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1.
Hemodynamic response to high- and low-load resistance exercise in patients with coronary artery disease : a randomized, crossover clinical trial
Tim Kambič, Vedran Hadžić, Mitja Lainščak, 2021, original scientific article

Abstract: Low-load resistance exercise (LL-RE) is recommended as an adjunct therapy to aerobic exercise during cardiac rehabilitation in patients with coronary artery disease. The safety and hemodynamic response to high-load (HL) RE remain unknown. The aim of this study was to evaluate the hemodynamic response during both HL-RE and LL-RE prior to cardiac rehabilitation. Forty-three patients with coronary artery disease and/or percutaneous coronary intervention performed three sets of leg-press exercise using HL-RE (eight repetitions at the intensity of 80% of one repetition maximum (1-RM)) and LL-RE (16 repetitions at the intensity of 40% 1-RM) in a randomized crossover sequence. Heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), and rating of perceived exertion were measured at baseline, after each set of RE and post-exercise. No clinically relevant changes in HR and BP or in patient-reported symptoms were recorded during HL-RE or LL-RE. Compared with baseline, HR and SBP increased during LL-RE (from 66 bpm to 86 bpm, time effect: p < 0.001; from 129 mmHg to 146 mmHg, time effect: p < 0.001) and HL-RE (from 68 bpm to 86 bpm, time effect: p < 0.001; from 130 mmHg to 146 mmHg, time effect: p < 0.001). Compared with HL-RE, the increase in HR was greater after the final set of LL-RE (32% vs. 28%, p = 0.015), without significant differences in SBP and DBP between LL-RE and HL-RE. Rating of perceived exertion was higher after the 1st set of HL-RE compared with LL-RE (median (interquartile range): 6 (5–7) vs. 6 (5–6), p = 0.010). In patients with coronary artery disease, both HL-RE and LL-RE were safe and well-tolerated. Hemodynamic changes were similar and within the physiological response to RE.
Keywords: sport, cardiac rehabilitation, resistance training, blood pressure, heart rate
Published in DKUM: 20.08.2024; Views: 79; Downloads: 5
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2.
Derivation of analytical expressions for fast calculation of resistance spot welding system currents
Robert Brezovnik, Jožef Ritonja, 2024, original scientific article

Abstract: The paper deals with the dynamics of a resistance spot welding system. At the core of this system is a transformer, which is powered on the primary side by a pulse-width modulated inverter and has a full-wave output rectifier on the secondary side that provides a direct welding current. The entire system is nonlinear, due to magnetic hysteresis and electronics. The electronics prevent the current from flowing in all parts of the welding transformer at separate time intervals during the voltage supply period; therefore, not all the parameters affect the dynamic of currents and voltages all the time so the system is also time-variant. To design a high-performance welding system and to predict the maximum possible welding current at a specific load, it is necessary to know the welding and primary currents. The leakage inductances of the system can reduce the maximum welding current significantly at higher frequencies and the same load. There are several methods to determine these currents, each with its drawbacks. Measurements are time-consuming, using professional software is expensive and requires time to learn and free open-source software has many limitations and does not guarantee the correctness of the results. The article presents a new, fourth option—a theoretical derivation of analytical expressions that facilitate straightforward and rapid calculation of the welding and primary currents of the resistance spot welding system with symmetrical secondary branches. The derivation of the mathematical expressions is based on the equivalent circuits that describe the system in different operating states. The results of the numerical simulations confirmed the derived expressions completely.
Keywords: DC–DC converters, pulse width modulation (PWM), welding transformers, center-tapped transformers, full-wave rectifier, resistance spot welding (RSW), leakage inductance, analytical modeling, time-variant system, equivalent circuit
Published in DKUM: 08.08.2024; Views: 73; Downloads: 8
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3.
ǂThe ǂcorrosion resistance of dental Ti6Al4V with differing microstructures in oral environments
Mirjam Bajt Leban, Tadeja Kosec, Matjaž Finšgar, 2023, original scientific article

Abstract: The impact of the microstructural properties of a Ti6Al4V alloy on its electrochemical properties, as well as the effect of the α- and β-phases present within it, is still unclear. With the introduction of new, emerging technologies, such as selective laser melting and post heat treatments, the effect of the microstructure on an alloy's corrosion properties has become increasingly interesting from a scientific perspective. When these alloys are produced through different methods, despite an identical chemical composition they have diverse microstructures, and consequently display varying resistance to corrosion. In the present research study, Ti–6Al–4V alloy specimens produced by three different processes, leading to the formation of three different microstructures were investigated: heat treated specimen fabricated by selective laser melting, wrought and cast specimens. The impact of the microstructure of these alloys when immersed in artificial saliva was studied through the use of various electrochemical techniques, by microscopical examinations, and time-of-flight secondary ion mass spectrometry. Corrosion properties were investigated by the measurement of open circuit potential, linear polarization, and potentiodynamic curve measurements followed by microscopical examinations, and time-of-flight secondary ion mass spectrometry examination was conducted to reveal spatial distribution of alloying species on oxide film. It was found that the difference between specimens containing an α+β microstructure was small and not dependent on the aspect ratio of the β-phase, alloy grain size, and vanadium partitioning coefficient, but rather on the size, shape, and content of this phase.
Keywords: Ti6Al4V, dental alloy, microstructure, corrosion resistance, heat treatment, ToF-SIMS
Published in DKUM: 07.05.2024; Views: 192; Downloads: 9
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4.
Human beta cell functional adaptation and dysfunction in insulin resistance and its reversibility
Maša Skelin, Jan Kopecky, Jurij Dolenšek, Andraž Stožer, 2023, other scientific articles

Abstract: Background: Beta cells play a key role in the pathophysiology of diabetes since their functional adaptation is able to maintain euglycemia in the face of insulin resistance, and beta cell decompensation or dysfunction is a necessary condition for full-blown type 2 diabetes (T2D). The mechanisms behind compensation and decompensation are incompletely understood, especially for human beta cells, and even less is known about influences of chronic kidney disease (CKD) or immunosupressive therapy after transplantation on these processes and the development of posttransplant diabetes. Summary: During compensation, beta cell sensitivity to glucose becomes left-shifted, i.e., their sensitivity to stimulation increases, and this is accompanied by enhanced signals along the stimulus-secretion coupling cascade from membrane depolarization to intracellular calcium and the most distal insulin secretion dynamics. There is currently no clear evidence regarding changes in intercellular coupling during this stage of disease progression. During decompensation, intracellular stimulus-secretion coupling remains enhanced to some extent at low or basal glucose concentrations but seems to become unable to generate effective signals to stimulate insulin secretion at high or otherwise stimulatory glucose concentrations. Additionally, intercellular coupling becomes disrupted, lowering the number of cells that contribute to secretion. During progression of CKD, beta cells also seem to drift from a compensatory left-shift to failure, and immunosupressants can further impair beta cell function following kidney transplantation. Key Messages: Beta cell stimulus-secretion coupling is enhanced in compensated insulin resistance. With worsening insulin resistance, both intra- and intercellular coupling become disrupted. CKD can progressively disrupt beta cell function, but further studies are needed, especially regarding changes in intercellular coupling.
Keywords: human beta cell, functional adaptation, dysfunction, insulin resistance
Published in DKUM: 15.04.2024; Views: 182; Downloads: 16
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6.
Numerical analysis of the racking behaviour of multi-storey timber-framed buildings considering load-bearing function of double-skin façade elements
Miroslav Premrov, Erika Kozem Šilih, 2023, original scientific article

Abstract: The paper presents an innovative approach in the modelling of multi-storey timber-framed buildings, where double-skin façade elements (DSF) are additionally considered as load-bearing wall elements against a horizontal load impact. The mathematical model with a fictive diagonal element developed for timber-framed wall elements with classical oriented strand boards (OSB) or fibre–plaster sheathing boards (FPB) is upgraded for DSF elements. The diameter of the fictive diagonal is determined with either experimental results or numerically obtained results using the time-consuming FEM model with elastic spring elements, which simulates the bonding line between the timber frame and both glazing panes. In the second part of the study, the numerical analysis of a specially selected three-storey timber-framed building was performed using the developed mathematical model with fictive diagonal elements. Two alternative calculations were performed with the DSF elements as non-resisting and racking-resisting wall elements. It was demonstrated on the selected case that the racking resistance (R) of a building can essentially increase up to 35% if DSF elements are considered as resisting wall elements. As a secondary goal of the study, it is also important to point out that by using DSF elements as racking-resisting elements, the distortion in the first floor essentially decreased. It is demonstrated on the selected numerical example that this torsional influence decreased notably (by almost 18%) when the load-bearing DSF elements were used for seismic excitation in the X direction. Therefore, such an approach can open new perspectives in designing multi-storey timber-framed buildings with a more attractive and dynamic floor plan and structure.
Keywords: sustainability, timber, structures, multi-storey, numerical analysis, DSF, racking resistance
Published in DKUM: 19.03.2024; Views: 214; Downloads: 25
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7.
Monocarbonyl Curcumin Analogues as Potent Inhibitors against Human Glutathione Transferase P1-1
Panagiota D. Pantiora, Veronika Furlan, Dimitris Matiadis, Barbara Mavroidi, Fereniki Perperopoulou, Anastassios C. Papageorgiou, Marina Sagnou, Urban Bren, Maria Pelecanou, Nikolaos E. Labrou, 2023, original scientific article

Abstract: The isoenzyme of human glutathione transferase P1-1 (hGSTP1-1) is involved in multi-drug resistance (MDR) mechanisms in numerous cancer cell lines. In the present study, the inhibition potency of two curcuminoids and eleven monocarbonyl curcumin analogues against hGSTP1-1 was investigated. Demethoxycurcumin (Curcumin II) and three of the monocarbonyl curcumin analogues exhibited the highest inhibitory activity towards hGSTP1-1 with IC50 values ranging between 5.45 1.08 and 37.72 1.02 M. Kinetic inhibition studies of the most potent inhibitors demonstrated that they function as non-competitive/mixed-type inhibitors. These compounds were also evaluated for their toxicity against the prostate cancer cells DU-145. Interestingly, the strongest hGSTP1-1 inhibitor, (DM96), exhibited the highest cytotoxicity with an IC50 of 8.60 1.07 M, while the IC50 values of the rest of the compounds ranged between 44.59–48.52 M. Structural analysis employing molecular docking, molecular dynamics (MD) simulations, and binding-free-energy calculations was performed to study the four most potent curcumin analogues as hGSTP1-1 inhibitors. According to the obtained computational results, DM96 exhibited the lowest binding free energy, which is in agreement with the experimental data. All studied curcumin analogues were found to form hydrophobic interactions with the residue Gln52, as well as hydrogen bonds with the nearby residues Gln65 and Asn67. Additional hydrophobic interactions with the residues Phe9 and Val36 as well as – stacking interaction with Phe9 contributed to the superior inhibitory activity of DM96. The van derWaals component through shape complementarity was found to play the most important role in DM96-inhibitory activity. Overall, our results revealed that the monocarbonyl curcumin derivative DM96 acts as a strong hGSTP1-1 inhibitor, exerts high prostate cancer cell cytotoxicity, and may, therefore, be exploited for the suppression and chemosensitization of cancer cells. This study provides new insights into the development of safe and effective GST-targeted cancer chemosensitizers.
Keywords: curcuminoids, curcumin analogues, human glutathione transferase P1-1 (hGSTP1-1), glutathione transferase, enzyme inhibition, multi-drug resistance
Published in DKUM: 12.03.2024; Views: 276; Downloads: 13
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8.
Fracture toughness of HSLA welds made on penstock material
Zdravko Praunseis, 2019, original scientific article

Abstract: The presence of different microstructures along the pre-crack fatigue front has a significant effect on the critical crack tip opening displacement (CTOD). This value is the relevant parameter for the safe servicing of welded structures (penstocks). In the case of specimens with the through-thickness notch partly in the weld metal, partly in the heat-affected zone, and partly in the base material, i.e., using the composite notched specimen, the fracture behaviour significantly depends on the portion of the ductile base material, the size, and the distribution of mismatching factor along the vicinity of the crack front.
Keywords: High Strength low Alloyed Steel, CTOD Fracture Toughness Testing, CTOD-R resistance Curve, Welded joints
Published in DKUM: 22.12.2023; Views: 605; Downloads: 7
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9.
Transient circuit simulation of arc-free current breaking by resistance rise
Dareer Bin Khalid, Michael Rock, Luigi Piegari, 2021, original scientific article

Abstract: There has been intensive research and development in the field of Circuit breakers, whether DC and AC, or low voltage and high voltage. The result of this has led to the production of highly reliable circuit breakers that accompany a built-in arc extinguishing system. However, the purpose of this study is to give the basics for arc-free current breaking with fast interruption of fault currents, e.g., in surge protective devices (SPD) for AC and DC systems, by means of a time-dependent resistor with fast rising resistance. This investigation shall illustrate how the current can be driven almost to zero with a steadily time increasing resistance, and interrupted completely without an electric arc. The basic aim of the conducted transient circuit simulations is to determine suitable time functions for the current or resistance and necessary initial and final resistances. This paper will discuss the "optimisation conditions", a switching time as short as possible, small switch-off overvoltage, and possibly an energy conversion in the resistor as low as possible is set using ATP-EMTP and analytical calculations.
Keywords: current breaking, ATP-EMTP, time-dependent resistance, optimisation, concave functions, convex functions
Published in DKUM: 13.11.2023; Views: 431; Downloads: 4
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10.
Intrinsic fatigue limit and the minimum fatigue crack growth threshold
Mirco Daniel Chapetti, Nenad Gubeljak, Dražan Kozak, 2023, original scientific article

Abstract: In the field of long-life fatigue, predicting fatigue lives and limits for mechanical components is crucial for ensuring reliability and safety. Fracture mechanics tools have enabled the estimation of fatigue lives for components with small cracks or defects. However, when dealing with defects larger than the microstructural characteristic size, estimating the fatigue resistance of a material requires determining the cyclic resistance curve for the defect-free matrix, which depends on knowledge of the material’s intrinsic fatigue limit. This study focuses on the experimental evidence regarding the intrinsic fatigue limit and its correlation with naturally nucleated non-propagating cracks. Fracture mechanics models for small crack propagation are introduced, and their disparities and limitations are analyzed. The concept of intrinsic fatigue limit is then introduced and applied to reanalyze a recent publication. Methods for estimating the intrinsic fatigue limit are explored and applied to experimental results reported in the literature. The need to clarify and accurately predict the intrinsic fatigue limit is highlighted in alloys where the processing generates defects larger than the microstructural size of the matrix, as often observed in materials and components produced using additive manufacturing.In the field of long-life fatigue, predicting fatigue lives and limits for mechanical components is crucial for ensuring reliability and safety. Fracture mechanics tools have enabled the estimation of fatigue lives for components with small cracks or defects. However, when dealing with defects larger than the microstructural characteristic size, estimating the fatigue resistance of a material requires determining the cyclic resistance curve for the defect-free matrix, which depends on knowledge of the material’s intrinsic fatigue limit. This study focuses on the experimental evidence regarding the intrinsic fatigue limit and its correlation with naturally nucleated non-propagating cracks. Fracture mechanics models for small crack propagation are introduced, and their disparities and limitations are analyzed. The concept of intrinsic fatigue limit is then introduced and applied to reanalyze a recent publication. Methods for estimating the intrinsic fatigue limit are explored and applied to experimental results reported in the literature. The need to clarify and accurately predict the intrinsic fatigue limit is highlighted in alloys where the processing generates defects larger than the microstructural size of the matrix, as often observed in materials and components produced using additive manufacturing.
Keywords: intrinsic fatigue limit, microstructural fatigue threshold, material defects, fracture mechanics, intrinsic fatigue resistance
Published in DKUM: 04.09.2023; Views: 382; Downloads: 35
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