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ACQUIRING TEMPORAL KNOWLEDGE FOR MAKING DECISIONS IN MEDICAL PROCESSES
Aida Kamišalić Latifić, 2014, doctoral dissertation

Abstract: A medical process is a set of medical actions performed by healthcare professionals while making observations about signs and symptoms, ordering interventions, prescriptions, tests, and any other actions in order to solve a health problem that is affecting a particular patient. The objective is to offer a curative, chronic, palliative and/or symptomatic treatments. The capability of a physician to propose an appropriate treatment depends on his/her knowledge of similar clinical cases and by following advances in the treatment of particular diseases. Time is an important concept of the real world that has to be considered in regard to medical processes. Clinical Practice Guidelines (CPGs) are a narrative set of recommendations for treating patients suffering from a particular disease. By constantly referring to CPGs physicians can stay up to date with the best evidence-based medical care and with the recommendations of experts. The time dimension is, however, often omitted or only partially covered in CPGs. Some CPGs do contain certain recommendations considering time but often there are huge gaps that are supposed to be overcome by physicians’ own knowledge and experience. At the same time, healthcare centres hold healthcare records and information systems that register medical processes and patients data, including information about the times of any encounters, prescriptions, and other medical actions. Therefore healthcare records and information systems data can be a source for detecting temporal medical knowledge and sound evidence regarding healthcare. This thesis is centred on temporal knowledge acquisition and representation for the purposes of decision-making during medical processes. CPGs were analysed to obtain procedural knowledge models and Extended Timed Transition Diagrams defined for representations of the obtained knowledge. The data about the treatments of patients were analysed in order to detect temporal medical knowledge models that represented those medical procedures that were carried out while the data was being generated. These models thus provided an explicit representation of the time dimensions of past medical procedures. They could be used for complementing the knowledge provided by CPGs, for studying adherences to the CPGs and for representing a basic framework for medical procedural decision support systems development.
Keywords: knowledge acquisition, knowledge representation, temporal knowledge, decision-making, medical processes, procedural knowledge modelling
Published: 25.02.2014; Views: 1134; Downloads: 92
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3.
Stern polynomials
Sandi Klavžar, Uroš Milutinović, Ciril Petr, 2005

Abstract: Sternovi polinomi ▫$B_k(t)$▫, ▫$k ge 0$▫, ▫$t in RR$▫, so vpeljani na naslednji način: ▫$B_0(t) = 0$▫, ▫$B_1(t) = 1$▫, ▫$B_{2n}(t) = tB_n(t)$▫ in ▫$B_{2n+1}(t) = B_{n+1}(t) + B_n(t)$▫. Pokazano je, da ima ▫$B_n(t)$▫ enostavno eksplicitno reprezentacijo s hiperebinarnimi reprezentacijami ▫$n-1$▫ in da je odvod ▫$B'_{2n-1}(0)$▫ enak številu enic v standardni Grayjevi kodi za ▫$n-1$▫. Dokazano je tudi, da je stopnja polinoma ▫$B_n(t)$▫ enaka razliki med dolžino in težo nesosednje predstavitve števila ▫$n$▫.
Keywords: matematika, Sternovo (dvoatomsko) zaporedje, Sternovi polinomi, hiperbinarna reprezentacija, standardna Grayjeva koda, nesosednja predstavitev, mathematics, Stern (diatomic) sequence, Stern polynomials, hyperbinary representation, standard Gray code, non-adjacent form
Published: 10.07.2015; Views: 692; Downloads: 16
URL Link to full text

4.
On the canonical metric representation, average distance, and partial Hamming graphs
Sandi Klavžar, 2006, original scientific article

Abstract: Povprečna razdalja grafa je izražena s pomočjo kanonične metrične reprezentacije. Enakost lahko preoblikujemo v neenakost tako, da karakterizira izometrične podgrafe Hammingovih grafov. Ta pristop poenostavlja prepoznavanje teh grafov ter izračun povprečne razdalje.
Keywords: matematika, teorija grafov, kanonična metrična reprezentacija, Hammingovi grafi, delni Hammingovi grafi, Wienerjev indeks, algoritem prepoznavanja, mathematics, graph theory, cononical metric representation, Hamming graphs, partial Hamming graphs, Wiener index, recognition algorithm
Published: 10.07.2015; Views: 489; Downloads: 60
URL Link to full text

5.
Stern polynomials
Sandi Klavžar, Uroš Milutinović, Ciril Petr, 2007, original scientific article

Abstract: Sternovi polinomi ▫$B_k(t)$▫, ▫$k ge 0$▫, ▫$t in RR$▫, so vpeljani na naslednji način: ▫$B_0(t) = 0$▫, ▫$B_1(t) = 1$▫, ▫$B_{2n}(t) = tB_n(t)$▫ in ▫$B_{2n+1}(t) = B_{n+1}(t) + B_n(t)$▫. Pokazano je, da ima ▫$B_n(t)$▫ enostavno eksplicitno reprezentacijo s hiperebinarnimi reprezentacijami ▫$n-1$▫ in da je odvod ▫$B'_{2n-1}(0)$▫ enak številu enic v standardni Grayjevi kodi za ▫$n-1$▫. Dokazano je tudi, da je stopnja polinoma ▫$B_n(t)$▫ enaka razliki med dolžino in težo nesosednje predstavitve števila ▫$n$▫.
Keywords: matematika, Sternovo (dvoatomsko) zaporedje, Sternovi polinomi, hiperbinarna reprezentacija, standardna Grayjeva koda, nesosednja predstavitev, mathematics, Stern (diatomic) sequence, Stern polynomials, hyperbinary representation, standard Gray code, non-adjacent form
Published: 10.07.2015; Views: 483; Downloads: 15
URL Link to full text

6.
New spectral numerical characterization of DNA sequences
Igor Pesek, Janez Žerovnik, 2008, original scientific article

Abstract: We present new numerical characterization of DNA sequences that is based on the modified graphical representation proposed by Hamori. While Hamori embeds the sequence into Euclidean space, we use analogous embedding into the stron gproduct of graphs, ▫$K_4 boxtimes P_n$▫, with weighted edges. Based on this representation, a novel numerical characterization was proposed in [Pesek and Zerovnik, MATCH Commun. Math. Comput. Chem. (Krag.), vol 60, 2008, 301-312] which is based on the products of ten eigenvalues from the start and the end of the descending ordered list of the eigenvalues of the ▫$L/L$▫ matrices associated with DNA. In this paper we compare two further numerical characterizations of the same type emphasizing the robustness of the approach.
Keywords: matematika, grafična reprezentacija, numerična karakterizacija, grafovska invarianta, DNK zaporedje, mathematics, graphical representation, numerical characterization, graph invariant, DNA sequence
Published: 10.07.2015; Views: 544; Downloads: 25
URL Link to full text

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