1. Hemodynamic response to high- and low-load resistance exercise in patients with coronary artery disease : a randomized, crossover clinical trialTim Kambič, Vedran Hadžić, Mitja Lainščak, 2021, original scientific article Abstract: Low-load resistance exercise (LL-RE) is recommended as an adjunct therapy to aerobic exercise during cardiac rehabilitation in patients with coronary artery disease. The safety and hemodynamic response to high-load (HL) RE remain unknown. The aim of this study was to evaluate the hemodynamic response during both HL-RE and LL-RE prior to cardiac rehabilitation. Forty-three patients with coronary artery disease and/or percutaneous coronary intervention performed three sets of leg-press exercise using HL-RE (eight repetitions at the intensity of 80% of one repetition maximum (1-RM)) and LL-RE (16 repetitions at the intensity of 40% 1-RM) in a randomized crossover sequence. Heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), and rating of perceived exertion were measured at baseline, after each set of RE and post-exercise. No clinically relevant changes in HR and BP or in patient-reported symptoms were recorded during HL-RE or LL-RE. Compared with baseline, HR and SBP increased during LL-RE (from 66 bpm to 86 bpm, time effect: p < 0.001; from 129 mmHg to 146 mmHg, time effect: p < 0.001) and HL-RE (from 68 bpm to 86 bpm, time effect: p < 0.001; from 130 mmHg to 146 mmHg, time effect: p < 0.001). Compared with HL-RE, the increase in HR was greater after the final set of LL-RE (32% vs. 28%, p = 0.015), without significant differences in SBP and DBP between LL-RE and HL-RE. Rating of perceived exertion was higher after the 1st set of HL-RE compared with LL-RE (median (interquartile range): 6 (5–7) vs. 6 (5–6), p = 0.010). In patients with coronary artery disease, both HL-RE and LL-RE were safe and well-tolerated. Hemodynamic changes were similar and within the physiological response to RE.
Keywords: sport, cardiac rehabilitation, resistance training, blood pressure, heart rate
Published in DKUM: 20.08.2024; Views: 85; Downloads: 10
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2. Impact of short-term topical steroid therapy on selective laser trabeculoplasty efficacyTomaž Gračner, 2021, original scientific article Abstract: Background: To evaluate whether short-term use of topical steroid therapy affected the efficacy of selective laser trabeculoplasty (SLT) for primary open-glaucoma (POAG). Methods: 25 eyes of 25 patients, who used a drop of dexamethasone 0.1% 4 times a day for 7 days as post-laser therapy, formed the Steroid SLT group and 24 eyes of 24 patients, where no topical steroids or nonsteroidal anti-inflammatory agents as post-laser therapy were used, formed the No-steroid SLT group. Success was defined as an intraocular pressure (IOP) lowering exceeding 20% of pretreatment IOP. Results: The mean follow-up time was 21.24 months for the Steroid SLT group and 20.25 months for the No-steroid SLT group (p = 0.990). No significant difference was found between the two groups for mean pretreatment IOP (22.20 mmHg vs. 22.33 mmHg), and for mean IOP reductions during whole follow-up period. At all follow-up visits, the mean IOP reductions were smaller in the Steroid SLT group than in the No-steroid SLT group. At all follow-up visits, the mean percent IOP reduction was smaller in the Steroid SLT group than in the No-steroid SLT group, and such a difference was significant at 12 months (25.4% vs. 29.6%, p = 0.047) and 24 months (25.3% vs. 29.7%, p = 0.024). According to the Kaplan–Meier survival analysis, the 24-month success rate was 84% in the Steroid SLT group and 79.2% in the No-steroid SLT group, with no differences between the groups (p = 0.675). Conclusion: Short-term use of topical steroid therapy had no impact on the efficacy of SLT for POAG.
Keywords: selective laser trabeculoplasty, topical steroid therapy, primary open-angle glaucoma, intraocular pressure
Published in DKUM: 14.08.2024; Views: 122; Downloads: 7
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3. Telemonitoring of elderly with hypertension and type 2 diabetes at the primary care level : protocol for a multicentric randomized controlled pilot studyMatic Mihevc, Črt Zavrnik, Majda Mori-Lukančič, Tina Virtič, Valentina Prevolnik Rupel, Marija Petek Šter, Zalika Klemenc-Ketiš, Tonka Poplas-Susič, 2022, original scientific article Abstract: Introduction: Arterial hypertension (AH) and type 2 diabetes (T2D) represent a significant burden for the public health system, with an exceptionally high prevalence in patients aged ≥65 years. This study aims to test the acceptability, clinical effectiveness, and cost-effectiveness of telemonitoring in elderly patients with AH and T2D at the primary care level.
Methods: A m ulti-centre, prospective, randomized, controlled t rial w ill be conducted. Patients a ged ≥ 65 y ears with AH and T2D will be randomized in a 1:1 proportion to a mHealth intervention or standard care group. Patients in the intervention group will measure their blood pressure (BP) twice weekly and blood glucose (BG) once monthly. The readings will be synchronously transmitted via a mobile application to the telemonitoring platform, where they will be reviewed by a general practitioner who will indicate changes in measurement regimen or carry out a teleconsultation. The primary endpoint will be a change in systolic BP (SBP) and glycated haemoglobin (HbA1c) relative to standard care up to 12 months after inclusion. Secondary endpoints will be a change in other observed clinical variables, quality-of-life indexes, and costs.
Expected results: Telemonitoring will be an acceptable method of care associated with significant reductions in SBP and HbA1c levels and an increase in quality-of-life indexes in the intervention group. However, the cost-effectiveness threshold (incremental cost-effectiveness ratio below €25,000/quality-adjusted life year) might not be reached.
Conclusion: This study will provide new evidence for scaling up telemonitoring network at the primary care level and modifying telemonitoring protocols to achieve the best clinical and cost-effective outcomes.
Keywords: mobile health, telemonitoring, blood pressure, blood glucose, HbA1c, aged, primary health care, costs
Published in DKUM: 27.06.2024; Views: 178; Downloads: 8
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4. Loss of oxygen atoms on well-oxidized cobalt by heterogeneous surface recombinationDomen Paul, Miran Mozetič, Rok Zaplotnik, Jernej Ekar, Alenka Vesel, Gregor Primc, Denis Đonlagić, 2023, original scientific article Abstract: Calorimetry is a commonly used method in plasma characterization, but the accuracy of the method is tied to the accuracy of the recombination coefficient, which in turn depends on a number of surface effects. Surface effects also govern the kinetics in advanced methods such as atomic layer oxidation of inorganic materials and functionalization of organic materials. The flux of the reactive oxygen atoms for the controlled oxidation of such materials depends on the recombination coefficient of materials placed into the reaction chamber, which in turn depends on the surface morphology, temperature, and pressure in the processing chamber. The recombination coefficient of a well-oxidized cobalt surface was studied systematically in a range of temperatures from 300 to 800 K and pressures from 40 to 200 Pa. The coefficient increased monotonously with decreasing pressure and increasing temperature. The lowest value was about 0.05, and the highest was about 0.30. These values were measured for cobalt foils previously oxidized with oxygen plasma at the temperature of 1300 K. The oxidation caused a rich morphology with an average roughness as deduced from atomic force images of 0.9 µm. The results were compared with literature data, and the discrepancy between results reported by different authors was explained by taking into account the peculiarities of their experimental conditions.
Keywords: heterogeneous surface recombination, recombination coefficient, cobalt, cobalt oxide, temperature dependence, pressure dependence, plasma, oxygen
Published in DKUM: 26.03.2024; Views: 228; Downloads: 18
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5. Cavitation erosion modelling : comparison of different driving pressure approachesLuka Kevorkijan, Marko Pezdevšek, Ignacijo Biluš, Gorazd Hren, 2023, original scientific article Abstract: In this paper we compared different driving pressure approaches to calculate the cavitation potential energy from a source, which is transferred to a surface. The first approach used the reference pressure, the second approach used the pressure calculated at each timestep with no averaging, the third approach used the averaged pressure values from all timesteps included in one shedding cycle, and the last approach used pressure values from the steady state simulations results. The results show that for all formulations the averaged pressure values and steady state pressure values give similar results in terms of mean potential power distribution on the hydrofoil surface as in absolute values. The reference pressure approach gave similar results for the derivative and divergence formulation while for the source term the mean potential power distribution on the hydrofoil surface differs and the maximums were near the leading edge. The approach where we used no pressure averaging gave adequate results in terms of mean potential power distribution but differs from other approaches in absolute values which were considerably lower for all potential power formulations.
Keywords: cavitation, erosion potentional, driving pressure, numerical simulations
Published in DKUM: 21.02.2024; Views: 400; Downloads: 23
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6. Development of an experimental Dead-End microfiltration layout and process repeatability analysisGorazd Bombek, Luka Kevorkijan, Grega Hrovat, Drago Kuzman, Aleks Kapun, Jure Ravnik, Matjaž Hriberšek, Aleš Hribernik, 2024, original scientific article Abstract: Microfiltration is an important process in the pharmaceutical industry. Filter selection and validation is a time-consuming and expensive process. Quality by design approach is important for product safety. The article covers the instrumentalization and process control of a laboratory-scale dead-end microfiltration layout. The layout is a downscale model of the actual production line, and the goal is filter validation and analysis of process parameters, which may influence filter operation. Filter size, fluid pressure, valve plunger speed, and timing issues were considered. The focus is on the identification of the most influential process parameters and their influence on the repeatability of pressure oscillations caused by valve opening. The goal was to find the worst-case scenario regarding pressure oscillations and, consequently, filter energy intake. The layout was designed as compact as possible to reduce pressure losses between the filter and valve. Valve-induced pressure oscillations proved to be prevailing over the water hammer effect. Several filters in sizes between 3.5 cm2 and 6900 cm2 were tested, and some recommendations were suggested for the reduction of energy intake of the filter and to improve the repeatability of the process.
Keywords: filtration, pressure oscillations, repeatability, processes, parameters
Published in DKUM: 01.02.2024; Views: 425; Downloads: 25
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7. Microwave Synthesis of Poly(Acrylic) Acid-Coated Magnetic Nanoparticles as Draw Solutes in Forward OsmosisSabina Vohl, Irena Ban, Mihael Drofenik, Hermina Bukšek, Sašo Gyergyek, Irena Petrinić, Claus Hélix-Nielsen, Janja Stergar, 2023, original scientific article Abstract: Polyacrylic acid (PAA)-coated magnetic nanoparticles (MNP@PAA) were synthesized and evaluated as draw solutes in the forward osmosis (FO) process. MNP@PAA were synthesized by microwave irradiation and chemical co-precipitation from aqueous solutions of Fe2+ and Fe3+ salts. The results showed that the synthesized MNPs have spherical shapes of maghemite Fe2O3 and superparamagnetic properties, which allow draw solution (DS) recovery using an external magnetic field. Synthesized MNP, coated with PAA, yielded an osmotic pressure of ~12.8 bar at a 0.7% concentration, resulting in an initial water flux of 8.1 LMH. The MNP@PAA particles were captured by an external magnetic field, rinsed in ethanol, and re-concentrated as DS in repetitive FO experiments with deionized water as a feed solution (FS). The osmotic pressure of the re-concentrated DS was 4.1 bar at a 0.35% concentration, resulting in an initial water flux of 2.1 LMH. Taken together, the results show the feasibility of using MNP@PAA particles as draw solutes.
Keywords: magnetic nanoparticles, microwave synthesis, polyacrilic acid, osmotic pressure, draw solution, forward osmosis
Published in DKUM: 05.12.2023; Views: 433; Downloads: 20
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8. P-x,y equilibrium data of the binary systems of 2-propanol, 1-butanol and 2-butanol with carbon dioxide at 313.15 K and 333.15 KDragana Borjan, Maša Knez Marevci, Željko Knez, 2022, original scientific article Abstract: The ability to predict the behaviour of high-pressure mixtures of carbon dioxide and alcohol is important for industrial purposes. The equilibrium composition of three binary carbon dioxide-alcohol systems was measured at temperatures of 313.15 K and 333.15 K and at pressures of up to 100 bar for carbon dioxide-2-propanol, up to 160 bar for carbon dioxide-1-butanol and up to 150 bar for carbon dioxide-2-butanol. Different equilibrium compositions of carbon dioxide in alcohols were observed despite their similar molecular weight (M2-propanol = 60.100 g mol−1, M1-butanol = 74.121 g mol−1 and M2-butanol = 74.122 g mol−1) and place in the functional hydroxyl group (first or second carbon molecule). It is assumed that the differences in the phase equilibria are due to different vapor pressures, polarities and solute-solute interactions.
Keywords: high-pressure phase equilibrium, carbon dioxide, 2-propanol, 1-butanol, 2-butanol
Published in DKUM: 17.08.2023; Views: 420; Downloads: 43
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9. Time pressure, work-related spousal support seeking, and relationship satisfaction : spillover and crossover effects among dual-earner couplesSara Tement, Katarina Katja Mihelič, Bettina Kubicek, 2023, original scientific article Abstract: The present study examined how time pressure at work is transmitted to the home domain and how it affects individuals’ (spillover) as well as their partners’ relationship satisfaction (crossover). We examined the role of work-related spousal support seeking and proposed that it serves as a mediator of the spillover as well as the crossover process. We further explored whether the proposed spillover-crossover process is gender-contingent. Using a sample of 308 dual-earner couples, we found support for a positive link between time pressure at work and spousal support seeking. As hypothesized, spousal support seeking served also as a crossover mechanism. However, distinct spillover and crossover processes were found for men and women. These findings not only point to a new spillover and crossover mechanism but also highlight gender-specific patterns in the role of support seeking. As this coping strategy is feasible when job stressors are high, it should be considered a part of stress management trainings and organizational practices.
Keywords: spillover, crossover, time pressure, dual-earner couples, work-related spousal support, relationship satisfaction, gender differences
Published in DKUM: 13.07.2023; Views: 452; Downloads: 53
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10. Interleukin response in patients treated with abbreviated laparotomy for severe intraabdominal sepsisTomaž Jagrič, Maksimiljan Gorenjak, Evgenija Homšak, Bojan Krebs, 2022, original scientific article Keywords: intraabdominal sepsis, surgery, negative wound pressure therapy, interleukin-6, interleukin-10
Published in DKUM: 16.02.2023; Views: 573; Downloads: 55
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