1. Novel methacrylate-based multilayer nanofilms with incorporated FePt-based nanoparticles and the anticancer drug 5-fluorouracil for skin cancer treatmentKristijan Skok, Tanja Zidarič, Kristjan Orthaber, Matevž Pristovnik, Nina Kostevšek, Kristina Žužek Rožman, Sašo Šturm, Lidija Gradišnik, Uroš Maver, Tina Maver, 2022, original scientific article Abstract: Despite medical advances, skin-associated disorders continue to pose a unique challenge to physicians worldwide. Skin cancer is one of the most common forms of cancer, with more than one million new cases reported each year. Currently, surgical excision is its primary treatment; however, this can be impractical or even contradictory in certain situations. An interesting potential alternative could lie in topical treatment solutions. The goal of our study was to develop novel multilayer nanofilms consisting of a combination of polyhydroxyethyl methacrylate (PHEMA), polyhydroxypropyl methacrylate (PHPMA), sodium deoxycholate (NaDOC) with incorporated superparamagnetic iron–platinum nanoparticles (FePt NPs), and the potent anticancer drug (5-fluorouracil), for theranostic skin cancer treatment. All multilayer systems were prepared by spin-coating and characterised by atomic force microscopy, infrared spectroscopy, and contact angle measurement. The magnetic properties of the incorporated FePt NPs were evaluated using magnetisation measurement, while their size was determined using transmission electron microscopy (TEM). Drug release performance was tested in vitro, and formulation safety was evaluated on human-skin-derived fibroblasts. Finally, the efficacy for skin cancer treatment was tested on our own basal-cell carcinoma cell line.
Keywords: nanomaterials, bimodal therapy, topical skin treatmen, magnetic nanoparticles, thin films, skin cancer, methacrylates
Published in DKUM: 04.07.2024; Views: 98; Downloads: 16
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3. Nanomaterials and their recent applications in impedimetric biosensingZala Štukovnik, Regina Fuchs-Godec, Urban Bren, 2023, review article Abstract: Impedimetric biosensors measure changes in the electrical impedance due to a biochemical process, typically the binding of a biomolecule to a bioreceptor on the sensor surface. Nanomaterials can be employed to modify the biosensor's surface to increase the surface area available for biorecognition events, thereby improving the sensitivity and detection limits of the biosensor. Various nanomaterials, such as carbon nanotubes, carbon nanofibers, quantum dots, metal nanoparticles, and graphene oxide nanoparticles, have been investigated for impedimetric biosensors. These nanomaterials have yielded promising results in improving sensitivity, selectivity, and overall biosensor performance. Hence, they offer a wide range of possibilities for developing advanced biosensing platforms that can be employed in various fields, including healthcare, environmental monitoring, and food safety. This review focuses on the recent developments in nanoparticle-functionalized electrochemical-impedimetric biosensors.
Keywords: impedimetric biosensor, electrochemical impedance spectroscopy, nanomaterials, metal nanoparticles, carbon nanofibers, carbon nanotubes, graphene oxide, quantum dots
Published in DKUM: 12.02.2024; Views: 6175; Downloads: 24
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4. Reconstruction of a fluid bed device for separating granular material from the grinding process of rapid antigen testsMiha Jordan, Tilen Švarc, Peter Majerič, Rebeka Rudolf, Matej Zadravec, 2023, original scientific article Abstract: The article includes the study and reconstruction of a fluid bed device with the purpose of separating the granular material from the grinding process of rapid antigen tests. The following techniques were performed, with the purpose of characterisation of the ground particles: sieve analysis, X-ray fluorescence spectroscopy, scanning electron microscopy, energy dispersive X-ray spectroscopy and transmission electron microscopy. The paper includes experimental testing of a simplified separation process with zeolite spheres and paper strips, supported by a numerical model. The flow conditions’ impact on the behaviour and interactions of particles of the considered problem were simulated using coupled computational fluid dynamics (CFD) and the discrete element method (DEM) approach. The separation process of zeolite spheres and paper strips was found to be efficient. The simulation results showed the appropriate behaviour of the particles during the process. We explained the results’ deviations, and we also presented the shortcomings and possible improvements. Further research is required to define the adequacy of the process, while using actual ground material of rapid antigen tests.
Keywords: rapid antigen tests, nanomaterials, fluidised bed, computational fluid dynamics, discrete element method, characterisation
Published in DKUM: 05.01.2024; Views: 378; Downloads: 41
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