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Particulate matter air pollution in the Republic of Slovenia and its national spatial emissions release
Petra Dolšak Lavrič, Maja Ivanovski, Darko Goričanec, Danijela Urbancl, 2023, original scientific article

Abstract: In this work, an impact of particulate matter (PM) on air pollution and its emissions released is investigated. Concentration levels of PM10 and PM2.5 in the Republic of Slovenia (RS) were analyzed on daily, weekly, monthly, quartile, and annual data and then compared. The study was conducted from January 1, 2020 to December 31, 2020 at two monitoring stations, so-called urban traffic and urban industrial. Obtained results showed that the highest concentrations of PM in air were during the cold months of the year when the temperatures are lower (< 6%). Results from heating seasons (from October 1, 2019 and March 31, 2020 and from October 1, 2020 to March 31, 2021) showed the highest concentration levels of PM10 between 9:00 and 14:00 and between 18:00 and 22:00, with highest concentrations recorded during the winter months (January and February). Additionally, emission building inventory was built based on PM10 and PM2.5 emissions released. The study includes yearly spatial building emissions release model considering currently installed high PM emitted stoves. The building model for the Republic of Slovenia has been developed by using 500 x 500 m model grid. Obtained results showed that changing currently low efficient appliance with advanced appliance would result in significant lower PM emissions released from building sector
Keywords: air pollution, particulate matter, heating season, emission release, Slovenia
Published in DKUM: 10.05.2024; Views: 157; Downloads: 4
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Development of pH Responsive Polysaccharide Based Wound Dressings : doctoral disertation
Beste Elveren, 2023, doctoral dissertation

Abstract: In the scope of the Doctoral Dissertation, a polysaccharide based stimuli-responsive smart material with controlled drug release was developed by using electrospinning technique, which allowed to form stimuli-responsive nanofibers with rapid visual detection of pH change in the wound bed along with anti-inflammatory activity. Incorporation of halochromic dyes into electrospun nanofibers has been an intriguing area for wound healing applications. Furthermore, it is known that the pH value within the wound milieu directly and indirectly influences all biochemical reactions taking place in the process of wound healing. It has been proven that the surface pH of a wound plays an important role in wound healing as it helps control infection and increases the antimicrobial activity, oxygen release, angiogenesis, protease activity, and bacterial toxicity. Therefore, visual pH monitoring without the need of removing the wound dressing was one of the aims of the Doctoral Dissertation. Produced stimuli-responsive wound dressings were characterized according to their morphological and chemical properties using well-known techniques such as, rheometry, conductivity, Scanning Electron Microscopy (SEM),CIE Lab, Thermogravimetric Analysis (TGA), UV/VIS Spectrophotometry, and Attenuated Total Reflection Infra-Red Spectroscopy (ATR-IR). Responsiveness of the nanofibers were achieved by integration of different halochromic dyes [bromocresol green (BCG), bromothymol blue (BTB) and thymol blue (TB)] to obtain a range of pH values. To tackle the problem of leaching of the dyes, a complexing agent; poly-diallyldimethylammonium chloride (PDADMAC) was integrated and an analysis on the formation of complexation was performed by using pH-potentiometric titration and Quartz Crystal Microbalance with Dissipation (QCM-D) and Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS) techniques. Additionally, release tests were performed to prove that the leaching of the halochromic dyes is reduced significantly up to 97%. Furthermore, the responsiveness of the nanofibers was investigated by exposing the nanofibers to different buffer solutions with pH values 4, 7 and 10. The color change of the nanofibers were analyzed using the CIE Lab system while a visual color shift was observed according to their characteristics. Lastly, diclofenac (DFC), an anti-inflammatory drug molecule was integrated to the system and drug release studies were performed by using Franz diffusion cells. A controlled release of the drug molecule (DFC) to the wound bed is achieved and quantitative evaluations were done. Consequently, the drug release from the smart wound dressings were identified to have two separate profiles during the release. The mathematical models that were identified to fit to the kinetics are, first-order, Korsmeyer-Peppas, and Higuchi release model, confirming the controlled drug release.
Keywords: stimuli-responsive, polysaccharides, wound dressings, halochromism, controlled drug release, smart materials
Published in DKUM: 06.10.2023; Views: 353; Downloads: 32
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The importance of the correct choice of Franz diffusion cell volume for in vitro drug release testing of wound dressings
Tina Maver, Uroš Maver, 2022, original scientific article

Keywords: in vitro drug release testing, Franz diffusion cells, simulation, naproxen, alginate
Published in DKUM: 16.02.2023; Views: 593; Downloads: 49
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Exocytosis of insulin in vivo maturation of mouse endocrine pancreas
Aldo Rozzo, Tiziana Meneghel-Rozzo, Saška Lipovšek Delakorda, Shi-Bing Yang, Marjan Rupnik, 2009, published scientific conference contribution

Abstract: The aim of this study was to define when an insulin-positive cell becomes functional in vivo and starts to exocytose insulin in a regulated nutrient-dependent manner. Insulin-positive cells appear in embryonic life (midgestation) and complete their maturation, presumably around birth. In order to work with embryonic and newborn endocrine pancreas, we used organotypic slices. The mouse embryonic pancreas slices show high basal insulin release that is not further elevated by high glucose levels. Despite the presence of functional voltage-activated ion channels, the cells are not electrically active in the presence of secretagogues. At birth, the high basalinsulin release drops and, after postnatal day 2, the insulin-positive cells show both adult-like bursting electrical activity and hormone release induced by high glucose levels. These properties allowed us to define them as beta cells. Despite the apparent stability of the transcription factor profile reported in insulin-positive cells during late-embryonic life, functional beta cells appear only 2 days after birth.
Keywords: cell biology, insulin release, embrios, newborn, beta-cell maturation, developing pancreas
Published in DKUM: 07.06.2012; Views: 1490; Downloads: 28
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Binding silver nano-particles onto viscose non-woven using different commercial sol-gel procedures
Tanja Pivec, Zdenka Peršin Fratnik, Silvo Hribernik, Tina Maver, Mitja Kolar, Karin Stana-Kleinschek, 2012, original scientific article

Abstract: The paper presents possible solution of Ag binding using commercial sol-gel systems which enable its low release into a wound, providing a good antimicrobial effect on those bacterial cultures that are most likely present in the wound. The influence of different sol-gel systems on the hydrophilic properties of carrier materials and the level of released silver has been studied. The results showed that sol-gel as binding-systems could provide proper hydrophilic properties of material, whilst binding silver strongly enough providing at the same time excellent antimicrobial activity of the treated viscose meterials.
Keywords: silver nano-particles, sol-gel, viscose non-woven, silver release, hydrophilicity, antimicrobial properties
Published in DKUM: 01.06.2012; Views: 3188; Downloads: 103
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