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* old and bologna study programme


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Saviour siblings - current overview, dilemmas and possible solutions?
Sandra O. Samardžić, 2019, original scientific article

Abstract: In certain cases, when an already born child is affected with a fatal disease and needs transplantation, the only possible solution could be the creation of saviour sibling. Saviour sibling is a term that refers to a child born through a procedure in which an embryo, created in vitro, is being tested in order to determine whether such an embryo could provide stem cells or tissue for an already born, ill child. If the embryo is both, a matching donor and free of the disease, it could be implanted and after the birth of a child, the umbilical cord stem cells or tissue could be used for treatment of a sick sibling. However, this procedure poses a number of dilemmas. This paper aims to give a brief analysis of these issues, to address some of the main concerns and to provide possible solutions for future regulation of this technique.
Keywords: saviour sibling, right of the child to health, medically assisted reproduction, bone marrow, stem cells
Published in DKUM: 15.01.2021; Views: 870; Downloads: 26
URL Link to file

Influence of temperature on epigenetic changes of common duckweed (Lemna minor L.) in aseptic culture
Stella Prelovšek, 2018, master's thesis

Abstract: Epigenetics is a study of heritable changes in gene expression and function that do not change the DNA sequence itself. One of the commonly described epigenetic modifications is DNA methylation where a methyl group is added to the fifth carbon of the cytosine (Lim & Maher, 2010). This may lead to gene silencing, regulation of gene expression and allows for plant plasticity to changing environment (Verhoeven et al., 2010). Epigenetic variation is often studied in species with asexual reproduction, due to the absence of genetic variation between individuals and because clonal species do not go through a germline and meiosis between generations which epigenetic resetting occurs. Lemna minor, also known as common duckweed, is the smallest flowering macrophyte that consist of modified leaf structures (fronds) and one hanging root. It is known for its rapid asexual reproduction (Ziegler et al., 2015). Daughter fronds are genetically identical to the mother plant and are produced without involvement of male or female germlines. Fast asexual reproduction makes Lemna minor a perfect candidate to study epigenetic effects of de novo gene regulatory evolution. The aim of this project is to screen divergence of environmentally-induced DNA methylation between different experimental treatments over multiple generations. The aim of this project is to screen divergence of temperature-induced DNA methylation between different experimental treatments over multiple generations. Results show that, temperature stress has a strong influence on L. minor growth and reproduction, and induces significant change in the DNA methylation in the CG and CHG methylation context. Temperature-induced DNA methylation was inherited over multiple clonal generation of L. minor in the CHG contexts, although since we did not detect any performance difference the functional consequences of this DNA methylation are unclear. This study contributes to the knowledge of environmentally-induced DNA methylation changes, which is essential regarding the increasing frequency of global climate changes.
Keywords: DNA methylation, duckweed, epigenetics, epiGBS, abiotic stress, transgenerational inheritance, asexual reproduction
Published in DKUM: 29.01.2019; Views: 1617; Downloads: 127
.pdf Full text (2,81 MB)

Bacterial chemotaxis and entropy production
Paško Županović, Milan Brumen, Marko Jagodič, Davor Juretić, 2010, original scientific article

Abstract: Entropy production is calculated for bacterial chemotaxis in the case of a migrating band of bacteria in a capillary tube. It is found that the speed of the migrating band is a decreasing function of the starting concentration of the metabolizable attractant. The experimentally found dependence of speed on the starting concentration of galactose, glucose and oxygen is fitted with power-law functions. It is found that the corresponding exponents lie within the theoretically predicted interval. The effect of the reproduction of bacteria on band speed is considered, too. The acceleration of the band is predicted due to the reproduction rate of bacteria. The relationship between chemotaxis, the maximum entropy production principle and the formation of self-organizing structure is discussed.
Keywords: biofizika, bakterijska kemotaksa, hitrost reprodukcije, princip maksimalne produkcije entropije, biophysics, bacterial chemotaxis, reproduction rate, princip maksimalne produkcije entropije
Published in DKUM: 10.07.2015; Views: 1277; Downloads: 92
URL Link to full text

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