iron oxide nanoparticles, citric acid, modular flow microreactor system, continuous synthesis, zeta potential measurements
Objavljeno v DKUM: 03.11.2025; Ogledov: 0; Prenosov: 3
.pdf Celotno besedilo (1,54 MB)

5.
Evolutionary game theory use in healthcare : a synthetic knowledge synthesis
Peter Kokol, Jernej Završnik, Helena Blažun Vošner, Bojan Žlahtič, 2025, pregledni znanstveni članek

Opis: Background: Evolutionary game theory (EGT), originating from Darwinian competition studies, offers a powerful framework for understanding complex healthcare interactions where multiple stakeholders with conflicting interests evolve strategies over time. Unlike traditional game theory, EGT accounts for bounded rationality and strategic evolution through imitation and selection. Aims and objectives: In our study, we use Synthetic Knowledge Synthesis (SKS) that integrates descriptive bibliometrics and bibliometric mapping to systematically analyze the application of EGT in healthcare. The SKS aimed to identify prolific research topics, suitable publishing venues, and productive institutions/countries for collaboration and funding. Data was harvested from the Scopus bibliographic database, encompassing 539 publications from 2000 to June 2025, Results: Production dynamics is revealing an exponential growth in scholarly output since 2019, with peak productivity in 2024. Descriptive bibliometrics showed China as the most prolific country (376 publications), followed by the United States and the United Kingdom. Key institutions are predominantly Chinese, and top journals include PLoS One and Frontiers in Public Health. Funding is primarily from Chinese entities like the National Natural Science Foundation of China. Bibliometric mapping identified five key research themes: game theory in cancer research, evolution game-based simulation of supply management, evolutionary game theory in epidemics, evolutionary games in trustworthy connected public health, and evolutionary games in collaborative governance. Conclusions: Despite EGT’s utility, significant research gaps exist in methodological robustness, data availability, contextual modelling, and interdisciplinary translation. Future research should focus on integrating machine learning, longitudinal data, and explicit ethical frameworks to enhance EGT’s practical application in adaptive, patient-centred healthcare systems
Ključne besede: evolutionary games theory, healthcare, complex healthcare systems, synthetic knowledge synthesis, thematic analysis
Objavljeno v DKUM: 29.10.2025; Ogledov: 0; Prenosov: 4
.pdf Celotno besedilo (587,94 KB)

6.
The use of AI in software engineering : a synthetic knowledge synthesis of the recent research literature
Peter Kokol, 2024, pregledni znanstveni članek

Opis: Artificial intelligence (AI) has witnessed an exponential increase in use in various applications. Recently, the academic community started to research and inject new AI-based approaches to provide solutions to traditional software-engineering problems. However, a comprehensive and holistic understanding of the current status needs to be included. To close the above gap, synthetic knowledge synthesis was used to induce the research landscape of the contemporary research literature on the use of AI in software engineering. The synthesis resulted in 15 research categories and 5 themes—namely, natural language processing in software engineering, use of artificial intelligence in the management of the software development life cycle, use of machine learning in fault/defect prediction and effort estimation, employment of deep learning in intelligent software engineering and code management, and mining software repositories to improve software quality. The most productive country was China (n = 2042), followed by the United States (n = 1193), India (n = 934), Germany (n = 445), and Canada (n = 381). A high percentage (n = 47.4%) of papers were funded, showing the strong interest in this research topic. The convergence of AI and software engineering can significantly reduce the required resources, improve the quality, enhance the user experience, and improve the well-being of software developers.
Ključne besede: software engineering, artificial intelligence, machine learning, synthetic knowledge synthesis, AI
Objavljeno v DKUM: 30.07.2025; Ogledov: 0; Prenosov: 12
.pdf Celotno besedilo (1,39 MB)
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7.
The role of correspondence analysis in medical research
Bojan Žlahtič, Peter Kokol, Helena Blažun Vošner, Jernej Završnik, 2024, drugi znanstveni članki

Opis: Correspondence analysis (CA) is a multivariate statistical and visualization technique. CA is extremely useful in analyzing either two- or multi-way contingency tables, representing some degree of correspondence between columns and rows. The CA results are visualized in easy-to-interpret “bi–plots,” where the proximity of items (values of categorical variables) represents the degree of association between presented items. In other words, items positioned near each other are more associated than those located farther away. Each bi-plot has two dimensions, named during the analysis. The naming of dimensions adds a qualitative aspect to the analysis. Correspondence analysis may support medical professionals in finding answers to many important questions related to health, wellbeing, quality of life, and similar topics in a simpler but more informal way than by using more complex statistical or machine learning approaches. In that way, it can be used for dimension reduction and data simplification, clustering, classification, feature selection, knowledge extraction, visualization of adverse effects, or pattern detection.
Ključne besede: public health, medical research, correspondence analysis, synthetic knowledge synthesis, exploratory data analysis, bibliometric
Objavljeno v DKUM: 30.07.2025; Ogledov: 0; Prenosov: 1
.pdf Celotno besedilo (614,75 KB)
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8.
Machine learning in primary health care : the research landscape
Jernej Završnik, Peter Kokol, Bojan Žlahtič, Helena Blažun Vošner, 2025, pregledni znanstveni članek

Opis: Background: Artificial intelligence and machine learning are playing crucial roles in digital transformation, aiming to improve the efficiency, effectiveness, equity, and responsiveness of primary health systems and their services. Method: Using synthetic knowledge synthesis and bibliometric and thematic analysis triangulation, we identified the most productive and prolific countries, institutions, funding sponsors, source titles, publications productivity trends, and principal research categories and themes. Results: The United States and the United Kingdom were the most productive countries; Plos One and BJM Open were the most prolific journals; and the National Institutes of Health, USA, and the National Natural Science Foundation of China were the most productive funding sponsors. The publication productivity trend is positive and exponential. The main themes are related to natural language processing in clinical decision-making, primary health care optimization focusing on early diagnosis and screening, improving health-based social determinants, and using chatbots to optimize communications with patients and between health professionals. Conclusions: The use of machine learning in primary health care aims to address the significant global burden of so-called “missed diagnostic opportunities” while minimizing possible adverse effects on patients.
Ključne besede: primary health care, machine learning, research landscape, synthetic knowledge synthesis
Objavljeno v DKUM: 24.07.2025; Ogledov: 0; Prenosov: 6
.pdf Celotno besedilo (887,18 KB)

9.
Artificial intelligence and pediatrics : synthetic knowledge synthesis
Jernej Završnik, Peter Kokol, Bojan Žlahtič, Helena Blažun Vošner, 2024, pregledni znanstveni članek

Opis: The first publication on the use of artificial intelligence (AI) in pediatrics dates back to 1984. Since then, research on AI in pediatrics has become much more popular, and the number of publications has largely increased. Consequently, a need for a holistic research landscape enabling researchers and other interested parties to gain insights into the use of AI in pediatrics has arisen. To fill this gap, a novel methodology, synthetic knowledge synthesis (SKS), was applied. Using SKS, we identified the most prolific countries, institutions, source titles, funding agencies, and research themes and the most frequently used AI algorithms and their applications in pediatrics. The corpus was extracted from the Scopus (Elsevier, The Netherlands) bibliographic database and analyzed using VOSViewer, version 1.6.20. Done An exponential growth in the literature was observed in the last decade. The United States, China, and Canada were the most productive countries. Deep learning was the most used machine learning algorithm and classification, and natural language processing was the most popular AI approach. Pneumonia, epilepsy, and asthma were the most targeted pediatric diagnoses, and prediction and clinical decision making were the most frequent applications.
Ključne besede: pediatrics, artificial intelligence, synthetic knowledge synthesis, bibliometrics, machine learning
Objavljeno v DKUM: 01.07.2025; Ogledov: 0; Prenosov: 9
.pdf Celotno besedilo (1,71 MB)
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10.
Software quality: how much does it matter?
Peter Kokol, 2022, pregledni znanstveni članek

Opis: Interconnected computers and software systems have become an indispensable part of people’s lives in the period of digital transformation. Consequently, software quality research is becoming more and more critical. There have been multiple attempts to synthesise knowledge gained in software quality research; however, they were focused mainly on single aspects of software quality and did not structure the knowledge holistically. To fill this gap, we harvested software quality publications indexed in the Scopus bibliographic database. We analysed them using synthetic content analysis which is a triangulation of bibliometrics and content analysis. The search resulted in 15,468 publications. The performance bibliometric analysis showed that the production of research publications relating to software quality is currently following an exponential growth trend and that the software quality research community is growing. The most productive country was the United States, followed by China. The synthetic content analysis revealed that the published knowledge could be structured into six themes, the most important being the themes regarding software quality improvement by enhancing software engineering, advanced software testing and improved defect and fault prediction with machine learning and data mining.
Ključne besede: software engineering, software quality, knowledge synthesis, bibliometrics, synthetic knowledge synthesis
Objavljeno v DKUM: 07.04.2025; Ogledov: 0; Prenosov: 6
.pdf Celotno besedilo (1,74 MB)
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