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1.
Trends on maternal mortality in the Republic of Benin and comparison with the neighboring countries
Romeo Konnon, Said Semyatov, Muhammednazar Soyunov, Zalina Sokhova, Tatevik Zulumyan, 2020, original scientific article

Abstract: The maternal mortality ratio in the Republic of Benin in 2015 was still high - 405 per 100,000 live births. The delay in consultation and timely treatment, unavailability of medical facilities and lack of skilled care are the principal factors contributing to maternal deaths in Benin. Consequently, the rate of such preventable causes of maternal deaths like obstetric haemorrhage (38.40 percent and pre-eclampsia/eclampsia (14.30 percent) remains high in the country, and even HIV continued being one of the indirect causes of maternal deaths in 2017 - one percent. High rate of complications associated with pregnancy and birth in adolescent girls is another cause of maternal deaths in the Republic of Benin. Despite the efforts of the Government aimed at improving health care, it is unlikely that we will achieve the United Nations Sustainable Development Goals 3.1. - the reduction of maternal mortality ratio to less than 70 per 100,000 live births by 2030.
Keywords: maternal mortality ratio, adolescent pregnancy, haemorrhage, pre-eclampsia/eclampsia, Republic of Benin
Published: 15.01.2021; Views: 50; Downloads: 40
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2.
Some regulatory dilemmas of artificial termination of pregnancy in Slovenian and comparative law
Viktorija Žnidaršič Skubic, 2017

Abstract: The article deals with the issue of the artificial termination of pregnancy through the prism of, typically, conflicting relations between the subjects involved and their interests. It specifically addresses the most contentious and morally-ethically as well as legally complicated relationship between the pregnant woman (the future mother) and the embryo or pre-embryo. The article explains the positions of legal theory and jurisprudence in Slovenia and abroad regarding the status of an embryo as a legal person. The authoress moreover touches the question of legal status of the (potential future) father of such an embryo and presents regulations dealing with artificial termination of pregnancy in domestic and comparative law. Through a schematic summary of typical characteristics of such regulations around the world, which greatly differs in details, the author highlights their basic characteristics as well as individual trends in the field.
Keywords: artificial termination of pregnancy, abortion, legal status of embryo, reproductive autonomy, right to the artificial termination of pregnancy
Published: 09.10.2018; Views: 656; Downloads: 151
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3.
Non-invasive prenatal cell-free fetal DNA testing for down syndrome and other chromosomal abnormalities
Darija Strah, Petra Ovniček, Janez Bernik, 2015, original scientific article

Abstract: Background: Chorionic villus sampling and amniocentesis as definitive diagnostic procedures represent a gold standard for prenatal diagnosis of chromosomal abnormalities. The methods are invasive and lead to a miscarriage and fetal loss in approximately 0.5–1 %. Non-invasive prenatal DNA testing (NIPT) is based on the analysis of cell-free fetal DNA from maternal blood. It rep- resents a highly accurate screening test for detecting the most common fetal chromosomal abnormalities. In our study we present the results of NIPT testing in the Diagnostic Center Strah, Slovenia, over the last 3 years. Methods: In our study, 123 pregnant women from 11th to 18th week of pregnancy were included. All of them had First trimester assessment of risk for trisomy 21, done before NIPT testing. Results: 5 of total 6 high-risk NIPT cases (including 3 cases of Down syndrome and 2 cases of Klinefelter’s syndrome) were confirmed by fetal karyotyping. One case–Edwards syndrome was false positive. Patau syndrome, triple X syndrome or Turner syndrome were not observed in any of the cases. Furthermore, there were no false negative cases reported. In general, NIPT testing had 100 % sensitivity (95 % confidence interval: 46.29 %–100.00 %) and 98.95 % specificity (95 % confidence interval: 93.44 %–99.95 %). In determining Down syndrome alone, specificity (95 % confidence interval: 95.25 %- 100.00 %) and sensitivity (95 % confidence interval: 31.00 %–100.00 %) turned out to be 100 %. In 2015, the average turnaround time for analysis was 8.3 days from the day when the sample was taken. Repeated blood sampling was required in 2 cases (redraw rate = 1.6 %). Conclusions: Our results confirm that NIPT rep- resents a fast, safe and highly accurate advanced screening test for most common chromosomal abnormalities. In current clinical practice, NIPT would significantly decrease the number of unnecessary invasive procedures and the rate of fetal loss caused by invasive diagnostics.
Keywords: non-invasive prenatal DNA testing, chromosomal abnormalities, Down syndrome, pregnancy, fetal DNA
Published: 10.05.2017; Views: 951; Downloads: 288
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