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Induction gemcitabine in standard dose or prolonged low-dose with cisplatin followed by concurrent radiochemotherapy in locally advanced non-small cell lung cancer
Martina Vrankar, Matjaž Zwitter, Tanja Bavčar-Vodovnik, Ana Milič, Viljem Kovač, 2014, izvirni znanstveni članek

Opis: Background: The optimal combination of chemotherapy with radiation therapy for treatment locally advanced non-small cell lung cancer (NSCLC) remains an open issue. This randomized phase II study compared gemcitabine in two different schedules and cisplatin - as induction chemotherapy, followed by radiation therapy concurrent with cisplatin and etoposid. Patients and methods: Eligible patients had microscopically confirmed inoperable non-metastatic non-small cell lung cancer; fulfilled the standard criteria for platin-based chemotherapy; and signed informed consent. Patients were treated with 3 cycles of induction chemotherapy with gemcitabine and cisplatin. Two different aplications of gemcitabine were compared: patients in arm A received gemcitabine at 1250 mg/m2 in a standard half hour i.v. infusion on days 1 and 8; patients in arm B received gemcitabine at 250 mg/m2 in prolonged 6-hours i.v. infusion on days 1 and 8. In both arms, cisplatin 75 mg/m2 on day 2 was administered. All patients continued treatment with radiation therapy with 60-66 Gy concurrent with cisplatin 50 mg/m2 on days 1, 8, 29 and 36 and etoposid 50 mg/m2 on days 1-5 and 29-33. The primary endpoint was response rate (RR) after induction chemotherapy; secondary endpoints were toxicity, progression-free survival (PFS) and overall survival (OS). Results: From September 2005 to November 2010, 106 patients were recruited to this study. No statistically signifficant differences were found in RR after induction chemotherapy between the two arms (48.1% and 57.4%, p = 0.34). Toxicity profile was comparable and mild with grade 3/4 neutropenia as primary toxicity in both arms. One patient in arm B suffered from acute peripheral ischemia grade 4 and an amputation of lower limb was needed. With a median follow-up of 69.3 months, progression-free survival and median survival in arm A were 15.7 and 24.8 months compared to 18.9 and 28.6 months in arm B. The figures for 1- and 3-year overall survival were 73.1% and 30.8% in arm A, and 81.5 % and 44.4% in arm B, respectively. Conclusions: Among the two cisplatin-based doublets of induction chemotherapy for inoperable NSCLC, both schedules of gemcitabine have a comparable toxicity profile. Figures for RR, PFS and OS are among the best reported in current literature. While there is a trend towards better efficacy of the treament with prolonged infusion of gemcitabine, the difference between the two arms did not reach statistical significance.
Ključne besede: induction chemotherapy, non-small cell lung cancer, radiation therapy, randomized clinical trial
Objavljeno: 05.04.2017; Ogledov: 594; Prenosov: 59
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Wave motion in infinite inhomogeneous waveguides
Igor Špacapan, Miroslav Premrov, 2003, izvirni znanstveni članek

Opis: The analysis of wave motion in infinite homogeneous waveguides, having a complicated cross-section and/or an irregular inclusion, is a rather difficult task for the majority of available methods, especially when striving for accurate results. In contrast, this presented procedure performed in the frequency domain, is simple to apply. It yields correct results because the radiation conditions are considerably accurately satisfied, and it offers a clear parametric insight into wave motion. This procedure uses the FE modelling of an analysed section of the waveguide. It is based on the decomposition of wave motion, distinguishing propagating and non-propagating wavemodes by solving the eigenvalue problem. The presented examples demonstrate the effectiveness of this procedure, whilst a comparison between computed and analytical results demonstrates its accuracy.
Ključne besede: waves, wavemodes, waveguides, inhomogeneity, finite element method, parametric analysis, radiation conditions, eigenvalue problem, frequency domain
Objavljeno: 01.06.2012; Ogledov: 1547; Prenosov: 45
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Solving exterior problems of wave propagation based on an iterative variation of local DtN operators
Miroslav Premrov, Igor Špacapan, 2004, izvirni znanstveni članek

Opis: This paper discusses the problem of wave reflection from the fictitious boundary, with particular regard to the higher harmonic modes. This problem occurs when solving the wave equation in exterior domains using an asymptotic local low-order Dirichlet-to-Neumann (DtN) map for computational procedures applied to a finite domain. We demonstrate that the amplitudes of the reflected fictitious harmonics depend on the wave number, the location of the fictitious boundary, as well as on the local DtN operator used in the computations. Moreover, we show that a constant value of the asymptotic local low-order operator cannot sufficiently eliminate the amplitudes of all reflected waves, and that the results are poor especially for higher harmonics. We propose therefore an iterative method, which varies the tangential dependence of the local operator in each computational step. We only discuss some logical and interesting choices for the operators although this method permits several possibilities on how to vary the operator. The method is simple to apply and the presented examples demonstrate that the accuracy is considerably improved by iterations.
Ključne besede: wave motion, infinite domains, fictitious boundary, radiation condition, finite element method, Dirichlet-to-Neumann map
Objavljeno: 01.06.2012; Ogledov: 1161; Prenosov: 60
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The influence of increased cross-linker chain length in thermosensitive microspheres on potential sun-protection activity
Witold Musiał, Vanja Kokol, Bojana Vončina, 2010, izvirni znanstveni članek

Opis: The sun protection should involve substances with protecting activity against both UVB and UVA radiation. In this research the evaluation of thermosensitive microspheres as potential molecules for sunscreen formulations was approached, using modified Boots star rating system. The microspheres, thermosensitive N-isopropylacrylamide derivatives, have potential protecting activity against UV radiation. The MX and DX microspheres, with ethylene glycol dimethacrylate and diethylene glycol dimethacrylate crosslinker respectively, due to theirs thermosensitivity exhibit increase in protecting activity against UV radiation when heated to 45°C. The MX microspheres have higher increase in terms of UV absorbance, comparing to DX microspheres, when heated in the 25°C to 45°C range. Studied microspheres have high potential forapplication as components of sun-screens used in elevated temperatures.
Ključne besede: thermosensitive microspheres, ethylene glycol dimethacrylate, diethylene glycol dimethacrylate, ultraviolet radiation, sun-screen
Objavljeno: 31.05.2012; Ogledov: 1096; Prenosov: 20
URL Povezava na celotno besedilo

Evaluation of thermosensitive microspheres as potential components for sun-protectors
Witold Musiał, Vanja Kokol, Bojana Vončina, 2010, izvirni znanstveni članek

Opis: In this study thermosensitive polymeric microspheres obtained in former research were evaluated in vitro for their photoprotective activity. The UVA/UVB ratio was assessed at so called shelf temperature i.e. at 25°C, and at elevated temperature of 45°C. The evaluated polymers absorb higher levels of UV radiation, when heated from 25°C to 45°C. The MS1 polymer may be defined as polymer with high efficiency in the terms of gaining protection against UVAradiation, when heated. The MS2 absorbs both UVA and UVB radiation, and maybe considered, as most protective, when heated to 45°C. The equalized and less strong activity has the polymer MS3 when heated, with lipophilic radical implemented during synthesis.
Ključne besede: thermosensitive polymers, photoprotection, UV radiation, N-isopropylacrylamide
Objavljeno: 31.05.2012; Ogledov: 1104; Prenosov: 24
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Wowen fabric and ultraviolet protection
Polona Dobnik-Dubrovski, 2010, samostojni znanstveni sestavek ali poglavje v monografski publikaciji

Ključne besede: UV radiation, sun protection, constructional parameters
Objavljeno: 31.05.2012; Ogledov: 1273; Prenosov: 90
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