1. Addressing the needs of the rapidly aging society through the development of multifunctional bioactive coatings for orthopedic applicationsTinkara Mastnak, Uroš Maver, Matjaž Finšgar, 2022, pregledni znanstveni članek Opis: The unprecedented aging of the world’s population will boost the need for orthopedic
implants and expose their current limitations to a greater extent due to the medical complexity of
elderly patients and longer indwelling times of the implanted materials. Biocompatible metals with
multifunctional bioactive coatings promise to provide the means for the controlled and tailorable
release of different medications for patient-specific treatment while prolonging the material’s lifespan
and thus improving the surgical outcome. The objective of this work is to provide a review of several
groups of biocompatible materials that might be utilized as constituents for the development of
multifunctional bioactive coatings on metal materials with a focus on antimicrobial, pain-relieving,
and anticoagulant properties. Moreover, the review presents a summary of medications used in
clinical settings, the disadvantages of the commercially available products, and insight into the latest
development strategies. For a more successful translation of such research into clinical practice, extensive knowledge of the chemical interactions between the components and a detailed understanding
of the properties and mechanisms of biological matter are required. Moreover, the cost-efficiency of
the surface treatment should be considered in the development process.
Ključne besede: biomaterials, orthopedic implants, multifunctional coatings, drug delivery, antimicrobial, pain relief
Objavljeno v DKUM: 09.04.2025; Ogledov: 0; Prenosov: 6
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2. Cross-cultural adaptation and validation of the Slovenian version of the Core outcome measures index for low back painMatevž Topolovec, David Vozlič, Nejc Plohl, Rok Vengust, Miha Vodičar, Anne Frances Mannion, 2020, izvirni znanstveni članek Opis: Background:To conduct a cross-cultural adaptation and validation of the Core Outcome Measures Index (COMI) in the Slovenian language, for use in patients with low back pain.
Methods:The English version of COMI was translated into Slovene following established guidelines. Three hundredfifty-three patients with chronic low back pain were recruited from the Orthopedic clinic department of a tertiary care teaching institution. Data quality, construct validity, responsiveness, and test-retest reliability of the COMI were assessed.
Results: The questionnaire was generally well accepted with no missing values. The majority of items exhibited only mild ceiling effects (below 20.0%) and some what more prominent floor effects, which were similar to previousstudies (4.5-78.8%). Correlations with Oswestry Disability Index (ODI) were high (= 0.76 between overall COMI andODI scores), suggesting that the Slovene version of COMI had high construct validity. Additionally, the Slovene version of COMI successfully captured surgical patients' improvement in their low back problem after surgery(overall COMI score change: Z =9.34,p< .001, r =0.53) and showed acceptable test-retest reliability (ICC = 0.86).
Conclusions:The Slovene version of COMI showed good psychometric properties, comparable to those of previously tested language versions. It represents a valuable instrument for the use in future domestic and multicenter clinical studies.
Ključne besede: low back pain, validation, core outcome measures index, cross-cultural adaptation, Slovenia
Objavljeno v DKUM: 27.12.2024; Ogledov: 0; Prenosov: 12
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4. European* clinical practice recommendations on opioids for chronic noncancer pain - Part 1 : role of opioids in the management of chronic noncancer painWinfried Hauser, Bart Morlion, Kevin E. Vowles, Kirsty Bannister, Eric Buchser, Roberto Casale, Jean-François Chenot, Gillian Chumbley, Asbjørn M. Drewes, Gert Dom, Liisa Jutila, Tony O'Brien, Esther Pogatzky-Zahn, Martin Rakuša, Carmen Suarez-Serrano, Thomas Tölle, Nevenka Krčevski-Škvarč, 2021, izvirni znanstveni članek Opis: Background: Opioid use for chronic non-cancer pain (CNCP) is complex. In the absence of pan-European guidance on this issue, a position paper was commissioned by the European Pain Federation (EFIC).
Methods: The clinical practice recommendations were developed by eight scientific societies and one patient self-help organization under the coordination of EFIC. A systematic literature search in MEDLINE (up until January 2020) was performed. Two categories of guidance are given: Evidence-based recommendations (supported by evidence from systematic reviews of randomized controlled trials or of observational studies) and Good Clinical Practice (GCP) statements (supported either by indirect evidence or by case-series, case-control studies and clinical experience). The GRADE system was applied to move from evidence to recommendations. The recommendations and GCP statements were developed by a multiprofessional task force (including nursing, service users, physicians, physiotherapy and psychology) and formal multistep procedures to reach a set of consensus recommendations. The clinical practice recommendations were reviewed by five external reviewers from North America and Europe and were also posted for public comment.
Results: The key clinical practice recommendations suggest: (a) first optimizing established non-pharmacological treatments and non-opioid analgesics and (b) considering opioid treatment if established non-pharmacological treatments or non-opioid analgesics are not effective and/or not tolerated and/or contraindicated. Evidence- and clinical consensus-based potential indications and contraindications for opioid treatment are presented. Eighteen GCP recommendations give guidance regarding clinical evaluation, as well as opioid treatment assessment, monitoring, continuation and discontinuation.
Conclusions: Opioids remain a treatment option for some selected patients with CNCP under careful surveillance.
Significance: In chronic pain, opioids are neither a universal cure nor a universally dangerous weapon. They should only be used for some selected chronic noncancer pain syndromes if established non-pharmacological and pharmacological treatment options have failed in supervised pain patients as part of a comprehensive, multi-modal, multi-disciplinary approach to treatment. In this context alone, opioid therapy can be a useful tool in achieving and maintaining an optimal level of pain control in some patients.
Ključne besede: pain, cronic disease, analgesia, opioid analgesics
Objavljeno v DKUM: 16.08.2024; Ogledov: 69; Prenosov: 9
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5. Multilayer methacrylate-based wound dressing as a therapeutic tool for targeted pain reliefTanja Zidarič, Kristijan Skok, Kristjan Orthaber, Matevž Pristovnik, Lidija Gradišnik, Tina Maver, Uroš Maver, 2023, izvirni znanstveni članek Opis: This study presents an innovative wound dressing system that offers a highly effective therapeutic solution for treating painful wounds. By incorporating the widely used non-steroidal anti-inflammatory drug diclofenac, we have created an active wound dressing that can provide targeted pain relief with ease. The drug was embedded within a biocompatible matrix composed of polyhydroxyethyl methacrylate and polyhydroxypropyl methacrylate. The multilayer structure of the dressing, which allows for sustained drug release and an exact application, was achieved through the layer-by-layer coating technique and the inclusion of superparamagnetic iron platinum nanoparticles. The multilayered dressings’ physicochemical, structural, and morphological properties were characterised using various methods. The synergistic effect of the incorporated drug molecules and superparamagnetic nanoparticles on the surface roughness and release kinetics resulted in controlled drug release. In addition, the proposed multilayer wound dressings were found to be biocompatible with human skin fibroblasts. Our findings suggest that the developed wound dressing system can contribute to tailored therapeutic strategies for local pain relief.
Ključne besede: wound dressings, pain relief, superparamagnetic nanoparticles, methacrylate
Objavljeno v DKUM: 19.04.2024; Ogledov: 485; Prenosov: 473
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6. Contemporary approach to diagnostics in women with suspected pelvic endometriosisJure Knez, Andraž Dovnik, Maja Pakiž, Igor But, Milan Reljič, Vida Gavrić-Lovrec, Maja Banović, Iztok Takač, 2019, pregledni znanstveni članek Ključne besede: endometriosis, endometrioma, ovarian cysts, deep pelvic endometriosis, ultrasound, pelvic pain
Objavljeno v DKUM: 27.03.2024; Ogledov: 258; Prenosov: 16
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7. Neuropilin (NRPs) related pathological conditions and their modulatorsMatic Broz, Anja Kolarič, Marko Jukič, Urban Bren, 2022, pregledni znanstveni članek Opis: Neuropilin 1 (NRP1) represents one of the two homologous neuropilins (NRP, splice variants of neuropilin 2 are the other) found in all vertebrates. It forms a transmembrane glycoprotein distributed in many human body tissues as a (co)receptor for a variety of different ligands. In addition to its physiological role, it is also associated with various pathological conditions. Recently, NRP1 has been discovered as a coreceptor for the SARS-CoV-2 viral entry, along with ACE2, and has thus become one of the COVID-19 research foci. However, in addition to COVID-19, the current review also summarises its other pathological roles and its involvement in clinical diseases like cancer and neuropathic pain. We also discuss the diversity of native NRP ligands and perform a joint analysis. Last but not least, we review the therapeutic roles of NRP1 and introduce a series of NRP1 modulators, which are typical peptidomimetics or other small molecule antagonists, to provide the medicinal chemistry community with a state-of-the-art overview of neuropilin modulator design and NRP1 druggability assessment.
Ključne besede: neuropilins, computer-aided drug design, in silico drug design, receptor modulator design, peptidomimetics, small-molecule antagonists, cancer, COVID-19, neuropathic pain
Objavljeno v DKUM: 22.08.2023; Ogledov: 379; Prenosov: 375
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8. Common and specific large-scale brain changes in major depressive disorder, anxiety disorders, and chronic pain : a transdiagnostic multimodal meta-analysis of structural and functional MRI studiesFelix Brandl, Benedikt Weise, Satja Mulej Bratec, Nazia Jassim, Daniel Hoffmann Ayala, Teresa Bertram, Markus Ploner, Christian Sorg, 2022, izvirni znanstveni članek Opis: Major depressive disorder (MDD), anxiety disorders (ANX), and chronic pain (CP) are closely-related disorders with both high degrees of comorbidity among them and shared risk factors. Considering this multi-level overlap, but also the distinct phenotypes of the disorders, we hypothesized both common and disorder-specific changes of large-scale brain systems, which mediate neural mechanisms and impaired behavioral traits, in MDD, ANX, and CP. To identify such common and disorder-specific brain changes, we conducted a transdiagnostic, multimodal meta-analysis of structural and functional MRI-studies investigating changes of gray matter volume (GMV) and intrinsic functional connectivity (iFC) of large-scale intrinsic brain networks across MDD, ANX, and CP. The study was preregistered at PROSPERO (CRD42019119709). 320 studies comprising 10,931 patients and 11,135 healthy controls were included. Across disorders, common changes focused on GMV-decrease in insular and medial-prefrontal cortices, located mainly within the so-called default-mode and salience networks. Disorder-specific changes comprised hyperconnectivity between defaultmode and frontoparietal networks and hypoconnectivity between limbic and salience networks in MDD; limbic network hyperconnectivity and GMV-decrease in insular and medial-temporal cortices in ANX; and hypoconnectivity between salience and default-mode networks and GMV-increase in medial temporal lobes in CP. Common changes suggested a neural correlate for comorbidity and possibly shared neuro-behavioral chronification mechanisms. Disorder-specific changes might underlie distinct phenotypes and possibly additional disorder-specific mechanisms.
Ključne besede: human threat behaviour, major depressive disorder, anxiety disorders, chronic pain, structural MRI, functional MRI
Objavljeno v DKUM: 18.08.2023; Ogledov: 422; Prenosov: 57
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9. Psychosocial factors in the development of low back pain among professional driversFriderika Kresal, Tine Bertoncel, Maja Meško, 2017, izvirni znanstveni članek Opis: Background and purpose: Professional drivers as a group are exposed to high risk of developing low back pain due to ergonomic factors and work conditions. The purpose of the study was to examine to what extent the low back pain occurs among Slovene professional drivers as a result of the development of various psychosocial factors.
Methodology: The study involved 275 respondents (professional bus drivers, car/van drivers, international truck/ lorry drivers, and ambulance car drivers). Hypotheses were tested using multivariate statistical method (regression analysis) and analysis of variance. Data were collected by structured questionnaire comprised of three parts: socio-demographic data, basic psychosocial factors causing low back pain, and incidence, duration and severity of low back pain as a result of psychosocial risk factors, was implemented.
Results: The results of quantitative survey suggest that low back pain is mostly caused by lifting and carrying heavy loads, inadequate working conditions, poor physical fitness, regular nights out, shift work, and stress. Only the impact of gender on low back pain distress among professional drivers was confirmed, predominantly among bus drivers and lorry drivers on international routes. Low back pain occurrence was less common, albeit not statistically significant, among professional drivers of vans and passenger cars.
Conclusion: Our study suggests that psychosocial factors are also important cause for the development of low back pain among professional drivers and can limit the quality of their social and professional lives.
Ključne besede: low back pain, psychosocial factors, professional drivers, prevention, Slovenia
Objavljeno v DKUM: 18.01.2018; Ogledov: 1427; Prenosov: 364
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10. The correlation between pain perception among patients with six different orthodontic archwires and the degree of dental crowdingEvgenija Marković, Janko Ferčec, Ivana Ščepan, Branislav Glišić, Nenad Nedeljković, Jovana Juloski, Rebeka Rudolf, 2015, izvirni znanstveni članek Opis: Introduction: Forces generated in orthodontic treatment with fixed appliances create tension and compression zones in the periodontal ligament resulting in a painful experience for patients. In the first phase of orthodontic treatment, when leveling of teeth is needed, nickel-titanium (NiTi) archwires can be completely engaged in brackets, even in the cases of extreme crowding, exerting small forces. There is a great individual variation in the pain perception related to the application of orthodontic forces.
Objective: The aim of this study was to investigate the pain perception among patients with dental crowding after insertion of six different NiTi orthodontic archwires as a part of fixed appliances in the first stage of orthodontic treatment.
Methods: The study was conducted on a sample of 189 orthodontic patients receiving one of six different either superelastic or heat activated NiTi archwires, in the first phase of orthodontic treatment. Pain perception was evaluated in groups of patients with different degree of crowding. The modified McGill Pain Questionnaire with Visual Analogue Scale was used to evaluate the quality and intensity of pain. Statistical analysis was performed using simple descriptive statistics, and Pearson`s chi-square test with statistical significance of p<0.05.
Results: Majority of patients reported pain as discomfort or pressure of moderate intensity caused by chewing or biting, started within 12 hours, carried on for 3-4 days, and decreased over time without self-medication.
Conclusion: No correlation was found between pain perception among patients with different types of NiTi archwires and the degree of crowding.
Ključne besede: nickel-titanium archwires, pain, dental crowding, orthodontics
Objavljeno v DKUM: 04.08.2017; Ogledov: 1293; Prenosov: 358
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